Salt-Inducible Kinase 2 Proteine (SIK2)

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Zusätzlich bieten wir Ihnen SIK2 Antikörper (102) und SIK2 Kits (13) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIK2 23235 Q9H0K1
SIK2 235344 Q8CFH6
Ratte SIK2 SIK2 315649  
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Top SIK2 Proteine auf antikoerper-online.de

Showing 9 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details
Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$736.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$932.80
Details
Insektenzellen Human GST tag 5 μg Anmelden zum Anzeigen 11 bis 12 Tage
$516.00
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$363.67
Details
Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
Details

SIK2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , ,
Mouse (Murine) ,
,

Weitere Proteine zu Salt-Inducible Kinase 2 (SIK2) Interaktionspartnern

Human Salt-Inducible Kinase 2 (SIK2) Interaktionspartner

  1. Data suggest that cAMP/protein kinase A-dependent phosphorylation of SIK1, SIK2, and SIK3 inhibits their catalytic activity by inducing 14-3-3 protein binding.

  2. results of this study indicate that SIK2 expression can serve as a prognostic biomarker for EOC and that miR-874-3p and miR-874-5p have the potential to enhance clinical treatment of EOC

  3. SIK2 controls osteocyte responses to parathyroid hormone.

  4. The results suggest that activation of SIK2 is required for the cell viability when proteasome activity is inhibited by peritoneal dialysis solutions.

  5. Data demonstrate that SIK2 and SIK3 mRNA are downregulated in adipose tissue from obese individuals and that the expression is regulated by weight change. SIK2 is also negatively associated with in vivo insulin resistance (HOMA-IR), independently of BMI and age.

  6. salt-inducible kinase inhibition decreases proinflammatory cytokines in human myeloid cells upon IL-1R stimulation.

  7. Activated SIK2 plays a dual role in augmenting AMPK-induced phosphorylation of acetyl-CoA carboxylase and in activating the PI3K/AKT pathway through p85alpha-S154 phosphorylation. These findings identify SIK2 at the apex of the adipocyte-induced signaling cascades in cancer cells.

  8. Findings suggest that SIK2 restricts autophagic flux which in the claudin-low subtype is essential for viability of triple-negative breast cancer cells.

  9. Data show that microRNA miR-203 and the salt-inducible kinase 2 (SIK2) are reverse expressed in colorectal tumors.

  10. Examination of SIK2 in prostate cancer cells found that it functions both as a positive regulator of cell-cycle progression and a negative regulator of CREB1 activity. Also, the study shows high levels of auto-antibodies against SIK2 in plasma.

  11. this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A and CaMKI and PME-1 networks may function in fine-tuning cell proliferation and stress response.

  12. a mechanism by which the interplay between SIK2 and p97/VCP contributes to the regulation of ERAD in mammalian cells.

  13. These findings revealed a new function of LKB1 and salt-inducible kinases as negative regulators of HTLV-1 transcription.

  14. tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases

  15. findings uncover SIK2 as a critical determinant in autophagy progression and further suggest a mechanism in which the interplay among kinase and deacetylase activities contributes to cellular protein pool homeostasis.

  16. In adipocytes, Ser358 (not Ser587) is the main site phosphorylated and responsible for the binding of SIK2 to 14-3-3 proteins.

  17. Depletion of SIK2 also delayed G1/S transition and reduced AKT phosphorylation. Higher expression of SIK2 significantly correlated with poor survival in patients with high-grade serous ovarian cancers

  18. Increased SIK2 expression is associated with diffuse large B-cell lymphoma.

Mouse (Murine) Salt-Inducible Kinase 2 (SIK2) Interaktionspartner

  1. Mutant Gnas is critical for pancreatic tumour tumorigenesis, driven by protein-kinase-A-mediated suppression of salt-inducible kinases (Sik1-3), and associated with induction of lipid remodelling and fatty acid oxidation.

  2. SIK2 controls osteocyte responses to parathyroid hormone.

  3. SIK-2 participates in inflammation induction after ICH. SIK-2 inhibition via Bosutinib or small interfering RNA decreased inflammation, attenuating brain injury. SIK-2 effects are, at least partly, mediated by CRTC3-cyclic amp-response element binding protein-NF-kappaB signaling pathway.

  4. Data, including data from studies conducted with knockout mice, suggest that Pin1 (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; Pin1 appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin; Pin1 interacts with Sik2 (salt-inducible kinase 2) to regulate calcium signaling.

  5. The data highlight an integral role for SIK2 and SIK3 in innate immunity by preventing the differentiation of macrophages into a potent and stable anti-inflammatory phenotype.

  6. SIK2 acts directly on CRTC2, CRTC3 and HDAC4, and the cAMP-PKA pathway reduces the interaction of SIK2 with CREB-regulated transcription co-activators and PP2A. Downstream, SIK2 increases GLUT4 levels and glucose uptake in adipocytes.

  7. Sik1, Sik2, and Sik3 play a key role as gluconeogenesis suppressors downstream of LKB1 in the liver.

  8. study identifies the salt-inducible kinases as major targets of bosutinib and dasatinib that mediate the effects of these drugs on the innate immune system and provides novel mechanistic insights into the anti-inflammatory properties of these drugs.

  9. Data suggest that SIK2 is critical in regulating whole-body glucose metabolism primarily by controlling the CRTC2-CREB function of the white adipocytes.

  10. The SIK2-p35-PJA2 complex is essential for glucose homeostasis and provides a link between p35-CDK5 and the AMPK family in excitable cells.

  11. tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases

  12. These findings suggest that SIK2 plays critical roles in neuronal survival, is modulated by CaMK I/IV, and regulates CREB via TORC1.

  13. SIK2 represses eumelanogenesis in mice.

  14. low SIK2 activity was associated with increased p300 HAT activity, ChREBP hyperacetylation, and hepatic steatosis

  15. Results support a role for SIK2 in adipocyte energy metabolism. SIK2 may function similarly to AMPK for turning off lipogenesis in low-energy state.

  16. SIK2-TORC2 cascade may be important for the regulation of PGC-1alpha and UCP-1 gene expression in insulin signaling in brown adipose tissue

SIK2 Protein Überblick

Protein Überblick

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Genbezeichner und Symbole assoziert mit Salt-Inducible Kinase 2 Proteine (SIK2)

  • salt inducible kinase 2 (SIK2)
  • salt-inducible kinase 2 (SLK2)
  • salt inducible kinase 2 (Sik2)
  • salt-inducible kinase 2 (Sik2)
  • salt-inducible kinase 2a (sik2a)
  • G630080D20Rik Protein
  • LOH11CR1I Protein
  • QIK Protein
  • RGD1559698 Protein
  • si:dkey-27p23.1 Protein
  • Snf1lk2 Protein
  • snf1lk2a Protein

Bezeichner auf Proteinebene für Salt-Inducible Kinase 2 Proteine (SIK2)

SIK-2 , SNF1-like kinase 2 , qin-induced kinase , salt-inducible protein kinase 2 , salt-inducible serine/threonine kinase 2 , serine/threonine-protein kinase SIK2 , serine/threonine-protein kinase SNF1-like kinase 2 , salt-inducible kinase 2 , salt induceable kinase 2 , SNF1-like kinase 2a

GENE ID SPEZIES
23235 Homo sapiens
100189673 Pongo abelii
235344 Mus musculus
315649 Rattus norvegicus
768557 Gallus gallus
451540 Pan troglodytes
489410 Canis lupus familiaris
539570 Bos taurus
100718040 Cavia porcellus
100126142 Danio rerio
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