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Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Zusätzlich bieten wir Ihnen SIK2 Antikörper (99) und SIK2 Kits (13) und viele weitere Produktgruppen zu diesem Protein an.
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The results suggest that activation of SIK2 is required for the cell viability when proteasome activity is inhibited by peritoneal dialysis solutions.
Data demonstrate that SIK2 and SIK3 mRNA are downregulated in adipose tissue from obese individuals and that the expression is regulated by weight change. SIK2 is also negatively associated with in vivo insulin (zeige INS Proteine) resistance (HOMA-IR), independently of BMI and age.
Activated SIK2 plays a dual role in augmenting AMPK (zeige PRKAA1 Proteine)-induced phosphorylation of acetyl-CoA carboxylase and in activating the PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) pathway through p85alpha-S154 phosphorylation. These findings identify SIK2 at the apex (zeige APEX1 Proteine) of the adipocyte-induced signaling cascades in cancer cells.
Findings suggest that SIK2 restricts autophagic flux which in the claudin-low subtype is essential for viability of triple-negative breast cancer cells.
Data show that microRNA miR (zeige MLXIP Proteine)-203 and the salt-inducible kinase 2 (SIK2) are reverse expressed in colorectal tumors.
Examination of SIK2 in prostate cancer cells found that it functions both as a positive regulator of cell-cycle (zeige C13orf15 Proteine) progression and a negative regulator of CREB1 (zeige CREB1 Proteine) activity. Also, the study shows high levels of auto-antibodies against SIK2 in plasma.
this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A (zeige PPP2R4 Proteine) and CaMKI (zeige CAMK1 Proteine) and PME-1 (zeige PPME1 Proteine) networks may function in fine-tuning cell proliferation and stress response.
a mechanism by which the interplay between SIK2 and p97/VCP (zeige vcp Proteine) contributes to the regulation of ERAD in mammalian cells.
These findings revealed a new function of LKB1 (zeige STK11 Proteine) and salt-inducible kinases as negative regulators of HTLV-1 transcription.
tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases
SIK-2 participates in inflammation induction after ICH (zeige ACE Proteine). SIK-2 inhibition via Bosutinib or small interfering RNA decreased inflammation, attenuating brain injury. SIK-2 effects are, at least partly, mediated by CRTC3 (zeige CRTC3 Proteine)-cyclic amp-response element binding protein-NF-kappaB (zeige NFKB1 Proteine) signaling pathway.
Data, including data from studies conducted with knockout mice, suggest that Pin1 (zeige PIN1 Proteine) (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; Pin1 (zeige PIN1 Proteine) appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (zeige INS Proteine); Pin1 (zeige PIN1 Proteine) interacts with Sik2 (salt-inducible kinase 2) to regulate calcium signaling.
The data highlight an integral role for SIK2 and SIK3 in innate immunity by preventing the differentiation of macrophages into a potent and stable anti-inflammatory phenotype.
SIK2 acts directly on CRTC2 (zeige CRTC2 Proteine), CRTC3 (zeige CRTC3 Proteine) and HDAC4 (zeige HDAC5 Proteine), and the cAMP-PKA pathway reduces the interaction of SIK2 with CREB (zeige CREB1 Proteine)-regulated transcription co-activators and PP2A (zeige PPP2R2B Proteine). Downstream, SIK2 increases GLUT4 (zeige SLC2A4 Proteine) levels and glucose uptake in adipocytes.
Sik1, Sik2, and Sik3 play a key role as gluconeogenesis suppressors downstream of LKB1 (zeige STK11 Proteine) in the liver.
Data suggest that SIK2 is critical in regulating whole-body glucose metabolism primarily by controlling the CRTC2 (zeige CRTC2 Proteine)-CREB (zeige CREB1 Proteine) function of the white adipocytes.
The SIK2-p35 (zeige CDK5R1 Proteine)-PJA2 (zeige PJA2 Proteine) complex is essential for glucose homeostasis and provides a link between p35 (zeige CDK5R1 Proteine)-CDK5 (zeige CDK5 Proteine) and the AMPK (zeige PRKAA1 Proteine) family in excitable cells.
These findings suggest that SIK2 plays critical roles in neuronal survival, is modulated by CaMK (zeige CAMK2G Proteine) I/IV, and regulates CREB (zeige CREB1 Proteine) via TORC1 (zeige CRTC1 Proteine).
SIK2 represses eumelanogenesis in mice.
Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
, SNF1-like kinase 2
, qin-induced kinase
, salt-inducible protein kinase 2
, salt-inducible serine/threonine kinase 2
, serine/threonine-protein kinase SIK2
, serine/threonine-protein kinase SNF1-like kinase 2
, salt-inducible kinase 2
, salt induceable kinase 2