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This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate.
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SOX1 overlapping transcript was found to be highly expressed in differentiated neural stem cells across different time points of differentiation, and its expression correlated with SOX1 gene expression.
The sensitivity was found to be 62% and 83% for DAPK1 (zeige DAPK1 Proteine) and SOX1, respectively, when analyzed separately in the singleplex assay, but increased to 90% in the multiplex assay when either or both of the SOX1 and the DAPK1 (zeige DAPK1 Proteine) gene promoters showed methylation.
Taken together, these data suggest that SOX1 can function as a tumor suppressor partly by interfering with Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling in breast cancer.
the under-expression of SOX1 was associated significantly with SALL4 (zeige SALL4 Proteine) overexpression. This study was the first to evaluate SOX1 underexpression and its association with poor prognosis in esophageal squamous cell carcinoma.
The results of the SRY (zeige SRY Proteine) gene amplification of plasma DNA from pregnant women was the same as that of the amniocyte DNA
The a (zeige SOX10 Proteine)nalysis identified a signaling axis between FGF signaling and the transcription factor Sox1, which is preferentially expressed in stem- and mesenchymal-like breast cancers.
downregulation of SOX-1 was correlated with poor prognosis and tumor development in hepatocellular carcinoma.
SOX 1 suppressed cell growth and invasion in Tu212 cells by inhibiting Wnt (zeige WNT2 Proteine) pathway, and the anti-tumor effect of SOX 1 could be weakened by SOX 2 (zeige SOX2 Proteine), which may be a potential molecular basis for clinical treatment of laryngeal squamous cell carcinoma .
Our results suggest that SOX1 is epigenetically silenced in the majority of NSCLC and restoration of SOX1 inhibited cell migration by regulating actin cytoskeletal remodeling in NSCLC.
SOX1 decreases the expression of beta-catenin (zeige CTNNB1 Proteine) in a proteasome-independent manner.
Continuous expression of Sox1 and Sox2 (zeige SOX2 Proteine) in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.
These results implicate Xenopus Sox1 in neurogenesis, especially brain and eye development.
These results demonstrate a novel role for SOX2 (zeige SOX2 Proteine) in glial process outgrowth and adhesion, and provide new insights into the essential role Muller glia play in the development of retinal cytoarchitecture.
Sox10 (zeige SOX10 Proteine) overexpression causes mammary cells to undergo a mesenchymal transition.
Sox1, a member of the SoxB1 family of transcription factors, is expressed in a subset of radial astrocytes
Data show that a neural crest cells (NCCs) population that is not derived from Sox1(+) dorsal neuroepithelial cells but are derived from Sox1(-) cells differentiate into a significant population of melanocytes in the skin.
Sox1 regulates the size of the cortical neural progenitor pool via suppression of neurogenic cell divisions.
Genetic fate mapping and loss-of-function analysis show that transcription factor Sox1 is expressed in, and required for, a third type of p2-derived interneuron, which has been named V2c.
Our results show that the Bergmann glia population expresses Sox1 during cerebellar development, and that these cells can be isolated and show stem cell characteristics in vitro, suggesting that they could hold a broader potential than previously thought.
These data integrate functional roles of neural patterning factors, Notch (zeige NOTCH1 Proteine) signalling and SOX1 during gliogenesis.
SOX1 is essential for ventral telencephalic development
newly identified enhancer with Sox (zeige QSOX1 Proteine) elements activates the alphaB-crystallin (zeige CRYAB Proteine) promoter in the lens, although they are separated by the entire HSPB2 (zeige HSPB2 Proteine) gene
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development.
SRY-related HMG-box gene 1
, transcription factor SOX-1
, SRY-box containing protein
, sex determining region Y-box 1
, transcription factor Sox-1