SRY (Sex Determining Region Y)-Box 1 Proteine (SOX1)

Human SRY (Sex Determining Region Y)-Box 1 (SOX1) Interaktionspartner

1. SOX1 overlapping transcript was found to be highly expressed in differentiated neural stem cells across different time points of differentiation, and its expression correlated with SOX1 gene expression.

2. The sensitivity was found to be 62% and 83% for DAPK1 and SOX1, respectively, when analyzed separately in the singleplex assay, but increased to 90% in the multiplex assay when either or both of the SOX1 and the DAPK1 gene promoters showed methylation.

3. Taken together, these data suggest that SOX1 can function as a tumor suppressor partly by interfering with Wnt/beta-catenin signaling in breast cancer.

4. the under-expression of SOX1 was associated significantly with SALL4 overexpression. This study was the first to evaluate SOX1 underexpression and its association with poor prognosis in esophageal squamous cell carcinoma.

5. The results of the SRY gene amplification of plasma DNA from pregnant women was the same as that of the amniocyte DNA

6. The analysis identified a signaling axis between FGF signaling and the transcription factor Sox1, which is preferentially expressed in stem- and mesenchymal-like breast cancers.

7. downregulation of SOX-1 was correlated with poor prognosis and tumor development in hepatocellular carcinoma.

8. SOX 1 suppressed cell growth and invasion in Tu212 cells by inhibiting Wnt pathway, and the anti-tumor effect of SOX 1 could be weakened by SOX 2, which may be a potential molecular basis for clinical treatment of laryngeal squamous cell carcinoma .

9. Our results suggest that SOX1 is epigenetically silenced in the majority of NSCLC and restoration of SOX1 inhibited cell migration by regulating actin cytoskeletal remodeling in NSCLC.

10. SOX1 decreases the expression of beta-catenin in a proteasome-independent manner.

11. PAX1 and SOX1 DNA methylation correlate with a cervical intraepithelial neoplasia diagnosis.

12. we successfully established a three-step inducing protocol to derive Neural stem cells from adipose-derived mesenchymal stem cells with high purity by Sox1 activation

13. The methylation index of SOX1 recovered from scrapings of uterine cervix adenocarcinomas is significantly higher than in normal controls.

14. Taken together, these data suggest that SOX1 can function as a tumor suppressor partly by interfering with Wnt/beta-catenin signaling in cervical cancer.

15. Inactivation of SOX1 gene is associated with cisplatin resistance in human non-small cell lung cancer cell.

16. Concomitant epigenetic silencing of SOX1 and SFRPs through promoter hypermethylation is frequent in hepatocellular carcinoma, and this might contribute to abnormal activation of canonical Wnt signal pathway.

17. The level and timing of SOX1 expression affects neural induction as well as neural lineage.

18. These findings suggest that SOX1 might function as an important tumor suppressor during the development of hepatocellular carcinoma.

19. SOX1 antibodies are a specific marker for SCLC-LEMS but they are also found in SCLC patients without paraneoplastic neurological syndromes

20. Transgenic interneuron diversification in the p2 domain is more complex than previously thought and directly implicates Sox1 in this process.

Mouse (Murine) SRY (Sex Determining Region Y)-Box 1 (SOX1) Interaktionspartner

1. Optimal SOXB1 levels are critical for each pluripotent state and for cell fate decisions during exit from naive pluripotency.

2. These results demonstrate a novel role for SOX2 in glial process outgrowth and adhesion, and provide new insights into the essential role Muller glia play in the development of retinal cytoarchitecture.

3. Sox10 overexpression causes mammary cells to undergo a mesenchymal transition.

4. Sox1, a member of the SoxB1 family of transcription factors, is expressed in a subset of radial astrocytes

5. Data show that a neural crest cells (NCCs) population that is not derived from Sox1(+) dorsal neuroepithelial cells but are derived from Sox1(-) cells differentiate into a significant population of melanocytes in the skin.

6. genes induced in a SoxB1-dependent manner appear to constitute repressive gene regulatory networks that are directly interlinked.

7. Sox1 regulates the size of the cortical neural progenitor pool via suppression of neurogenic cell divisions.

8. Genetic fate mapping and loss-of-function analysis show that transcription factor Sox1 is expressed in, and required for, a third type of p2-derived interneuron, which has been named V2c.

9. Our results show that the Bergmann glia population expresses Sox1 during cerebellar development, and that these cells can be isolated and show stem cell characteristics in vitro, suggesting that they could hold a broader potential than previously thought.

10. These data integrate functional roles of neural patterning factors, Notch signalling and SOX1 during gliogenesis.

11. SOX1 is essential for ventral telencephalic development

12. newly identified enhancer with Sox elements activates the alphaB-crystallin promoter in the lens, although they are separated by the entire HSPB2 gene

13. Ventral striatum precursors and their early neuronal differentiation are unaffected in the absence of SOX1, but the prospective neurons fail to migrate to their appropriate position.

14. Sox1 expression by early embryonic progenitor cells initially helps to maintain the cells in cell cycle, but that continued expression subsequently promotes neuronal lineage commitment

15. expression of shRNA against GPM6A markedly reduced the expression of neuroectodermal-associated genes (OTX1, Lmx1b, En1, Pax2, Pax5, Sox1, Sox2, and Wnt1), and also the number of neural stem cells (NSC) derived from D3mshM6A cells

16. Sox1 enhances neuroectodermal commitment and maintenance but blocks further differentiation. In contrast, Pax6 is involved in the progression of neuroectoderm toward radial glia.

Xenopus laevis SRY (Sex Determining Region Y)-Box 1 (SOX1) Interaktionspartner

1. Continuous expression of Sox1 and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.

2. These results implicate Xenopus Sox1 in neurogenesis, especially brain and eye development.