anti-Rh Family C Glycoprotein (RHCG) Antikörper

Functions as an electroneutral and bidirectional ammonium transporter. Zusätzlich bieten wir Ihnen Rh Family C Glycoprotein Kits (14) und Rh Family C Glycoprotein Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
RHCG 51458 Q9UBD6
RHCG 56315 Q9QXP0
RHCG 293048 Q7TNN9
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Top anti-Rh Family C Glycoprotein Antikörper auf antikoerper-online.de

Showing 10 out of 89 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB Western blot analysis of RHCG expression in NCIH460 (A), human testis (B) whole cell lysates. 200 μL 13 bis 14 Tage
$487.50
Details
Human Ziege Unkonjugiert ELISA, IHC, WB ABIN571241 (1µg/ml) staining of Human Testis lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg 6 bis 7 Tage
$429.84
Details
Human Ziege Unkonjugiert ELISA, IHC   100 μg 6 bis 7 Tage
$429.84
Details
Human Ziege Unkonjugiert ELISA, WB 0.1 mg 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Kidney, antibody was diluted at 1:100. 100 μL Verfügbar
$363.46
Details
Human Ziege Unkonjugiert ELISA, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 bis 14 Tage
$639.83
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of RHCG using 293 whole cell lysates 100 μL 11 bis 12 Tage
$390.77
Details
Maus Ziege Unkonjugiert ELISA, WB   0.1 mg 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p) Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. Formalin-fixed and paraffin embedded mouse kidney labeled with Anti-RHCG Polyclonal Antibody, Unconjugated (ABIN872934) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL 3 bis 7 Tage
$317.90
Details
Human Kaninchen Unkonjugiert WB Western blot analysis in NCI-H460 cell line lysates (35ug/lane). Western blot analysis in mouse heart tissue lysates (35ug/lane). 400 μL 2 bis 3 Tage
$515.63
Details

Am meisten referenzierte anti-Rh Family C Glycoprotein Antikörper

  1. Human Polyclonal RHCG Primary Antibody für ELISA, WB - ABIN4241793 : Liu, Chen, Mo, Hui, Cheng, Mohandas, Huang: Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal RHCG Primary Antibody für IHC (p), ELISA - ABIN565616 : Hiatt, Ivanova, Toran, Tarantal, Matsell: Remodeling of the fetal collecting duct epithelium. in The American journal of pathology 2010 (PubMed)

Weitere Antikörper gegen Rh Family C Glycoprotein Interaktionspartner

Human Rh Family C Glycoprotein (RHCG) Interaktionspartner

  1. RhCG and H+ATPases are located within the same cellular protein complex in the kidney and this interaction is required for maximal urinary acidification by H+-ATPases, a prerequisite for efficient NH3 secretion and urine excretion of NH4+.

  2. RHCG was down-regulated in cervical cancers compared to that in normal cervical tissues, and further decreased in cervical cancer cell lines. Functionally, RHCG overexpression reduced cervical cancer cell proliferation and migration, as evidenced by the decreased transforming growth factor (TGF)-beta1, matrix metalloproteinase (MMP)-2 and MMP-9 expressions in cancer cells.

  3. The results support the notion that RHCG is a novel tumor suppressor gene that plays an important role in the development and progression of ESCC.

  4. The molecular mechanism of NH4(+) recruitment and NH3 transport by RHCG is described.

  5. Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are identified as ammonia transporters. They are expressed in specific cell populations and membrane domains in distal renal epithelial cells, where they facilitate ammonia secretion.

  6. RhAG, RhBG and RhCG-exhibit significant permeability to NH3 and show for the first time that RhBG and RhCG can conduct CO2.

  7. Amt and Rh proteins are not functionally equivalent and that permeation takes place according to two distinct mechanisms.

  8. X-ray crystallographic structure of human RhCG, determined at 2.1 A resolution, reveals the mechanism of ammonia transport.

  9. major finding of this study is that RhCG protein is active as an NH(3) channel and that this function does not require any protein partner

  10. RhBG and RhCG facilitate ammonium movement across the plasma membrane; these results favor the hypothesis that these Rh glycoproteins, together with their homolog RhAG, constitute a family of NH3 channels in mammalian cells.

  11. RhCG expression enhanced the ammonium-induced initial alkalinization (related to NH3 influx)& secondary acidification (related to NH4+ influx). Sub-millimolar NH4+ concentrations induced inward currents in voltage-clamped RhCG-expressing cells.

  12. Review. Mutations at positions F74, V137 and F235 resulted in a severe reduction of NH3 transport.

  13. This study concludes that under normal conditions, RhCG is the major putative ammonia transporter expressed in the human kidney and RhBG is not expressed at detectable levels.

  14. Rhbg and Rhcg may contribute to bronchial epithelial cell ammonia metabolism and suggest that they do not contribute to pulmonary carbon dioxide transport.

Mouse (Murine) Rh Family C Glycoprotein (RHCG) Interaktionspartner

  1. RhCG and H+ATPases are located within the same cellular protein complex in the kidney and this interaction is required for maximal urinary acidification by H+-ATPases, a prerequisite for efficient NH3 secretion and urine excretion of NH4+.

  2. We characterized ammonia and ammonium (NH3/NH4 (+)) transport by the rhesus-associated (Rh) glycoproteins RhAG, Rhbg, and Rhcg expressed in Xenopus oocytes. We used ion-selective microelectrodes and two-electrode voltage clamp to measure changes in intracellular pH, surface pH, and whole cell currents induced by NH3/NH4 (+) and methyl amine/ammonium (MA/MA(+)).

  3. investigated the renal adaptive response of acid excretory pathways to high-protein diets containing normal or low amounts of acid-producing sulfur amino acids (SAA) and examined how this adaption requires the RhCG ammonia transporter

  4. Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are identified as ammonia transporters. They are expressed in specific cell populations and membrane domains in distal renal epithelial cells, where they facilitate ammonia secretion.

  5. Rhcg is critically important in the renal response to metabolic acidosis. in mice with intact Rhcg expression, metabolic acidosis does not induce maximal changes in PEPCK, NHE-3, and GS expression despite the presence of persistent metabolic acidosis.

  6. highly expressed in specific cells in the male reproductive tract

  7. hypokalemia increases collecting duct Rhcg expression, and this likely contributes to the hypokalemia-stimulated increase in urinary ammonia excretion, and its adaptive increases in phosphate-dependent glutaminase expression can compensate for the absence of collecting duct Rhcg.

  8. Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct

  9. Rhcg expression in intercalated cells is necessary for the normal renal response to metabolic acidosis, contributing to both basal and acidosis-stimulated ammonia excretion. Adaptations in Rhbg expression occur in response to acid-loading.

  10. Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney.

  11. RhBG and RhCG are present in a major site of ammonia secretion in the kidney, i.e., the CNT and CD, in agreement with their putative role in ammonium transport.

  12. RhCG immunoreactivity is present in bile duct epithelial cells, where it may contribute to ammonium secretion into bile fluid.

  13. The expression of the ammonia transporter family members Rh B glycoprotein (RhBG) and Rh C glycoprotein (RhCG) in the mouse gastrointestinal tract.

  14. These results strongly suggest that RhBG and RhCG transport ammonia by an electroneutral process that involves NH4(+)/H+ exchange resulting in net NH3 translocation.

  15. RhCG-mediated transport is an electroneutral process that is driven by the NH4+ concentration and the transmembrane H+ gradient, effectively exchanging NH4+ for H+ in a process that results in transport of net NH3.

  16. Review. Animal studies show Rhcg has a role in transmembrane NH3 or NH4+ transport in epithelial cells.

  17. Review. Renal RhCG belongs to the Mep/Amt family of ammonium transporters & promotes bi-directional ammonium transport upon heterologous expression in yeast. Its role in ammonium excretion is being studied in knockout mice.

  18. Review. In kidney, Rhcg immunoreactivity is exclusively apical. Rhcg is present in bile duct epithelia. In the gastrointestinal tract, Rhcg exhibits cell-specific, axially heterogeneous, and polarized expression.

  19. RhCG expression enhanced the ammonium-induced initial alkalinization (related to NH3 influx)& secondary acidification (related to NH4+ influx). Sub-millimolar NH4+ concentrations induced inward currents in voltage-clamped RhCG-expressing cells.

  20. a critical role for Rhcg in ammonium handling and pH homeostasis both in the kidney and the male reproductive tract

Zebrafish Rh Family C Glycoprotein (RHCG) Interaktionspartner

  1. is required to facilitate normal ammonia excretion in the zebrafish larva

Rh Family C Glycoprotein (RHCG) Antigen-Profil

Protein Überblick

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.

Genbezeichner und Symbole assoziert mit RHCG

  • Rh family C glycoprotein (RHCG) Antikörper
  • Rh type C glycoprotein (LOC445729) Antikörper
  • Rhesus blood group-associated C glycoprotein (Rhcg) Antikörper
  • Rh family, C glycoprotein (Rhcg) Antikörper
  • Rh family C glycoprotein S homeolog (rhcg.S) Antikörper
  • Rh family, C glycoprotein b (rhcgb) Antikörper
  • BB065800 Antikörper
  • C15ORF6 Antikörper
  • pdrc2 Antikörper
  • rhcg Antikörper
  • rhcgl2 Antikörper
  • rhgk Antikörper
  • slc42a3 Antikörper
  • zgc:77520 Antikörper

Bezeichner auf Proteinebene für RHCG

Rh type C glycoprotein , Rhesus blood group, C glycoprotein , ammonium transporter Rh type C , rh family type C glycoprotein , rh glycoprotein kidney , rhesus blood group family type C glycoprotein , tumor-related protein DRC2 , rhesus-associated C glycoprotein , Rhesus blood group-associated C glycoprotein , Rhesus type C glycoprotein , rh type C glycoprotein , ammonia transporter RhCG , Rhesus blood group, C glycoprotein b , ammonium transporter Rh type C-like 2 , drRhcg1 , rh family type C glycoprotein-like 2 , rhesus blood group family type C glycoprotein-like 2

GENE ID SPEZIES
51458 Homo sapiens
281456 Bos taurus
415490 Gallus gallus
453638 Pan troglodytes
479040 Canis lupus familiaris
664731 Macaca mulatta
445729 Ciona intestinalis
56315 Mus musculus
293048 Rattus norvegicus
733644 Sus scrofa
100009494 Oryctolagus cuniculus
100528009 Ovis aries
792274 Danio rerio
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