Reticulon 3 Proteine (RTN3)

RTN3 belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. Zusätzlich bieten wir Ihnen Reticulon 3 Antikörper (46) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RTN3 10313 O95197
RTN3 20168 Q9ES97
Ratte RTN3 RTN3 140945 Q6RJR6
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Orang-Utan His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

RTN3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Weitere Proteine zu Reticulon 3 (RTN3) Interaktionspartnern

Human Reticulon 3 (RTN3) Interaktionspartner

  1. Overexpression of RTN3 T39 M in cultured neurons led to impaired axonal transport of BACE1. The variants found in this study are likely genetic modifiers for RTN3-mediated formation of neuritic plaques in Alzheimer's disease (AD).

  2. RTN3 is abundantly enriched in dystrophic neurites that surround amyloid plaques found in the brains of Alzheimer's disease (AD) patients and mouse models. RTN3 deficiency causes elevation of BACE1 protein levels, while RTN1 deficiency shows no obvious effects on BACE1 due to compensation by elevated RTN3 expression. These results suggested that RTN3 has more prominent role in AD pathogenesis.

  3. RTN3 regulates very low density lipoprotein (VLDL) secretion by controlling VLDL transport vesicle-mediated endoplasmic reticulum-to-Golgi transport of nascent VLDL.

  4. Here, the authors identified reticulon 3 (RTN3) as a specific receptor for the degradation of endoplasmic reticulum tubules. None of the other reticulon family members have the ability to induce fragmentation of endoplasmic reticulum tubules during starvation.

  5. RTN3 was critical for EGFR-nonclathrin endocytosis (NCE), promoting the creation of plasma membrane - endoplasmic reticulum contact sites that were required for the formation and/or maturation of NCE invaginations.

  6. This study demonstrated that higher intrahepatic RTN3 levels were independently associated with higher intrahepatic HCV viral loads and genotype 1 in HCV-related hepatocellular carcinoma

  7. These results suggested that RTN3 modulates primordial germ cell migration through interaction with, and regulation of, CXCR4.

  8. RTN 3 interacts with the N-terminal domain of EV71 2C, which is crucial for replication of viral RNA. [Review]

  9. Authors demonstrated that the second transmembrane region of RTN3 competed for, and bound to, the AH2 domain of hepatitis C virus NS4B, thus abolishing NS4B self-interaction and leading to the downregulation of viral replication.

  10. In Alzheimer's disease transgenic mouse models, RTN3 deficiency facilitates amyloid deposition.

  11. This study demonistrated that Reduction of beta-amyloid accumulation by reticulon 3.

  12. successful prevention of imunoreactive dystrophic neurites formation should be initiated before RTN3 aggregation

  13. we hypothesis that RTN3 may participate in the continuous process of circulating monocyte recruitment in atherosclerosis.

  14. we examined reticulon-3 expression in cases of Alzheimer's disease, Parkinson's disease, and diffuse Lewy body disease

  15. Reticulons, the only molecular so far to participate in all three apoptosis signaling pathways, may be a novel player in the progress of atherosclerosis.

  16. common genetic variation in the BACE1-interacting proteins, RTN3 an PPIL2, does not influence platelet b-secretase activity or susceptibility to Alzheimer's disease in this population.

  17. CRELD1 could partly change the localization of RTN3 from the endoplasmic reticulum to the plasma membrane and modulate the apoptotic activity of RTN3 through binding with it.

  18. RTN3 mutants w/o the N-terminal or C-terminal or loop domain bound BACE1 like wild-type & reduced Abeta40/42 secretion. Mutants of the the 1st or 2d potential transmembrane domains bound BACE1 but failed to inhibit Abeta secretion.

  19. The ASYIP protein co-localizes with ASY in the endoplasmic reticulum. Characterization of the ASYIP gene helps to clarify ASY-induced apoptosis or Nogo-involved inhibition of neuronal regeneration in the central nervous system.

  20. RTN3 isoforms may contribute, by as yet unknown mechanisms, to neuronal survival and plasticity

Mouse (Murine) Reticulon 3 (RTN3) Interaktionspartner

  1. RTN3 expression is a mediator of RBM3-induced neuroprotection, controlled by novel mechanisms of escape from translational inhibition on cooling.

  2. altered RTN3 levels can impact the axonal transport of BACE1 and demonstrate that reducing axonal transport of BACE1 in axons is a viable strategy for decreasing BACE1 in axonal terminals and, perhaps, reducing amyloid deposition.

  3. RTN3 negatively regulates autophagy to block the clearance of cytoplasmic PrP aggregates.

  4. results show that reticulon 3 may play a role in the trafficking of the synaptic adhesion-like molecules family of adhesion molecules

  5. cDNA of mouse reticulon 3 (mRTN3) was cloned. The gene was mapped at band B of chromosome 19.

  6. RTN3 isoforms may contribute, by as yet unknown mechanisms, to neuronal survival and plasticity

  7. Since other reports have shown that RTN4-A inhibits neuronal outgrowth and restricts the plasticity of the central nervous system, we speculate that RTN3-A1 might play certain roles in the central nervous system.

  8. Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities.

  9. RTN3 co-immunoprecipitated with endogenous beta-site amyloid precursor protein-cleaving enzyme 1, confirming interactions between these two membrane proteins in the mouse brain

Reticulon 3 (RTN3) Protein Überblick

Protein Überblick

This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.

Genbezeichner und Symbole assoziert mit Reticulon 3 Proteine (RTN3)

  • reticulon 3 (RTN3)
  • reticulon 3 (Rtn3)
  • reticulon 3 (rtn3)
  • reticulon 3 (rnt3)
  • reticulon 3 L homeolog (rtn3.L)
  • reticulon-3 (LOC107131155)
  • reticulon 3 S homeolog (rtn3.S)
  • asyip Protein
  • hap Protein
  • MGC56439 Protein
  • nspl2 Protein
  • nsplii Protein
  • rtn3 Protein
  • rtn3-a Protein
  • rtn3-a1 Protein
  • rtn3-b Protein
  • RTN3w Protein
  • XRTN3 Protein
  • zgc:56439 Protein
  • zgc:77630 Protein

Bezeichner auf Proteinebene für Reticulon 3 Proteine (RTN3)

ASY interacting protein , NSP-like protein 2 , NSP-like protein II , homolog of ASY protein , neuroendocrine-specific protein-like 2 , neuroendocrine-specific protein-like II , reticulon-3 , Nsp-like II , reticulon 3 , reticulon protein 3 , RTN3-A1w , reticulon-3-like , RTN3.1 , localized to ER , reticulon family protein , reticulon-3-A , RTN3.2 , reticulon-3-B

10313 Homo sapiens
20168 Mus musculus
140945 Rattus norvegicus
359721 Bos taurus
394047 Danio rerio
451281 Pan troglodytes
476043 Canis lupus familiaris
549516 Xenopus (Silurana) tropicalis
619183 Macaca mulatta
654271 Takifugu rubripes
100137054 Salmo salar
100170398 Ovis aries
100172388 Pongo abelii
100405288 Callithrix jacchus
100476123 Ailuropoda melanoleuca
100512087 Sus scrofa
100593953 Nomascus leucogenys
444146 Xenopus laevis
107131155 Bos taurus
447369 Xenopus laevis
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