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Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. Zusätzlich bieten wir Ihnen REG4 Antikörper (66) und REG4 Kits (57) und viele weitere Produktgruppen zu diesem Protein an.
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Reg4 inhibited apoptosis through regulating MAPK/Erk (zeige MAPK1 Proteine)/Bim (zeige BCL2L11 Proteine) signaling pathway and thereby enhanced the resistance of gastric cancer to 5-Fluorouracil.
Data indicate that REG4 tissue expression is a prognostic marker in subgroups of pancreatic ductal adenocarcinoma patients, and Serum REG4 level might be useful in differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis.
REG4 promotes peritoneal metastasis of gastric cancer through GPR37 (zeige GPR37 Proteine) and triggers a positive feedback loop.
Study demonstrated that REG4, which is overexpressed in pancreatic ductal adenocarcinoma and secreted by cancer cells, promoted macrophage polarization to M2, through at least in part, activation of ERK1/2 and CREB (zeige CREB1 Proteine).
REG4 is a transcriptional target of GATA6 (zeige GATA6 Proteine) and is essential for colorectal tumorigenesis.
This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for follow-up of patients with mucinous ovarian cancer.
aberrant REG4 expression plays an essential role in early ovarian carcinogenesis and is closely linked to mucinous ovarian tumors, differentiation and adverse prognosis of ovarian cancer by modulating proliferation, apoptosis, migration and invasion.
REG4 expression associated with favorable clinicopathological parameters and with higher overall survival from non-mucinous
The Reg IV may be involved in the finetuning of functions exerted by the neuroendocrine cells in the GI-tract.
Colorectal tumor patients with Reg4- and MMP-7 (zeige MMP7 Proteine)-positive tumors had extremely poor overall survival.
sorted Reg4(+) DCS cells promote organoid formation of single Lgr5 (zeige LGR5 Proteine)(+) colon stem cells. DCS cells can be massively produced from Lgr5 (zeige LGR5 Proteine)(+) colon stem cells in vitro by combined Notch (zeige NOTCH1 Proteine) inhibition and Wnt (zeige WNT2 Proteine) activation
data suggest that Reg4 may protect against acinar cell necrosis in experimental pancreatitis by enhancing the expression of Bcl-2 (zeige BCL2 Proteine) and Bcl-xL (zeige BCL2L1 Proteine) via activation of the EGFR (zeige EGFR Proteine)/Akt (zeige AKT1 Proteine) signalling pathway.
Reg IV as an important modulator of gastrointestinal cell susceptibility to irradiation; hence, it is a potential target for adjunctive treatments for human colorectal cancer and other gastrointestinal malignancies.
reg4 is amplified in the early stages of pancreatic cancer development
Cloning and characterization of human REG4/RELP, in addition to cloning of mouse Reg4.
Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity).
, regenerating islet-derived protein 4
, REG-like protein
, gastrointestinal secretory protein
, reg IV
, regenerating gene type IV
, regenerating islet-derived protein IV