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Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Zusätzlich bieten wir Ihnen RIN1 Antikörper (47) und viele weitere Produktgruppen zu diesem Protein an.
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Findings suggest that RIN1 plays an important oncogenic role in clear cell renal cell carcinoma (zeige MOK Proteine) malignancy by activation of EGFR (zeige EGFR Proteine) signaling through interacting with Rab25 (zeige RAB25 Proteine).
Smad2 (zeige SMAD2 Proteine) is a key scaffold, allowing RIN1 to act as a GTP (zeige AK3 Proteine) exchange factor for MFN2 (zeige MFN2 Proteine)-GTPase (zeige RACGAP1 Proteine) activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.
Overexpression experiments in tandem with pull-down assays indicated that specific Ser291/292 phosphorylation of RIN1 favored binding to activated Ras
analysis of a novel deregulated mechanism in chronic myeloid leukemia (zeige BCL11A Proteine) patients, indicating BIN1 (zeige BIN1 Proteine) and RIN1 as players in the maintenance of the abnormal RTK signaling in this hematological disease
Findings suggest that RIN1 orchestrates RAB5 (zeige RAB5A Proteine) activation, ABL kinase activation and BIN1 (zeige BIN1 Proteine) recruitment to determine EGFR (zeige EGFR Proteine) fate.
over-expression of RIN1 may play an important role in the progression of non-small cell lung cancer and RIN1 expression may offer a valuable marker for predicting the outcome of patients with NSCLC
RIN1 plays an important role in gastric adenocarcinoma progression and that a high RIN1 expression predicts an unfavorable prognosis in gastric adenocarcinoma patients.
RIN1 expression could be a potential prognostic predictor for the melanoma patients and provide a potential target therapy for melanoma treatment.
RIN1 expression could be a potential prognostic predictor for bladder urothelial carcinoma (UC) patients.
These data identify a novel PKD signaling pathway through RIN1 and Abl kinases that is involved in the regulation of actin remodeling and cell migration.
BCR (zeige BCR Proteine)-ABL1 (zeige ABL1 Proteine) kinase activity is regulated by RIN1
These results provide insight into regulated expression of Rin1, define a promoter useful in telencephalic neuron studies, and describe a novel REST site variant directing expression to mature neurons.
This study provided evidence that Rin1 normally functions as a negative regulator of fear learning and memory (Rin1-/- mice have enhanced fear conditioning and diminished fear extinction).
Rin1 links histone ubiquitylation to gene silencing and X inactivation.
RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
the EphA4 (zeige EPHA4 Proteine) receptor is required for synaptic plasticity in the amygdala, raising the possibility that an underlying mechanism of Rin1 function in amygdala is to down-regulate EphA4 (zeige EPHA4 Proteine) signaling by promoting its endocytosis.
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Ras and Rab interactor 1
, ras and Rab interactor 1-like
, ras and Rab interactor 1
, ras inhibitor 1
, ras inhibitor JC99
, ras inhibitor RIN1
, ras interaction/interference protein 1
, ras inhibitor