REC8 Homolog (Yeast) Proteine (REC8)

REC8 encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. Zusätzlich bieten wir Ihnen REC8 Antikörper (88) und REC8 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
REC8 56739 Q8C5S7
REC8 9985 O95072
Ratte REC8 REC8 290227 Q6AYJ4
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$814.00
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$230.67
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REC8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
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Weitere Proteine zu REC8 Homolog (Yeast) (REC8) Interaktionspartnern

Cow (Bovine) REC8 Homolog (Yeast) (REC8) Interaktionspartner

  1. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.

Mouse (Murine) REC8 Homolog (Yeast) (REC8) Interaktionspartner

  1. Our genetic analysis demonstrates that cohesins containing STAG3 and REC8 are the main complex required for centromeric cohesion, and RAD21L cohesins are required for normal clustering of pericentromeric heterochromatin. Furthermore, the STAG3/REC8 and STAG3/RAD21L cohesins are the primary cohesins required for axis formation.

  2. REC8-containing cohesin complexes provide canonical SCC, not RAD21 or RAD21L, at the prophase stage of meiosis I in spermatocytes.

  3. To decipher the functions of the two meiosis-specific kleisins, REC8 or RAD21L, together with the only meiosis-specific SMC protein SMC1b, we generated Smc1b-/-Rec8-/- and Smc1b-/-Rad21L-/- mouse mutants.

  4. Rec8 establishes cohesion when activated during DNA replication in fetal oocytes using tamoxifen-inducible Cre. In contrast, no new cohesion is detected when Rec8 is activated in arrested oocytes by tamoxifen despite cohesin synthesis.

  5. Plk1 activity is required for meiotic spindle assembly and REC8 cleavage, with pPlk1Ser137 being the action executor, in mouse oocytes during meiotic division.

  6. effects ofAte1ablation are inferred to be caused, at least in part, by the failure to destroy the C-terminal fragment of Rec8 in the absence of N-terminal arginylation.

  7. Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function

  8. STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions.

  9. Findings indicate that cohesin-mediated long-range interactions facilitate discrete gene expression states within preexisting chromosomal compartments.

  10. Data show that nociceptin induces Rec8 phosphorylation, triggering chromosome dynamics, in spermatocytes during meiosis in postnatal testes.

  11. We report here evidence from the mouse that partial loss of gene function for either Smc1b or Rec8 causes perturbations in the formation of the synaptonemal complex (SC) and affects both synapsis and recombination between homologs during meiotic prophase

  12. show that spermatocytes from mice lacking the two meiosis-specific cohesin subunits RAD21L and REC8 were unable to initiate RAD51- but not DMC1-mediated double-strand break repair

  13. Separase is regulated by two independent mechanisms in meiosis I, binding to securin and inhibitory phosphorylation by CDK1; both must be disrupted to have any effect on either chromosome-associated REC8 levels or premature chromosome separation.

  14. Rec8 cleavage triggers chiasmata resolution during meiosis I and sister centromere disjunction during meiosis II

  15. Analyses of mRNA expression patterns of cohesin subunits Rad21 and Rec8 in mice: germ cell-specific expression of rec8 mRNA in both male and female mice.

  16. Rec8 protein, in association with SMC3 and SMC1beta but not SMC1alpha, is involved in meiosis-specific chromosome behavior; homologous chromosome separation is triggered by selective loss of Rec8 from chromosome arms in meiosis I.

  17. a major role for REC8 in mammalian meiosis is to limit synapsis to between homologous chromosomes.

  18. results suggest that the proteolysis of securin is dependent on ubiquitin-proteasome pathway and is necessary for the degradation of Rec8 during meiotic metaphase-to-anaphase transitions in oocytes

  19. Proteolytic activity of separase is therefore essential for Rec8's removal from chromosome arms and for chiasma resolution but not for PBE.

  20. loss of armRec8 (homolog separation) and cytokinesis are suppressed until anaphase I by Securin

Human REC8 Homolog (Yeast) (REC8) Interaktionspartner

  1. we determined that REC8 interacted with EGR1, and inhibited EMT in gastric cancer cells. We thus propose further studies of the pathways associated with REC8 and EGR1 to potentially find novel targets in the treatment for gastric cancer.

  2. Study confirmed that REC8 was downregulated in gastric neoplasm, especially in the EBV-associated subtype, via promoter methylation.

  3. REC8 being a novel major bona fide tumor suppressor gene and a robust epigenetic target of the PI3K pathway. Aberrant inactivation of REC8 through hypermethylation by the PI3K pathway may represent an important mechanism mediating the oncogenic functions of the PI3K pathway

  4. Indicate that polymorphisms of the Rec 8 gene are not a common cause of severe male factor infertility.

  5. Data show that REC8 is constitutively expressed in tumour cells, along with SGOL1 and SGOL2, and that REC8 becomes modified after irradiation.

  6. The mouse ortholog of REC8L1 is required for proper synapsis of homologous chromosomes during meiosis

REC8 Protein Überblick

Protein Überblick

This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.

Genbezeichner und Symbole assoziert mit REC8 Homolog (Yeast) Proteine (REC8)

  • REC8 meiotic recombination protein (REC8)
  • REC8 meiotic recombination protein (Rec8)
  • REC8 homolog (yeast) (REC8)
  • HR21spB Protein
  • mrec Protein
  • REC8L1 Protein
  • Rec8p Protein

Bezeichner auf Proteinebene für REC8 Homolog (Yeast) Proteine (REC8)

REC8 homolog (yeast) , meiotic recombination protein REC8 homolog , REC8-like 1 , cohesin Rec8p , meiotic cohesion Rec8 , REC8 homolog , cohesion rec8p , human homolog of rad21, S. pombe , kleisin-alpha , meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family , meiotic recombination protein REC8-like 1 , recombination and sister chromatid cohesion protein homolog , meiosis specific sister chromatid cohesion protein

GENE ID SPEZIES
100581128 Nomascus leucogenys
490622 Canis lupus familiaris
516291 Bos taurus
56739 Mus musculus
100127457 Sus scrofa
100713854 Cavia porcellus
9985 Homo sapiens
290227 Rattus norvegicus
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