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REC8 encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners.
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We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 (zeige RNF212 Proteine) influence genome-wide recombination rate, while genetic variants in PRDM9 (zeige PRDM9 Proteine) influence genome-wide hotspot usage.
Our genetic analysis demonstrates that cohesins containing STAG3 and REC8 are the main complex required for centromeric cohesion, and RAD21L (zeige RAD21L1 Proteine) cohesins are required for normal clustering of pericentromeric heterochromatin. Furthermore, the STAG3/REC8 and STAG3/RAD21L (zeige RAD21L1 Proteine) cohesins are the primary cohesins required for axis formation.
REC8-containing cohesin complexes provide canonical SCC (zeige CYP11A1 Proteine), not RAD21 (zeige RAD21 Proteine) or RAD21L (zeige RAD21L1 Proteine), at the prophase stage of meiosis I in spermatocytes.
To decipher the functions of the two meiosis-specific kleisins, REC8 or RAD21L (zeige RAD21L1 Proteine), together with the only meiosis-specific SMC protein (zeige SMC1A Proteine) SMC1b (zeige SMC1B Proteine), we generated Smc1b (zeige SMC1B Proteine)-/-Rec8-/- and Smc1b (zeige SMC1B Proteine)-/-Rad21L (zeige RAD21L1 Proteine)-/- mouse mutants.
Rec8 establishes cohesion when activated during DNA replication in fetal oocytes using tamoxifen-inducible Cre. In contrast, no new cohesion is detected when Rec8 is activated in arrested oocytes by tamoxifen despite cohesin synthesis.
Plk1 activity is required for meiotic spindle assembly and REC8 cleavage, with pPlk1Ser137 being the action executor, in mouse oocytes during meiotic division.
effects ofAte1ablation are inferred to be caused, at least in part, by the failure to destroy the C-terminal fragment of Rec8 in the absence of N-terminal arginylation.
Our findings strengthen the importance of RA and Dazl (zeige DAZL Proteine) in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function
STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions.
Findings indicate that cohesin-mediated long-range interactions facilitate discrete gene expression states within preexisting chromosomal compartments.
Data show that nociceptin induces Rec8 phosphorylation, triggering chromosome dynamics, in spermatocytes during meiosis in postnatal testes.
Study confirmed that REC8 was downregulated in gastric neoplasm, especially in the EBV-associated subtype, via promoter methylation.
REC8 being a novel major bona fide tumor suppressor gene and a robust epigenetic target of the PI3K (zeige PIK3CA Proteine) pathway. Aberrant inactivation of REC8 through hypermethylation by the PI3K (zeige PIK3CA Proteine) pathway may represent an important mechanism mediating the oncogenic functions of the PI3K (zeige PIK3CA Proteine) pathway
Indicate that polymorphisms of the Rec 8 gene are not a common cause of severe male factor infertility.
Data show that REC8 is constitutively expressed in tumour cells, along with SGOL1 (zeige SGOL1 Proteine) and SGOL2, and that REC8 becomes modified after irradiation.
The mouse ortholog of REC8L1 is required for proper synapsis of homologous chromosomes during meiosis
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
REC8 homolog (yeast)
, meiotic recombination protein REC8 homolog
, REC8-like 1
, cohesin Rec8p
, meiotic cohesion Rec8
, REC8 homolog
, cohesion rec8p
, human homolog of rad21, S. pombe
, meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family
, meiotic recombination protein REC8-like 1
, recombination and sister chromatid cohesion protein homolog
, meiosis specific sister chromatid cohesion protein