RAD17 Homolog (S. Pombe) (RAD17) ELISA Kits

The protein encoded by RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. Zusätzlich bieten wir Ihnen RAD17 Homolog (S. Pombe) Antikörper (177) und RAD17 Homolog (S. Pombe) Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
RAD17 5884 O75943
RAD17 19356 Q6NXW6
Anti-Ratte RAD17 RAD17 310034  
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top RAD17 Homolog (S. Pombe) ELISA Kits auf antikoerper-online.de

Showing 1 out of 3 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human
  96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
$480.00
Details

Weitere ELISA Kits für RAD17 Homolog (S. Pombe) Interaktionspartner

Arabidopsis thaliana RAD17 Homolog (S. Pombe) (RAD17) Interaktionspartner

  1. a mutant Rad17 pathway is associated with a general deregulation of DNA repair, which seems to be correlated with a deficiency in non-homologous double strand break repair.

Human RAD17 Homolog (S. Pombe) (RAD17) Interaktionspartner

  1. The Rad17 C-terminal tail is a molecular switch that regulates the 9-1-1 interaction and the ATR pathway.

  2. These data indicate that the interaction with the 9-1-1 complex is not required for Rad17 protein to be an efficient substrate for the UV-induced phosphorylation. Our data also raise the possibility that the 9-1-1 complex plays a negative regulatory role in the Rad17 phosphorylation. We also show that the nucleotide-binding activity of Rad17 is required for its nuclear localization.

  3. In a Japanese population, the variant allele of hRAD17 is significantly associated with a decreased risk of Colorectal Cancer among light smokers and rectal cancer patients and with an increased risk of Colorectal Cancer among heavy smokers.

  4. Authors show that BRCA1 and RAD17 genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-function mutant p53 (zeige TP53 ELISA Kits) proteins.

  5. USP20 and Rad17 interact, and that this interaction is enhanced by UV exposure. We show that USP20 regulation of Rad17 is at the protein level in a proteasome-dependent manner. USP20 depletion results in poor activation of Chk1 (zeige CHEK1 ELISA Kits) protein by phosphorylation

  6. These data suggest that v-Src attenuates ATR-Chk1 signaling through the inhibition of Rad17-Rad9 interaction.

  7. Rad17 is phosphorylated by ATM (zeige ATM ELISA Kits) at Thr622 resulting in a direct interaction of Rad17 with NBS1 (zeige NBN ELISA Kits), facilitating recruitment of MRE11 (zeige MRE11A ELISA Kits), RAD50 (zeige RAD50 ELISA Kits) and ATM (zeige ATM ELISA Kits) to the DNA double-strand breaks.

  8. Our data suggest RAD17 as a novel target protein for gemcitabine combination therapy supplementing or complementing inhibition of CHK1 (zeige CHEK1 ELISA Kits).

  9. Knockdown of Rad17 with two independent siRNAs significantly reduced Chk1 (zeige CHEK1 ELISA Kits) phosphorylation and substantial RPA32 (zeige RPA2 ELISA Kits) Ser33 phosphorylation.

  10. Data indicate that regulation of Rad17 turnover is through the Cdh1 (zeige CDH1 ELISA Kits)/anaphase-promoting complex pathway in breast cancer cells.

Mouse (Murine) RAD17 Homolog (S. Pombe) (RAD17) Interaktionspartner

  1. targeted deletion of an N-terminal part of mRad17, the mouse homolog of the Schizosaccharomyces pombe Rad17 checkpoint clamp-loader component, resulted in embryonic lethality during early/mid-gestation

RAD17 Homolog (S. Pombe) (RAD17) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

Genbezeichner und Symbole assoziert mit RAD17

  • RAD17 checkpoint clamp loader component (RAD17) Antikörper
  • RAD17 checkpoint clamp loader component (rad17) Antikörper
  • Rad17p (RAD17) Antikörper
  • RADIATION SENSITIVE 17 (ATRAD17) Antikörper
  • RAD17 checkpoint clamp loader component (Rad17) Antikörper
  • 9430035O09Rik Antikörper
  • CCYC Antikörper
  • HRAD17 Antikörper
  • K2A18.21 Antikörper
  • K2A18_21 Antikörper
  • MmRad24 Antikörper
  • R24L Antikörper
  • RAD17 Antikörper
  • RAD17SP Antikörper
  • RAD24 Antikörper
  • RADIATION SENSITIVE 17 Antikörper
  • zgc:91969 Antikörper

Bezeichner auf Proteinebene für RAD17

RAD17 homolog (S. pombe) , cell cycle checkpoint protein RAD17-like , cell cycle checkpoint protein RAD17 , Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins , Rad17p , RAD17 homolog , Cell cycle checkpoint protein RAD17 , RAD1 homolog , RF-C activator 1 homolog , RF-C/activator 1 homolog , Rad17-like protein , cell cycle checkpoint protein (RAD17)

GENE ID SPEZIES
100081629 Ornithorhynchus anatinus
100339735 Oryctolagus cuniculus
100385537 Callithrix jacchus
100464145 Ailuropoda melanoleuca
436934 Danio rerio
854550 Saccharomyces cerevisiae S288c
100190842 Pongo abelii
836745 Arabidopsis thaliana
5884 Homo sapiens
19356 Mus musculus
478088 Canis lupus familiaris
513600 Bos taurus
310034 Rattus norvegicus
100065769 Equus caballus
Ausgewählte Anbieter für RAD17 Homolog (S. Pombe) (RAD17) ELISA Kits
Haben Sie etwas anderes gesucht?