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RAB34 encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport.
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Loss-of-function mutations in the Rab34 gene lead to defects in the assembly of primary cilia, in the trafficking of proteins to primary cilia and, consequently, to impaired reception of signals from the Hedgehog (zeige SHH Proteine) pathway.
Although Rab34 regulates both lysosomal positioning and lysosome to phagosome fusion, the latter effect is not due to the regulation of the cytoplasmic accessibility of lysosomes to phagosomes by Rab34.
uncover Rab34/Munc13-2 as a critical part of an alternative Rab7 (zeige RAB7A Proteine)-independent phagosome maturation machinery and lysosome-mediated killing of mycobacteria
results have uncovered a novel mechanism for interorganellar trans-regulation of spatial distribution of lysosomes by Golgi-associated Rab34
The present study demonstrated that RAB34 plays an important role in the initiation and progression of hepatocellular carcinoma (HCC (zeige FAM126A Proteine)). Our results suggest a new therapeutic target for the clinical treatment of HCC (zeige FAM126A Proteine).
Rab34 activity is modulated by SopD2 and is required for maturation of the Salmonella containing vacuole.
NARR is ubiquitously expressed and resides in nucleoli where it colocalizes with ribosomal DNA gene clusters.
MMP19 (zeige MMP19 Proteine) were positively correlated with RAB34.
Rab36 (zeige RAB36 Proteine) may regulate the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34.
The data together indicate that RILP (zeige RILP Proteine), as already demonstrated for several other Rab (zeige HRB Proteine) effector proteins, is capable of self-association, thus probably forming a homo-dimer.
Data suggest that diacylglycerol-activated hmunc13 serves as an effector of Rab34, mediating lysosome-Golgi trafficking.
define Rab34 as a novel member of the secretory pathway acting at the Golgi
B coxsackievirus entry depends on occludin (zeige OCLN Proteine) and require the activity of Rab34, Ras, and Rab5 (zeige RAB5A Proteine), GTPases known to regulate macropinocytosis.
This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. This gene overlaps and shares exon structure with the nine-amino acid residue-repeats (NARR) gene, which encodes a functionally distinct nucleolar protein from a different reading frame.
, ras-related homolog
, ras-related protein Rab-34
, ras-related protein Rab-39
, ras-related protein Rah
, RAB34, member of RAS oncogene family
, Ras-related protein RAB34