Pyruvate Dehydrogenase (Lipoamide) alpha 1 Proteine (PDHA1)

PDHA1 encodes a subunit of mitochondrial ATP synthase. Zusätzlich bieten wir Ihnen PDHA1 Antikörper (172) und PDHA1 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PDHA1 5160 P08559
PDHA1 18597 P35486
PDHA1 29554  
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Top PDHA1 Proteine auf antikoerper-online.de

Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$437.80
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Cynomolgus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,986.50
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,986.50
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,986.50
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,986.50
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Hefe Schimpanse His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,986.50
Details

PDHA1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) Interaktionspartnern

Human Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) Interaktionspartner

  1. Case demonstrates fetal akinesia deformation sequence due to a de novo hemizygous c.498C > T splice-site mutation in the pyruvate dehydrogenase-alpha 1 (PDHA1) gene.

  2. Data show that metformin reduces hypoxia-inducible factor 1alpha (HIF-1alpha) gene expression and increases pyruvate dehydrogenase (PDH) expression.

  3. The report PDHA1 as a new component of brainstem-type Lewy bodies in idiopathic PD, DLB and PARK14, the level of PDHA1 protein being significantly decreased in the putamen and substantia nigra of patients with idiopathic Parkinson's disease .

  4. Findings show that serine-threonine-tyrosine kinase 1 (NOK) mediates glycolysis and nuclear pyruvate dehydrogenase complex (PDC) associated histone acetylation.

  5. The association of mitochondrial microphthalmia-associated transcription factor (MITF) with pyruvate dehydrogenase (PDH) emerges as an important regulator of mast cell function. Our findings indicate that PDH could arise as a new target for the manipulation of allergic diseases.

  6. our results show that negative PDHA1 gene expressionis associated with significantly higher cell stemness in prostate cancer cells and reduced protein expression of this gene is associated with shorter clinical outcome in prostate cancers.

  7. oncoprotein HBXIP enhances glucose metabolism reprogramming through suppressing SCO2 and PDHA1 in breast cancer

  8. Lack of PDHE1alpha protein expression is associated with Esophageal Squamous Cell Carcinoma.

  9. MPO and BPI in CD4(+)T-lymphocytes, and PDHA1 and MRPL42 in CD8(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.

  10. Phosphorylation at distinct serine and tyrosine residues inhibits PDHA1 through distinct mechanisms to impact active site accessibility.

  11. High HK2 expression combined with low phosphorylated PDHA1 expression in the invasive front lesions of colorectal tumors is predictive of tumor aggressiveness and survival.

  12. In the presence of PPARbeta/delta, Vpr induced a 3.3-fold increase in PPAR response element-driven transcriptional activity, a 1.9-fold increase in PDK4 protein expression, and a 1.6-fold increase in the phosphorylated pyruvate dehydrogenase subunit E1alpha.

  13. In this study the phenotypes of patients with PDH deficiency have been divided into three groups of mutations.

  14. Expression of the PDHA1 gene was found in all somatic cells, whereas expression of PDHA2 gene was restricted to germ cells. The switch from X-linked to autosomic gene expression occurred in spermatocytes.

  15. Molecular analysis of PDH1A revealed a novel hemizygous c.1045G>A mutation, predicting a p.A349T missense mutation.

  16. Skin fibroblast culture assay revealed PDH deficiency, confirmed by mutation analysis of the E1 alpha subunit.

  17. TNFalpha can inhibit pulmonary artery smooth muscle cells pyruvate dehydrogenase activity and induce a pulmonary arterial hypertension phenotype.

  18. We provide an efficient stepwise strategy for mutation screening in pyruvate dehydrogenase complex genes and expand the growing list of PDHA1 mutations analyzed at the structural level

  19. Data show that overexpression of ErbB2 maintains PDH flux by suppressing PDK4 expression in an Erk-dependent manner.

  20. 4 affected female patients with PDHA1 mutations who had with severe cortical atrophy, dilated ventricles, and an incomplete corpus callosum.

Zebrafish Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) Interaktionspartner

  1. The study provired that pyruvate dehydrogenase-deficient mutant caused the retinal drficits in zebrafish.

PDHA1 Protein Überblick

Protein Überblick

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit PDHA1

  • pyruvate dehydrogenase E1 alpha 1 subunit (PDHA1)
  • pyruvate dehydrogenase E1 alpha 1 (Pdha1)
  • pyruvate dehydrogenase E1 alpha 1 subunit (Pdha1)
  • pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1)
  • pyruvate dehydrogenase E1 alpha 1 subunit (pdha1)
  • pyruvate dehydrogenase (lipoamide) alpha 1 pseudogene (LOC719277)
  • 2-oxo acid dehydrogenase (VNG_RS07485)
  • pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha (RR_RS04695)
  • pyruvate dehydrogenase alpha subunit protein (pdhA1)
  • pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit (pdhA1)
  • precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit (PDHA1)
  • pyruvate dehydrogenase (PDHA1)
  • pyruvate dehydrogenase E1 alpha 1 subunit b (pdha1b)
  • pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog (pdha1.S)
  • pdha Protein
  • Pdha-1 Protein
  • Pdha1 Protein
  • pdha1-a Protein
  • pdha1-b Protein
  • pdhce1a Protein
  • phe1a Protein
  • wu:fp73b04 Protein
  • zgc:92705 Protein

Bezeichner auf Proteinebene für PDHA1

PDHE1-A type I , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , pyruvate dehydrogenase complex, E1-alpha polypeptide 1 , pyruvate dehydrogenase E1alpha subunit , pyruvate dehydrogenase E1 alpha 1 , pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase alpha 1 , pyruvate dehydrogenase (lipoamide) alpha 1 , PdhA1 , pyruvate dehydrogenase alpha subunit , pyruvate dehydrogenase E1 component subunit alpha , pyruvate dehydrogenase alpha subunit protein , pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit , precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase , Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like , fp73b04 , pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog

GENE ID SPEZIES
5160 Homo sapiens
18597 Mus musculus
29554 Rattus norvegicus
407109 Bos taurus
418610 Gallus gallus
465525 Pan troglodytes
480858 Canis lupus familiaris
549826 Xenopus (Silurana) tropicalis
719277 Macaca mulatta
1448416 Halobacterium sp. NRC-1
3129238 Haloarcula marismortui ATCC 43049
3893971 Rhizobium etli CFN 42
6400117 Rhizobium etli CIAT 652
7195506 Phaeodactylum tricornutum CCAP 1055/1
7369176 Agrobacterium radiobacter K84
7450426 Thalassiosira pseudonana CCMP1335
100174745 Pongo abelii
100294678 Sus scrofa
100357349 Oryctolagus cuniculus
100400144 Callithrix jacchus
100471829 Ailuropoda melanoleuca
100587584 Nomascus leucogenys
436672 Danio rerio
100735725 Cavia porcellus
447434 Xenopus laevis
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