Pyruvate Dehydrogenase (Lipoamide) alpha 1 Proteine (PDHA1)

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. Zusätzlich bieten wir Ihnen PDHA1 Antikörper (169) und PDHA1 Kits (20) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PDHA1 5160 P08559
PDHA1 18597 P35486
PDHA1 29554  
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Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$437.80
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,986.50
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,986.50
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,986.50
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Hefe Cynomolgus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,986.50
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Hefe Schimpanse His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,986.50
Details

PDHA1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) Interaktionspartnern

Human Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) Interaktionspartner

  1. ATP5G1 (zeige ATP5G1 Proteine), ATP5G2 (zeige ATP5G2 Proteine), and ATP5G3 (zeige ATP5G3 Proteine) of the ATP synthase are not involved in forming the permeability transition pore.

  2. Case demonstrates fetal akinesia deformation sequence due to a de novo hemizygous c.498C > T splice-site mutation in the pyruvate dehydrogenase-alpha 1 (PDHA1) gene.

  3. Data show that metformin reduces hypoxia-inducible factor 1alpha (HIF-1alpha (zeige HIF1A Proteine)) gene expression and increases pyruvate dehydrogenase (PDH (zeige PDP Proteine)) expression.

  4. The report PDHA1 as a new component of brainstem-type Lewy bodies in idiopathic PD, DLB and PARK14, the level of PDHA1 protein being significantly decreased in the putamen and substantia nigra of patients with idiopathic Parkinson's disease .

  5. Findings show that serine-threonine-tyrosine kinase 1 (NOK (zeige STYK1 Proteine)) mediates glycolysis and nuclear pyruvate dehydrogenase (zeige PDP Proteine) complex (PDC (zeige PNKD Proteine)) associated histone acetylation.

  6. The association of mitochondrial microphthalmia-associated transcription factor (MITF (zeige MITF Proteine)) with pyruvate dehydrogenase (PDH (zeige PDP Proteine)) emerges as an important regulator of mast cell function. Our findings indicate that PDH (zeige PDP Proteine) could arise as a new target for the manipulation of allergic diseases.

  7. our results show that negative PDHA1 gene expressionis associated with significantly higher cell stemness in prostate cancer cells and reduced protein expression of this gene is associated with shorter clinical outcome in prostate cancers.

  8. ATP5G1 (zeige ATP5G1 Proteine) turnover increases upon depletion of ZC3H14 (zeige ZC3H14 Proteine), double knockdown of ZC3H14 (zeige ZC3H14 Proteine) and the nonsense-mediated decay factor, UPF1 (zeige UPF1 Proteine), rescues ATP5G1 (zeige ATP5G1 Proteine) transcript levels. Furthermore, fractionation reveals an increase in the amount of ATP5G1 (zeige ATP5G1 Proteine) pre-mRNA that reaches the cytoplasm when ZC3H14 (zeige ZC3H14 Proteine) is depleted and that ZC3H14 (zeige ZC3H14 Proteine) binds to ATP5G1 (zeige ATP5G1 Proteine) pre-mRNA in the nucleus.

  9. oncoprotein HBXIP (zeige HBXIP Proteine) enhances glucose metabolism reprogramming through suppressing SCO2 (zeige SCO2 Proteine) and PDHA1 in breast cancer

  10. MPO (zeige MPO Proteine) and BPI (zeige BPI Proteine) in CD4 (zeige CD4 Proteine)(+)T-lymphocytes, and PDHA1 and MRPL42 (zeige MRPL42 Proteine) in CD8 (zeige CD8A Proteine)(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.

Mouse (Murine) Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) Interaktionspartner

  1. Cardiac PDH (zeige PDP Proteine) E1alpha deficiency impairs ischemic AMP-activated protein kinase (zeige PRKAA2 Proteine) signaling and sensitizes hearts to the toxicological actions of ischemic stress.

  2. Taken together, our results indicate that the redox sensing and ROS (zeige ROS1 Proteine) forming properties of Pdh (zeige PDP Proteine) and Ogdh (zeige alphaKGDHC Proteine) are linked to S-glutathionylation

  3. Systemic Pyruvate Dehydrogenase (zeige PDP Proteine) Deficiency is associated with Cerebral Developmental Abnormalities.

  4. The association of mitochondrial microphthalmia-associated transcription factor (MITF (zeige MITF Proteine)) with pyruvate dehydrogenase (PDH (zeige PDP Proteine)) emerges as an important regulator of mast cell function. Our findings indicate that PDH (zeige PDP Proteine) could arise as a new target for the manipulation of allergic diseases.

  5. skeletal muscle IL-6 (zeige IL6 Proteine) contributes to the regulation of PDH (zeige PDP Proteine) at rest and during prolonged exercise.

  6. The present findings suggest that IL-6 (zeige IL6 Proteine) contributes to regulating the PDHa activity and hence carbohydrate oxidation, but the metabolic state of the muscle seems to determine the outcome of this regulation

  7. Liver-specific pyruvate dehydrogenase (zeige PDP Proteine) complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin (zeige INS Proteine) sensitivity.

  8. PGC-1alpha regulates PDH (zeige PDP Proteine)-E1alpha protein content in parallel with mitochondrial oxidative proteins, but does not seem to influence PDH (zeige PDP Proteine) regulation in mouse skeletal muscle in response to fasting and in recovery from exercise.

  9. Embryos carrying predominantly the Pdha1(deletion in exon 8, Deltaex8) allele were found to be globally delayed in development by 9.5 days postcoitus, with resorption occurring over the following several days.

Zebrafish Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) Interaktionspartner

  1. The study provired that pyruvate dehydrogenase (zeige PDK2 Proteine)-deficient mutant caused the retinal drficits in zebrafish.

PDHA1 Protein Überblick

Protein Überblick

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.

Genbezeichner und Symbole assoziert mit PDHA1

  • pyruvate dehydrogenase E1 alpha 1 subunit (PDHA1)
  • ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) (ATP5G1)
  • pyruvate dehydrogenase E1 alpha 1 (Pdha1)
  • pyruvate dehydrogenase E1 alpha 1 subunit (Pdha1)
  • pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1)
  • pyruvate dehydrogenase E1 alpha 1 subunit (pdha1)
  • pyruvate dehydrogenase (lipoamide) alpha 1 pseudogene (LOC719277)
  • 2-oxo acid dehydrogenase (VNG_RS07485)
  • pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha (RR_RS04695)
  • pyruvate dehydrogenase alpha subunit protein (pdhA1)
  • pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit (pdhA1)
  • precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit (PDHA1)
  • pyruvate dehydrogenase (PDHA1)
  • pyruvate dehydrogenase E1 alpha 1 subunit b (pdha1b)
  • pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog (pdha1.S)
  • ATP5A Protein
  • ATP5G Protein
  • pdha Protein
  • Pdha-1 Protein
  • Pdha1 Protein
  • pdha1-a Protein
  • pdha1-b Protein
  • pdhce1a Protein
  • phe1a Protein
  • wu:fp73b04 Protein
  • zgc:92705 Protein

Bezeichner auf Proteinebene für PDHA1

PDHE1-A type I , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , pyruvate dehydrogenase complex, E1-alpha polypeptide 1 , ATP synthase lipid-binding protein, mitochondrial , ATP synthase proteolipid P1 , ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) , ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) , ATPase protein 9 , ATPase subunit 9 , ATPase subunit C , mitochondrial ATP synthase, subunit 9 , mitochondrial ATP synthase, subunit C , pyruvate dehydrogenase E1alpha subunit , pyruvate dehydrogenase E1 alpha 1 , pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase alpha 1 , pyruvate dehydrogenase (lipoamide) alpha 1 , PdhA1 , pyruvate dehydrogenase alpha subunit , pyruvate dehydrogenase E1 component subunit alpha , pyruvate dehydrogenase alpha subunit protein , pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit , precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase , Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like , fp73b04 , pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog

GENE ID SPEZIES
5160 Homo sapiens
516 Homo sapiens
18597 Mus musculus
29554 Rattus norvegicus
407109 Bos taurus
418610 Gallus gallus
465525 Pan troglodytes
480858 Canis lupus familiaris
549826 Xenopus (Silurana) tropicalis
719277 Macaca mulatta
1448416 Halobacterium sp. NRC-1
3129238 Haloarcula marismortui ATCC 43049
3893971 Rhizobium etli CFN 42
6400117 Rhizobium etli CIAT 652
7195506 Phaeodactylum tricornutum CCAP 1055/1
7369176 Agrobacterium radiobacter K84
7450426 Thalassiosira pseudonana CCMP1335
100174745 Pongo abelii
100294678 Sus scrofa
100357349 Oryctolagus cuniculus
100400144 Callithrix jacchus
100471829 Ailuropoda melanoleuca
100587584 Nomascus leucogenys
436672 Danio rerio
100735725 Cavia porcellus
447434 Xenopus laevis
Ausgewählte Anbieter für PDHA1 Proteine (PDHA1)
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