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PURA product is a sequence-specific, single-stranded DNA-binding protein. Zusätzlich bieten wir Ihnen PURA Antikörper (43) und viele weitere Produktgruppen zu diesem Protein an.
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Quantitative immunohistochemical assays of the vermal region of the cerebellum and CA1 (zeige CA1 Proteine)-3 regions of the hippocampus revealed reduced numbers of neurons in general, as well as reduced numbers of Pur-alpha+-immunopositive neurons and dendrites in heterozygous Pur-alpha mice, compared to wild-type littermates
This study underlines the importance of Puralpha in the proliferation of neuronal precursor cells during postnatal brain development and suggest a role for Puralpha in the regulation of the expression and cellular distribution of dendritic and axonal proteins.
Data suggest that Puralpha has a role in nucleotide excision repair and the repair of UVC-induced DNA damage.
Overexpression of Purbeta (zeige PURB Proteine), but not Puralpha, significantly downregulated GnRH1 (zeige GNRH1 Proteine) mRNA Levels in transiently transfected GT1 (zeige MYL4 Proteine)-7 cells, suggesting that Purbeta (zeige PURB Proteine) acts as a repressor of GnRH1 (zeige GNRH1 Proteine) gene transcription.
Identification of mrna/protein (mRNA) complexes and their association with rough endoplasmic reticulum equipped with a kinesin motor
Pura is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation.
we also determined a region in Pur alpha which is required for the association with the purine rich element binding protein by using deletion mutants of Pur alpha
Puralpha has been shown to colocalize with cyclin A (zeige CCNA2 Proteine)/Cdk2 (zeige CDK2 Proteine) and to coimmunoprecipitate with cyclin A (zeige CCNA2 Proteine) during S-phase and we show that this interaction is mediated by a specific affinity of Puralpha for Cdk2 (zeige CDK2 Proteine).
analysis of of DNA binding and localized strand separation by Pur alpha and comparison with Pur beta (zeige PURB Proteine)
Pur alpha and Pur beta (zeige PURB Proteine) repress smooth muscle alpha-actin (zeige ACTA2 Proteine) gene transcription by means of DNA strand-selective cis (zeige CISH Proteine)-element binding and cell type-dependent protein-protein interactions
Three genes in our epilepsy cohort (COQ4 (zeige COQ4 Proteine), DNM1 (zeige DNM1 Proteine), and PURA), accounting for 14% (3/21) of all novel genetic etiologies identified in patients with epilepsy, were subsequently confirmed in independent publications.
PURA may be a potential target of miR (zeige MLXIP Proteine)-144 and observed downregulation of PURA may be caused by increased expression of miR (zeige MLXIP Proteine)-144. The other predicted target of miR (zeige MLXIP Proteine)-144 SPRED1 (zeige SPRED1 Proteine), was found to be downregulated in 69 per cent EC tissues as compared to matched distant non-malignant tissues.
The results of this study emphasizes the importance of stress granules in ALS (zeige IGFALS Proteine) pathogenesis and identifies Pur-alpha as a novel regulator of cytoplasmic stress granules dynamics.
These findings provide definitive evidence for the role of PURA in causing a variable syndrome of neurodevelopmental delay, learning disability, neonatal hypotonia, feeding difficulties, abnormal movements and epilepsy in humans
Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome.
Data show that protein PURalpha is specifically involved in the transcriptional activation of the secondary promoter and may exert its function by forming a complex with E2F-1 and RNA polymerase II.
Suggest dynamic interplay between transcriptional activators Pur-alpha/Pur-beta (zeige PURB Proteine) and repressors in regulating SMalphaA (zeige ACTA2 Proteine) gene output during myofibroblast differentiation.
This study showed that Pur-alpha showed inadequate expression in monocytes, and the translation of Pur-alpha mRNA was repressed by cell-expressed microRNA.
The study identifies three functionally distinct PURA promoters and show that these are utilized differentially in human cell types and that they respond differently to cytomegalovirus infection.
The ability of Puralpha to activate the CD11c (zeige ITGAX Proteine) gene promoter increases in differentiating U937 monocytic cells.
repressor of gata2 gene expression in the nervous system
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
purine-rich element binding protein A
, Pur alpha
, purine-rich single-stranded DNA-binding protein alpha
, transcriptional activator protein Pur-alpha