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Protein Z-79 G/A gene polymorphism may be of a protective value against thrombosis in antiphospholipid syndrome (APS). The G79A polymorphism of protein Z was not found to be an independent risk factor of thrombosis in APS.
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Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.
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Low PZ appears to be an underestimated risk factor for perioperative bleeding. Determination of PZ plasma concentrations might be useful in the preoperative workup in patients with a bleeding history, when detailed clotting analyses remain inconclusive.
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PZ/ZPI polymorphisms do not appear to play an active role in the development of prosthesis heart valve thrombosis.
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Report evidence of a non-linear positive association between PZ level and unexplained stroke, with a directionally consistent association for genetic variants related to PZ levels and cryptogenic stroke.
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Data suggest oxidized lipid vesicles with phosphatidylserine/polyunsaturated fatty acids promote inactivation of ZPI-PZ complex or free ZPI; binding of PZ-complexed or free ZPI to oxidized vesicles mediates inactivation of ZPI (an inhibitor of FXa); blocking heparin- (anticoagulant-)binding site on ZPI interferes with binding to lipid or PZ. (ZPI = protein Z-dependent protease inhibitor; PZ = protein Z; FXa = factor Xa)
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SAA, PROZ, and C4BPB may serve as new potential biomarkers for TB
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Protein Z is a plasma protein involving blood coagulation and inflammation. Low protein Z was found to be associated significantly with acute my.ocardial infarction in coronary atherosclerosis disease patients
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Family-based association study revealed that the G allele of Protein Z rs2273971, and haplotypes GA, CG, and CGA of Protein Z and factor VII had a significant effect on cerebral hemorrhage susceptibility.
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Protein Z G79A AG/AA polymorphism may be a risk factor for thrombosis in systemic lupus erythematosus Egyptian patients.
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There was no significant difference in the clinical features of the patients with and without the polymorphism. We therefore conclude that PZ G79A polymorphism is not a risk factor for puerperal CVT in Indian women.
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Results show the energetic basis of the Z-dependent protease inhibitor (ZPI)-protein Z (PZ) interaction and suggest an important role for ZPI Lys-239 in PZ catalytic action.
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The unbalance between PZ and ZPI in plasma samples from patients with Colorectal Cancer or Pancreatic Cancer is not only related to an inflammatory state but could also results from an ectopic synthesis of these proteins by the cancer cells.
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Protein Z EGF2 subdomain constitutes an interactive-site for ZPI protein.
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Protein Z/protein Z-dependent protease inhibitor and Fxa expression in human gastric cancer cells indicate that these proteins may play a role in anticoagulant events at the tumor tissue.
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active mutations of PZ in the serine protease structural domain were found in women with fetal loss
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Data suggest role for complex of PZ with ZPI (PZ-dependent protease inhibitor) in pregnancy maintenance; this is highlighted by progressive elevation in PZ levels in first trimester of gestation which then steadily decline toward delivery. [REVIEW]
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Specific PZSNPs and haplotypes are significantly associated with idiopathic recurrent miscarriage.
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the PZ/ZPI complex may play some modulating role in hemophilia A
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74 patients a protein Z deficiency has been found.
