Protein Z, Vitamin K-Dependent Plasma Glycoprotein Proteine (PROZ)

Mouse (Murine) Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ) Interaktionspartner

1. Letter: protein Z is not a typical acute phase reactant.

2. PZ and ZPI (zeige SERPINA10 Proteine) deficiency would be associated with a modest thrombotic risk with ZPI (zeige SERPINA10 Proteine) deficiency producing a more severe phenotype.

Human Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ) Interaktionspartner

1. PZ/ZPI (zeige SERPINA10 Proteine) polymorphisms do not appear to play an active role in the development of prosthesis heart valve thrombosis.

2. Data suggest oxidized lipid vesicles with phosphatidylserine/polyunsaturated fatty acids promote inactivation of ZPI (zeige SERPINA10 Proteine)-PZ complex or free ZPI (zeige SERPINA10 Proteine); binding of PZ-complexed or free ZPI (zeige SERPINA10 Proteine) to oxidized vesicles mediates inactivation of ZPI (zeige SERPINA10 Proteine) (an inhibitor of FXa (zeige F10 Proteine)); blocking heparin- (anticoagulant-)binding site on ZPI (zeige SERPINA10 Proteine) interferes with binding to lipid or PZ. (ZPI (zeige SERPINA10 Proteine) = protein Z-dependent protease inhibitor (zeige SERPINA10 Proteine); PZ = protein Z; FXa (zeige F10 Proteine) = factor Xa (zeige F10 Proteine))

3. SAA (zeige SAA1 Proteine), PROZ, and C4BPB (zeige C4BPB Proteine) may serve as new potential biomarkers for TB

4. Protein Z is a plasma protein involving blood coagulation and inflammation. Low protein Z was found to be associated significantly with acute my.ocardial infarction in coronary atherosclerosis disease patients

5. Family-based association study revealed that the G allele of Protein Z rs2273971, and haplotypes GA, CG, and CGA (zeige CGA Proteine) of Protein Z and factor VII (zeige TH Proteine) had a significant effect on cerebral hemorrhage susceptibility.

6. Protein Z G79A AG/AA polymorphism may be a risk factor for thrombosis in systemic lupus erythematosus Egyptian patients.

7. Results show the energetic basis of the Z-dependent protease inhibitor (ZPI (zeige SERPINA10 Proteine))-protein Z (PZ) interaction and suggest an important role for ZPI (zeige SERPINA10 Proteine) Lys (zeige LYZ Proteine)-239 in PZ catalytic action.

8. The unbalance between PZ and ZPI (zeige SERPINA10 Proteine) in plasma samples from patients with Colorectal Cancer or Pancreatic Cancer is not only related to an inflammatory state but could also results from an ectopic synthesis of these proteins by the cancer cells.

9. Protein Z EGF2 subdomain constitutes an interactive-site for ZPI (zeige SERPINA10 Proteine) protein.

10. Protein Z/protein Z-dependent protease inhibitor (zeige SERPINA10 Proteine) and Fxa (zeige F10 Proteine) expression in human gastric cancer cells indicate that these proteins may play a role in anticoagulant events at the tumor tissue.