Protein S (Alpha) Proteine (PROS1)

PROS1 encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. Zusätzlich bieten wir Ihnen PROS1 Antikörper (103) und PROS1 Kits (24) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PROS1 5627 P07225
PROS1 19128 Q08761
PROS1 81750  
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen

Top PROS1 Proteine auf

Showing 9 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 2 bis 3 Tage
Hefe Ratte His tag Protein S (Alpha) (PROS1) (AA 42-675) protein (His tag) expressed in mammalien cells 1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Human Cells Human His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human His-SUMO Tag   100 μg Anmelden zum Anzeigen 11 Days
Escherichia coli (E. coli) Ratte GST tag   100 μg Anmelden zum Anzeigen 11 Days
Mammalian Cells Ratte His tag   100 μg Anmelden zum Anzeigen 2 bis 3 Tage

PROS1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus) , ,

Am meisten referenzierte PROS1 Proteine

  1. Human PROS1 Protein expressed in HEK-293 Cells - ABIN2729817 : Kariolis, Miao, Jones, Kapur, Mathews, Giaccia, Cochran: An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. in Nature chemical biology 2014 (PubMed)

Weitere Proteine zu Protein S (Alpha) (PROS1) Interaktionspartnern

Human Protein S (Alpha) (PROS1) Interaktionspartner

  1. The present case combined with the review of the literature suggests that p.Arg451* in the PROS1 gene mainly leads to clinically evident thrombosis following trauma, surgery or serious comorbidities especially malignancy.

  2. Protein S and Gas6 (zeige GAS6 Proteine) mediates phagocytosis of HIV-1-infected cells by bridging receptor tyrosine kinase (zeige RET Proteine) Mer (zeige MERTK Proteine) to phosphatidylserine exposed on infected cells.

  3. these results suggest a novel pathogenic role of SPE B that initiates protein S degradation followed by the inhibition of apoptotic cell clearance by macrophages

  4. Developed functional protein S assays that measure both the activated protein C (zeige PROC Proteine)- and TFPI (zeige TFPI Proteine)-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.

  5. Taken together, our gain-of-function, loss-of-function analyses suggest that PROS may facilitate cell proliferation and promote castration resistance in human castration-resistant PCa (zeige FLVCR1 Proteine)-like cells via its apoptosis-regulating property.

  6. we identify PROS1 as a driver of Oral Squamous Cell Carcinoma tumor growth and a modulator of AXL (zeige AXL Proteine) expression

  7. The prevalence of PS de fi ciency in the present study was higher than in Western countries and con (zeige DISP1 Proteine) fi rms the high prevalence of PS de fi ciency in Asian populations

  8. Patients with type 2 diabetes had significantly lower circulating free protein S than healthy control subjects

  9. In the present study, gene analysis of six unrelated Japanese families diagnosed with congenital protein S deficiency identified five missense mutations in the PROS1 gene - c.757C>T (Ala139Val; A139V), c.1346 G>T (Cys449Phe; C449F), c.1352G>A (Arg451Gln; R451Q), c.1424G>T (Cys475Phe; C475F) and c.1574C>T (Ala525Val; A525V) - and one frameshift mutation, c.2135delA (Asp599ThrfsTer13; D599TfsTer13).

  10. The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for PROS1 is 56.4 (95% CI, 5.3-351.1; P = 0.001).

Cow (Bovine) Protein S (Alpha) (PROS1) Interaktionspartner

  1. Activated protein C (zeige PROC Proteine)(APC (zeige APC Proteine)) combined with protein S(PS) had significant antithrombotic effect. APC (zeige APC Proteine) combined with PS prolonged clotting time. Dependence on APC (zeige APC Proteine)-cofactor activity of PS for expression of anticoagulant activity by APC (zeige APC Proteine).

Mouse (Murine) Protein S (Alpha) (PROS1) Interaktionspartner

  1. This study identifies a duple role for PROS1 in stem-cell quiescence and as a pro-neurogenic factor, and highlights a unique segregation of increased stem cell proliferation from enhanced neuronal differentiation.

  2. Mice overexpressing protein S showed significant improvements in blood glucose level, glucose tolerance, insulin (zeige INS Proteine) sensitivity, and insulin (zeige INS Proteine) secretion compared with wild-type counterparts. diabetic protein S transgenic mice developed significantly less severe diabetic glomerulosclerosis than controls.

  3. By revealing that neural stem-like cells act within the SVZ neurogenic niche as phagocytes and that the ProS/MerTK (zeige MERTK Proteine) path represents an endogenous regulatory mechanism for SVZ cell phagocytic activity

  4. Optimal TAM (zeige CCNA1 Proteine) signaling requires coincident TAM (zeige CCNA1 Proteine) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (zeige CCNA1 Proteine) receptor tyrosine kinases Tyro3 (zeige TYRO3 Proteine), Axl (zeige AXL Proteine), and Mer (zeige ERH Proteine) and their ligands Gas6 (zeige GAS6 Proteine) and Protein S.

  5. Data indicate that activated T cells express Pros1.

  6. Results demonstrate that Protein S is a Mer (zeige ERH Proteine) ligand, and is active in Mer (zeige ERH Proteine)-driven phagocytosis in the retina.

  7. A self-regulatory mechanism of Toll (zeige TLR4 Proteine)-like receptor signalling through the suppression of Gas6 (zeige GAS6 Proteine) and ProS expression is described.

  8. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM (zeige CCNA1 Proteine) receptor Tyro3 (zeige TYRO3 Proteine) and sphingosine 1-phosphate receptor1.

  9. results demonstrate that ProS is a pleiotropic anticoagulant with activated Protein C (zeige PROC Proteine)-independent activities and highlight new roles for ProS in vascular development and homeostasis

  10. Pregnancy causes a decrease in APC (zeige APC Proteine) resistance in mice, which can be explained by the elevation of protein S levels and increased TFPI (zeige TFPI Proteine) activity in plasma.

PROS1 Protein Überblick

Protein Überblick

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3.

Genbezeichner und Symbole assoziert mit Protein S (Alpha) Proteine (PROS1)

  • protein S (pros1)
  • protein S (PROS1)
  • protein S (alpha) (Pros1)
  • protein S (Pros1)
  • AW214361 Protein
  • PROS Protein
  • PS21 Protein
  • PS22 Protein
  • PS23 Protein
  • PS24 Protein
  • PS25 Protein
  • PSA Protein
  • THPH5 Protein
  • THPH6 Protein
  • zgc:154001 Protein

Bezeichner auf Proteinebene für Protein S (Alpha) Proteine (PROS1)

vitamin K-dependent protein S , protein Sa , vitamin K-dependent plasma protein S , vitamin K-dependent protein S preproprotein

768180 Danio rerio
5627 Homo sapiens
397388 Sus scrofa
282006 Bos taurus
100009314 Oryctolagus cuniculus
19128 Mus musculus
81750 Rattus norvegicus
694845 Macaca mulatta
Ausgewählte Anbieter für PROS1 Proteine (PROS1)
Haben Sie etwas anderes gesucht?