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Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. Zusätzlich bieten wir Ihnen PPP1R1C Antikörper (32) und viele weitere Produktgruppen zu diesem Protein an.
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The data demonstrate a novel role for 8-60hIPP5(m) in the control of G2/M cell cycle progression, a process that involves the activation of ATM (zeige ATM Proteine)/p53 (zeige TP53 Proteine)/p21cip1/waf1 (zeige CDKN1A Proteine)/Cdc2 (zeige CDK1 Proteine)/ cyclin B1 (zeige CCNB1 Proteine) pathways.
IPP5 mutations are associated with response to paclitaxel in cervical cancer.
The effect of IPP5 on tumor growth and the underlying molecular mechanisms were investigated by overexpression of IPP5 in HeLa cells, a human cervical carcinoma cell line.
Overexpression of active mutant IPP5 inhibited anchorage-dependent growth and induced apoptosis in HeLa cells, which may be attributed to the up-regulation of p21 (zeige CDKN1A Proteine), p53 (zeige TP53 Proteine) and Bcl-2 (zeige BCL2 Proteine)-antagonist/killer, and down-regulation of Bcl-2 (zeige BCL2 Proteine) and Bcl-X(L (zeige BCL2L1 Proteine)).
mitochondrial signaling and ERK (zeige EPHB2 Proteine) activation may be involved in the I-1c cardioprotective effects against apoptosis induced by prolonged beta-adrenergic stimulation
Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA\; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008
PP1 inhibitor protein 5
, inhibitor-5 of protein phosphatase 1
, protein phosphatase 1 regulatory subunit 1A
, protein phosphatase 1 regulatory subunit 1C
, protein phosphatase 1 regulatory inhibitor subunit 1C L homeolog
, protein phosphatase 1, regulatory (inhibitor) subunit 1C