Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B Proteine (PPM1B)

The protein encoded by PPM1B is a member of the PP2C family of Ser/Thr protein phosphatases. Zusätzlich bieten wir Ihnen Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B Antikörper (102) und Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PPM1B 5495 O75688
PPM1B 19043 P36993
PPM1B 24667 P35815
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Showing 7 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human His-SUMO Tag   100 μg Anmelden zum Anzeigen 11 Days
$411.40
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,072.67
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,366.00
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PPM1B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B (PPM1B) Interaktionspartnern

Human Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B (PPM1B) Interaktionspartner

  1. This study has identified PPM1B and miR (zeige MLXIP Proteine)-186 as potential diagnostic markers in bladder cancer. Promotion of PPM1B and suppression of miR (zeige MLXIP Proteine)-186 may offer effective therapeutic strategies in the treatment of bladder cancer.

  2. PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing.

  3. Results identify PPM1B as a critical regulator of both p38 MAPK (zeige MAPK14 Proteine)-dependent and independent senescence pathways during normal cellular aging process.

  4. Cadmium reversed PPM1A (zeige PPM1A Proteine)-induced cell cycle arrest and cadmium insensitive PPM1A (zeige PPM1A Proteine) mutant rescued cadmium induced cell death.

  5. Protein kinase A activates NF-kappaB (zeige NFKB1 Proteine)-mediated transcription by destabilization of PP2Cbeta.

  6. the phosphatase PPM1B as a novel selective modulator of PPARgamma (zeige PPARG Proteine) activity.

  7. PPM1B functions as a TBK1 (zeige TBK1 Proteine) phosphatase dephosphorylates TBK1 (zeige TBK1 Proteine) at serine 172 and terminates TBK1 (zeige TBK1 Proteine)-mediated IRF3 (zeige IRF3 Proteine) activation and IFNbeta gene expression.

  8. Studies show that Ppm1b plays a multilayered role in regulating the availability and optimal activity of the EKLF (zeige KLF1 Proteine) protein in erythroid cells.

  9. results implicate a novel and important role for PP2Cbetal in regulating hPXR activity and CYP3A4 (zeige CYP3A4 Proteine) expression by inhibiting or desensitizing signaling pathways that negatively regulate the function of pregnane X receptor (zeige NR1I2 Proteine) in liver cells

  10. PP2Cbeta down-regulates cytokine-induced NF-kappaB (zeige NFKB1 Proteine) activation by altering IKK (zeige CHUK Proteine) activity.

Mouse (Murine) Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B (PPM1B) Interaktionspartner

  1. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 in vitro and in vivo.

  2. the phosphatase PPM1B as a novel selective modulator of PPARgamma (zeige PPARG Proteine) activity.

  3. Although a non-myristoylated mutation (G2A (zeige GPR132 Proteine)) of PPM1A (zeige PPM1A Proteine) and PPM1B prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (zeige GRK4 Proteine).

  4. These observations suggest that relatively high PP2Cbeta expression is specifically required during the early stages of pre-implantation development.

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B (PPM1B) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.

Genbezeichner und Symbole assoziert mit PPM1B

  • protein phosphatase, Mg2+/Mn2+ dependent 1B (PPM1B)
  • protein phosphatase 1B, magnesium dependent, beta isoform (Ppm1b)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1B (Ppm1b)
  • protein phosphatase, Mg2+/Mn2+ dependent 1B L homeolog (ppm1b.L)
  • protein phosphatase, Mg2+/Mn2+ dependent 1B (Ppm1b)
  • pp2c-beta-x Protein
  • Pp2c2 Protein
  • pp2cb Protein
  • pp2cbeta Protein
  • ppc2betax Protein

Bezeichner auf Proteinebene für PPM1B

PP2C-beta , protein phosphatase 1B , protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform , protein phosphatase 2C isoform beta , protein phosphatase 2C-like protein , Protein phosphatase type 1B (formely 2C) Mg-dependent beta isoform , Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform , protein phosphatase 1B, magnesium dependent, beta isoform

GENE ID SPEZIES
5495 Homo sapiens
19043 Mus musculus
24667 Rattus norvegicus
281995 Bos taurus
421404 Gallus gallus
474573 Canis lupus familiaris
443768 Xenopus laevis
100356616 Oryctolagus cuniculus
100719242 Cavia porcellus
100053585 Equus caballus
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