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The protein encoded by PPM1B is a member of the PP2C family of Ser/Thr protein phosphatases.
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This study has identified PPM1B and miR (zeige MLXIP Proteine)-186 as potential diagnostic markers in bladder cancer. Promotion of PPM1B and suppression of miR (zeige MLXIP Proteine)-186 may offer effective therapeutic strategies in the treatment of bladder cancer.
PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing.
Results identify PPM1B as a critical regulator of both p38 MAPK (zeige MAPK14 Proteine)-dependent and independent senescence pathways during normal cellular aging process.
Cadmium reversed PPM1A (zeige PPM1A Proteine)-induced cell cycle arrest and cadmium insensitive PPM1A (zeige PPM1A Proteine) mutant rescued cadmium induced cell death.
Protein kinase A activates NF-kappaB (zeige NFKB1 Proteine)-mediated transcription by destabilization of PP2Cbeta.
the phosphatase PPM1B as a novel selective modulator of PPARgamma (zeige PPARG Proteine) activity.
PPM1B functions as a TBK1 (zeige TBK1 Proteine) phosphatase dephosphorylates TBK1 (zeige TBK1 Proteine) at serine 172 and terminates TBK1 (zeige TBK1 Proteine)-mediated IRF3 (zeige IRF3 Proteine) activation and IFNbeta gene expression.
Studies show that Ppm1b plays a multilayered role in regulating the availability and optimal activity of the EKLF (zeige KLF1 Proteine) protein in erythroid cells.
results implicate a novel and important role for PP2Cbetal in regulating hPXR activity and CYP3A4 (zeige CYP3A4 Proteine) expression by inhibiting or desensitizing signaling pathways that negatively regulate the function of pregnane X receptor (zeige NR1I2 Proteine) in liver cells
PP2Cbeta down-regulates cytokine-induced NF-kappaB (zeige NFKB1 Proteine) activation by altering IKK (zeige CHUK Proteine) activity.
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 in vitro and in vivo.
Although a non-myristoylated mutation (G2A (zeige GPR132 Proteine)) of PPM1A (zeige PPM1A Proteine) and PPM1B prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (zeige GRK4 Proteine).
These observations suggest that relatively high PP2Cbeta expression is specifically required during the early stages of pre-implantation development.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.
, protein phosphatase 1B
, protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform
, protein phosphatase 2C isoform beta
, protein phosphatase 2C-like protein
, Protein phosphatase type 1B (formely 2C) Mg-dependent beta isoform
, Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform
, protein phosphatase 1B, magnesium dependent, beta isoform