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Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.
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Mutations in the protamine locus may be an infrequent cause of male infertility.
PRM3 shows several clear differences from other protamines, and it cannot be regarded as a true protamine. Among 10 mouse species, PRM3 showed weak evidence of positive selection in two species but no clear association with levels of sperm competition.
PRM3 is an acidic protein that is localized in the cytoplasm of elongated spermatids. Sperm from Prm3(-/-) males exhibited reductions in motility.
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
, sperm protamine P3