anti-Protamine 1 (PRM1) Antikörper

Human Protamine 1 (PRM1) Interaktionspartner

1. The expression level of PRM1 was significantly higher in colon cancer tissues and the staining degree of PRM1 in poorly-differentiated was stronger.

2. Bacterial infections have significant negative effects on sperm chromatin condensation and protamine P1/P2 ratio.

3. Protamine-1 and protamine-2 mRNA levels as well as the protamine mRNA ratio and all routine semen parameters revealed significant differences between recurrent miscarriage couples and healthy volunteers. Values of protamine-1 and protamine-2 mRNAs were significantly higher and the protamine mRNA ratio was significantly lower in couples with recurrent miscarriage.

4. examinded the association between protamine gene alleles (PRM1 c.-190C>A, PRM1 c.197G>T, and PRM2 c.248C>T), and YBX2 (c.187T>C and c.1095 + 16A>G) and male infertility. We found that the AA and CA genotypes of the PRM1 c.-190C>A polymorphism had a significant association with infertility (p < 0.001) and the AA genotype was also highly significantly associated with high sperm DNA damage (p < 0.001).

5. The KDM3A to PRM1 mRNA expression ratio can be used as a reliable marker of successful testicular sperm extraction in men with obstructive and non-obstructive azoospermia with 95% sensitivity.

6. Single nucleotide polymorphisms in the human PRM1 gene are associated with a genetic risk factor for idiopathic oligozoospermia.

7. Studies indicate that ribonucleotide reductase M1 polypeptide (RRM1) expression is associated with the response rate and overall survival rate of advanced NSCLC patients treated with gemcitabine-based chemotherapy.

8. The expressed human protamine1 in two fast-growing cell systems, E. coli and HeLa cells. The protamine 1 expression significantly attenuated cell proliferation when compared with control cells.

9. the quantity of PRM1, PRM2, and TNP2 transcripts and the PRM1/PRM2 mRNA ratio affect spermiogenesis, sperm morphology

10. Single nuclotide polymorphisms in PRM1 gene is associated with male infertility.

11. genetic association study in Han population in China: Data suggest that an SNP in PRM1 (rs35576928; T allele; 34R>S) is associated with severe oligozoospermia and can play a protective role against this disease.

12. The SNP of PRM1-190C- > A might be associated with teratozoospermia-induced male infertility in the Han Chinese.

13. significant correlation has been found between protamine 1 and 2 transcripts/proteins and: sperm concentration, progressive sperm motility, sperm fertilization ability as well as embryo quality

14. identified and we report for the first time five novel rare haplotypes encompassing the protamine 1 and 2 genes

15. Data suggest that Casp4, Casp 6 and TNFSF10 are differentially expressed in potentially fertile and subfertile men and represent useful biomarkers for predicting male fertility in combination with P1 and P2.

16. Mutations in the protamine locus may be an infrequent cause of male infertility.

17. single nucleotide polymorphisms in this gene in fertile and infertile males

18. A number of SNPs are present in the testis-specific nuclear protein genes.

19. The P1/P2 ratio has a significant relationship to sperm fertilization ability.

20. Mutations in PRM1 gene were identified in males with oligozoospermia.

Mouse (Murine) Protamine 1 (PRM1) Interaktionspartner

1. Data show that male mice from lines showing moderate transgene expression were fully fertile whereas strong overexpression of the Prm1-EGFP fusion protein resulted in complete and dominant male sterility.

2. docking of protamine 1 to the nuclear envelope is an important intermediate step in spermiogenesis

3. Germ cell nuclear factor acts as a repressor of basal transcription on both the Protamine 1 and Protamine 2 promoters.

4. JHDM2A directly binds to and controls the expression of transition nuclear protein 1 (Tnp1) and protamine 1 (Prm1) genes, the products of which are required for packaging and condensation of sperm chromatin

5. Study shows that protamine 1 and 2 mRNAs, which are specific to the round spermatid stage, are repressed at the two-pronuclei and two-cell stages postfertilization, respectively, in embryos created by round spermatid injection, by distinct mechanisms.

Cow (Bovine) Protamine 1 (PRM1) Interaktionspartner

1. This study was conducted to isolate high-quality RNA from mature spermatozoa and to monitor the expression profile of PRM1 and PRM2 gene in ejaculated spermatozoa of normal and motility impaired bulls.

2. the number of clustered arginine residues present in the DNA binding domain is the most important factor affecting the condensation and stability of the DNA-protamine complex prior to the formation of inter-protamine disulfide cross-links.

Pig (Porcine) Protamine 1 (PRM1) Interaktionspartner

1. Porcine spermatozoa may delivery CLU, PRM1 and PRM2 mRNAs to the oocyte, which may contribute to zygotic and early embryonic development.