anti-Protamine 1 (PRM1) Antikörper

Human Protamine 1 (PRM1) Interaktionspartner

1. Protamine-1 and protamine-2 (zeige PRM2 Antikörper) mRNA levels as well as the protamine mRNA ratio and all routine semen parameters revealed significant differences between recurrent miscarriage couples and healthy volunteers. Values of protamine-1 and protamine-2 (zeige PRM2 Antikörper) mRNAs were significantly higher and the protamine mRNA ratio was significantly lower in couples with recurrent miscarriage.

2. examinded the association between protamine gene alleles (PRM1 c.-190C>A, PRM1 c.197G>T, and PRM2 (zeige PRM2 Antikörper) c.248C>T), and YBX2 (zeige YBX2 Antikörper) (c.187T>C and c.1095 + 16A>G) and male infertility. We found that the AA and CA genotypes of the PRM1 c.-190C>A polymorphism had a significant association with infertility (p < 0.001) and the AA genotype was also highly significantly associated with high sperm DNA damage (p < 0.001).

3. The KDM3A (zeige KDM3A Antikörper) to PRM1 mRNA expression ratio can be used as a reliable marker of successful testicular sperm extraction in men with obstructive and non-obstructive azoospermia with 95% sensitivity.

4. Single nucleotide polymorphisms in the human PRM1 gene are associated with a genetic risk factor for idiopathic oligozoospermia.

5. Studies indicate that ribonucleotide reductase M1 polypeptide (RRM1 (zeige RRM1 Antikörper)) expression is associated with the response rate and overall survival rate of advanced NSCLC patients treated with gemcitabine-based chemotherapy.

6. The expressed human protamine1 in two fast-growing cell systems, E. coli and HeLa cells. The protamine 1 expression significantly attenuated cell proliferation when compared with control cells.

7. the quantity of PRM1, PRM2 (zeige PRM2 Antikörper), and TNP2 (zeige TNP2 Antikörper) transcripts and the PRM1/PRM2 (zeige PRM2 Antikörper) mRNA ratio affect spermiogenesis, sperm morphology

8. Single nuclotide polymorphisms in PRM1 gene is associated with male infertility.

9. genetic association study in Han population in China: Data suggest that an SNP in PRM1 (rs35576928; T allele; 34R>S) is associated with severe oligozoospermia and can play a protective role against this disease.

10. The SNP of PRM1-190C- > A might be associated with teratozoospermia-induced male infertility in the Han Chinese.

Mouse (Murine) Protamine 1 (PRM1) Interaktionspartner

1. Data show that male mice from lines showing moderate transgene expression were fully fertile whereas strong overexpression of the Prm1-EGFP fusion protein resulted in complete and dominant male sterility.

2. docking of protamine 1 to the nuclear envelope is an important intermediate step in spermiogenesis

3. Germ cell nuclear factor (zeige NR6A1 Antikörper) acts as a repressor of basal transcription on both the Protamine 1 and Protamine 2 (zeige PRM2 Antikörper) promoters.

4. JHDM2A (zeige KDM3A Antikörper) directly binds to and controls the expression of transition nuclear protein 1 (zeige NUPR1 Antikörper) (Tnp1 (zeige TNP1 Antikörper)) and protamine 1 (Prm1) genes, the products of which are required for packaging and condensation of sperm chromatin

5. Study shows that protamine 1 and 2 mRNAs, which are specific to the round spermatid stage, are repressed at the two-pronuclei and two-cell stages postfertilization, respectively, in embryos created by round spermatid injection, by distinct mechanisms.

Cow (Bovine) Protamine 1 (PRM1) Interaktionspartner

1. This study was conducted to isolate high-quality RNA from mature spermatozoa and to monitor the expression profile of PRM1 and PRM2 (zeige PRM2 Antikörper) gene in ejaculated spermatozoa of normal and motility impaired bulls.

Pig (Porcine) Protamine 1 (PRM1) Interaktionspartner

1. Porcine spermatozoa may delivery CLU (zeige CLU Antikörper), PRM1 and PRM2 (zeige PRM2 Antikörper) mRNAs to the oocyte, which may contribute to zygotic and early embryonic development.