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This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin.
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This study showed that COX-1 and COX-2 (zeige PTGS2 Proteine) in genital carcinomas in the horse is poor; microsomal PGES (zeige PTGES Proteine)-1 is more prominently expressed.
COX-1 and COX-2 (zeige PTGS2 Proteine) genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 (zeige PTGS2 Proteine) gene expression at each subsequent time point, compared with baseline values.
In this study, both COX-1 and COX-2 (zeige PTGS2 Proteine) were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2 (zeige PTGS2 Proteine).
Immunoreactivity for COX-1 and COX-2 (zeige PTGS2 Proteine) is high in equine corneal SCC (zeige CYP11A1 Proteine), possibly indicating that COX (zeige CPOX Proteine) plays a role in oncogenesis or progression of this tumor type at this site.
These results suggest that licochalcones inhibit collagen-induced platelet aggregation accompanied by inhibition of COX-1 activity.
IFNgamma upregulated microsomal prostaglandin E synthase-1 (mPGES-1 (zeige PTGES Proteine)) alongside cyclo-oxygenase (COX-1) within macrophage populations, resulting in sustained prostaglandin (PG)E2 biosynthesis.
Data (including data from studies in knockout mice) suggest that delayed parturition in Cox-1 knockout mice is result of impaired luteolysis and cervical dilation, despite the presence of strong uterine contractions.
Data suggest that Il4 (zeige IL4 Proteine) (usually released from helper T-cells) induces Cox1 in macrophages at post-transcriptional level; activation of Ampk (zeige PRKAA1 Proteine) (catalytic subunit Prkaa1 (zeige PRKAA1 Proteine)) by metformin blocks Il4 (zeige IL4 Proteine)-dependent induction of Cox1 and blocks macrophage polarization/activation. (Il4 (zeige IL4 Proteine) = interleukin-4 (zeige IL4 Proteine); Cox1 = cyclooxygenase 1; Ampk (zeige PRKAA1 Proteine) = AMP-activated protein kinase (zeige PRKAA2 Proteine))
Specific inhibition of PGE2 synthesis by targeting mPGES-1 (zeige PTGES Proteine) may weaken host defense against bacterial infections.
Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (zeige YWHAZ Proteine), lipoxygenase and cyclooxygenase.
role of cyclooxygenase-1 and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas
Suggest the expression of COX-1 and COX-2 in the urothelium protects bladder damage from radiation.
COX-1 inhibitor SC-560 has a protective effect on the thromboxane A2-mediated decrease in renal function in response to endotoxin.
Expression of COX-1 is essential for the protection of liver against chemical-induced hepatotoxicity and required for hepatic homeostatic maintenance.
Data suggest that multitarget FAAH (zeige FAAH Proteine)/Cox (zeige CPOX Proteine) blockade may provide a transformative approach to inflammatory bowel disease (IBD) and other pathologies in which fatty acid amide hydrolase (zeige FAAH Proteine)/cyclooxygenases (FAAH (zeige FAAH Proteine), Cox-1, and Cox-2) are overactive.
there was no expression of COX-1, either mRNA or protein, on any day of the estrous cycle
Extracellular histones disarrange vasoactive mediators release through a COX1-COX2-eNOS (zeige NOS3 Proteine) interaction in human endothelial cells.
Results suggested that in Chinese Han patients with stroke taking aspirin for secondary prevention, PTGS1 polymorphisms may increase the risk of poor functional outcomes and this effect may be modulated by the smoking status. PTGS1 gene-smoking interaction might in part reflect the heterogeneity in the prognosis of patients treated with aspirin.
analysis of co-existing variants in both F8 and PTGS-1 genes in a three-generation pedigree of hemophilia A; the PTGS-1 variant was associated with specific functional defects in the arachidonic acid pathway and more severe hemorrhage.
Data suggest expression of PTGS1 in colon is significantly correlated with expression of PTGS2 (zeige PTGS2 Proteine), PTGES1, PTGER2 (zeige PTGER2 Proteine), and PTGER4 (zeige PTGER4 Proteine); this study was conducted in individuals at high risk for colon cancer treated with Mediterranean diet versus a Healthy Eating diet for prevention of colon cancer. (PG = prostaglandin; PTGS2 (zeige PTGS2 Proteine) = PG-endoperoxide synthase 2; PTGES1 = PGE (zeige LIPF Proteine) synthase protein; PTGER2 (zeige PTGER2 Proteine) = PGE (zeige LIPF Proteine) receptor 2; PTGER4 (zeige PTGER4 Proteine) = PGE (zeige LIPF Proteine) receptor 4)
Panax quinquefolium saponin attenuated HUVEC apoptosis and improved the dual antiplatelet-mediated reduction of platelet adhesion to injured HUVECs and the underlying mechanisms may be associated with PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) and COX (zeige COX8A Proteine) pathways.
The interactions of COX (zeige COX8A Proteine)-1of rs3842787 and cox-2 of rs20417 were associated with aspirin resistance of stroke.
We provide the first report that pro-angiogenic genes PECAM1 (zeige PECAM1 Proteine), PTGS1, FGD5 (zeige FGD5 Proteine), and MCAM (zeige MCAM Proteine) may play a vital role in pathological dermal angiogenesis disorders of psoriasis.
a new neutrophil-activating platelet-derived lipid generated by COX-1 is presented that can activate or prime human neutrophils, suggesting a role in innate immunity and acute inflammation.
Seminal COX-1 is over-expressed in infertile oligoasthenoteratozoospermic (OAT (zeige OAT Proteine)) men with varicocele (Vx) compared with fertile men with/without and infertile OAT (zeige OAT Proteine) men without Vx being associated with oxidative stress, Vx grade and Vx laterality.
Brain death increases the expression of COX-1 and COX-2 (zeige PTGS2 Proteine) mRNA in the renal medulla
Endometrial prostaglandin-endoperoxide synthase 1 (PTGS1) mRNA expression increased 2- to 3-fold after Day 10 of the estrous cycle and pregnancy, whereas PTGS2 (zeige PTGS2 Proteine) mRNA expression increased 76-fold between Days 5 and 15 of the estrous cycle and pregnancy.
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.
, prostaglandin G/H synthase 1
, prostaglandin G/H synthase and cyclooxygenase
, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
, PGH synthase 1
, PHS 1
, prostaglandin H2 synthase 1
, prostaglandin-endoperoxide synthase 1
, cyclooxygenase 1
, cyclooxygenase 3
, prostaglandin endoperoxide synthase