Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) Proteine (PTGS1)

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. Zusätzlich bieten wir Ihnen PTGS1 Antikörper (183) und PTGS1 Kits (75) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTGS1 19224 P22437
PTGS1 24693 Q63921
PTGS1 5742 P23219
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Top PTGS1 Proteine auf antikoerper-online.de

Showing 8 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$822.00
Details
Escherichia coli (E. coli) Ratte His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$736.00
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$800.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$814.00
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$221.48
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,653.83
Details

PTGS1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Rat (Rattus) ,
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Human , , ,
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Weitere Proteine zu Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) Interaktionspartnern

Horse (Equine) Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) Interaktionspartner

  1. This study showed that COX-1 and COX-2 in genital carcinomas in the horse is poor; microsomal PGES-1 is more prominently expressed.

  2. COX-1 and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.

  3. In this study, both COX-1 and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.

  4. Immunoreactivity for COX-1 and COX-2 is high in equine corneal SCC, possibly indicating that COX plays a role in oncogenesis or progression of this tumor type at this site.

Rabbit Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) Interaktionspartner

  1. These results suggest that licochalcones inhibit collagen-induced platelet aggregation accompanied by inhibition of COX-1 activity.

Mouse (Murine) Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) Interaktionspartner

  1. IFNgamma upregulated microsomal prostaglandin E synthase-1 (mPGES-1) alongside cyclo-oxygenase (COX-1) within macrophage populations, resulting in sustained prostaglandin (PG)E2 biosynthesis.

  2. Data (including data from studies in knockout mice) suggest that delayed parturition in Cox-1 knockout mice is result of impaired luteolysis and cervical dilation, despite the presence of strong uterine contractions.

  3. Data suggest that Il4 (usually released from helper T-cells) induces Cox1 in macrophages at post-transcriptional level; activation of Ampk (catalytic subunit Prkaa1) by metformin blocks Il4-dependent induction of Cox1 and blocks macrophage polarization/activation. (Il4 = interleukin-4; Cox1 = cyclooxygenase 1; Ampk = AMP-activated protein kinase)

  4. Specific inhibition of PGE2 synthesis by targeting mPGES-1 may weaken host defense against bacterial infections.

  5. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2, lipoxygenase and cyclooxygenase.

  6. role of cyclooxygenase-1 and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas

  7. Suggest the expression of COX-1 and COX-2 in the urothelium protects bladder damage from radiation.

  8. COX-1 inhibitor SC-560 has a protective effect on the thromboxane A2-mediated decrease in renal function in response to endotoxin.

  9. Expression of COX-1 is essential for the protection of liver against chemical-induced hepatotoxicity and required for hepatic homeostatic maintenance.

  10. Data suggest that multitarget FAAH/Cox blockade may provide a transformative approach to inflammatory bowel disease (IBD) and other pathologies in which fatty acid amide hydrolase/cyclooxygenases (FAAH, Cox-1, and Cox-2) are overactive.

  11. In arteries from non-insulin-dependent diabetic mice, COX-1 remains a major contributor to the endothelial PGI2 synthesis that evokes vasoconstrictor activity under the pathological condition.

  12. specific inhibition of mmu-miR-100-5p significantly enhanced expression of Il6, Ptgs1/2 and Tlr4 mRNA

  13. COX1/2-derived prostanoids appear to play an important role in the TLR response, with elevated cytokine levels following COX1/2 inhibition or genetic deletion.

  14. Data suggest deletion of Cox1 delays ovarian follicle development prior to reproductive maturation of mutant mouse strain (Wv); inhibition of Cox1 (but not Cox2) may prolong ovarian follicle lifespan and delay the onset of premature ovarian failure.

  15. role of COX-1 during maturation of adipocyte

  16. The production of prostanoids found in the systemic circulation is driven overwhelmingly by COX-1 and not COX-2.

  17. Prostaglandin G/H synthase is a moonlighting protein that functions both as a peroxidase as well as a cyclooxygenase.

  18. Hematopoietic COX-1 deletion results in impairments in metabolic homeostasis which may be partly due to increased adipose tissue inflammation and dysregulated adipokine profile.

  19. Propose a mechanism whereby ANG II increases COX-1-derived PGE2 through the AT1R/PLA2 pathway, which promotes ROS production by EP1R/Nox2 signaling in the subfornical organ.

  20. These observations suggest that COX-enzymes, most likely COX-1, are involved in cancer-elicited anorexia and weight loss

Cow (Bovine) Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) Interaktionspartner

  1. there was no expression of COX-1, either mRNA or protein, on any day of the estrous cycle

Human Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) Interaktionspartner

  1. COX1 inhibition significantly triggered cell death.

  2. Prostaglandin D2 generation from human lung mast cells is catalysed exclusively by cyclooxygenase-1

  3. Extracellular histones disarrange vasoactive mediators release through a COX1-COX2-eNOS interaction in human endothelial cells.

  4. Results suggested that in Chinese Han patients with stroke taking aspirin for secondary prevention, PTGS1 polymorphisms may increase the risk of poor functional outcomes and this effect may be modulated by the smoking status. PTGS1 gene-smoking interaction might in part reflect the heterogeneity in the prognosis of patients treated with aspirin.

  5. analysis of co-existing variants in both F8 and PTGS-1 genes in a three-generation pedigree of hemophilia A; the PTGS-1 variant was associated with specific functional defects in the arachidonic acid pathway and more severe hemorrhage.

  6. Data suggest expression of PTGS1 in colon is significantly correlated with expression of PTGS2, PTGES1, PTGER2, and PTGER4; this study was conducted in individuals at high risk for colon cancer treated with Mediterranean diet versus a Healthy Eating diet for prevention of colon cancer. (PG = prostaglandin; PTGS2 = PG-endoperoxide synthase 2; PTGES1 = PGE synthase protein; PTGER2 = PGE receptor 2; PTGER4 = PGE receptor 4)

  7. Epithelial Cells Induce a Cyclo-Oxygenase-1-Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype

  8. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2, lipoxygenase and cyclooxygenase.

  9. Panax quinquefolium saponin attenuated HUVEC apoptosis and improved the dual antiplatelet-mediated reduction of platelet adhesion to injured HUVECs and the underlying mechanisms may be associated with PI3K/AKT and COX pathways.

  10. The interactions of COX-1of rs3842787 and cox-2 of rs20417 were associated with aspirin resistance of stroke.

  11. Results show a trend toward an association between rs1236913 SNP and worst pain scores on nonsurgical root canal therapy post-treatment day 1

  12. We provide the first report that pro-angiogenic genes PECAM1, PTGS1, FGD5, and MCAM may play a vital role in pathological dermal angiogenesis disorders of psoriasis.

  13. a new neutrophil-activating platelet-derived lipid generated by COX-1 is presented that can activate or prime human neutrophils, suggesting a role in innate immunity and acute inflammation.

  14. Seminal COX-1 is over-expressed in infertile oligoasthenoteratozoospermic (OAT) men with varicocele (Vx) compared with fertile men with/without and infertile OAT men without Vx being associated with oxidative stress, Vx grade and Vx laterality.

  15. variable turnover rate represents the most convincing determinant of the inter-individual variability in response to aspirin for primary prevention in diabetes mellitus

  16. In Indian peptic ulcer hemorrhage patients, those with Cox-1 A842G polymorphisms tended to have less gastric ulcers among those with the A842G/C50T polymorphism.

  17. single nucleotide polymorphisms show a protective effect under a dominant model of diisocyanate-induced asthma

  18. inverse allosteric regulation likely underlies the ability of PGHS-2 to operate at low AA concentrations, when PGHS-1 is effectively latent.

  19. PON1, P2Y12 and COX1 polymorphisms were associated with poorer vascular outcomes in patients with extracranial or intracranial stents.

  20. The regulation of important oxylipin metabolic genes in peripheral blood mononuclear cells varied with the extent of change in arachidonic acid concentrations in the case of PTGS1 and ALOX12 regulation.

Pig (Porcine) Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) Interaktionspartner

  1. Brain death increases the expression of COX-1 and COX-2 mRNA in the renal medulla

  2. Endometrial prostaglandin-endoperoxide synthase 1 (PTGS1) mRNA expression increased 2- to 3-fold after Day 10 of the estrous cycle and pregnancy, whereas PTGS2 mRNA expression increased 76-fold between Days 5 and 15 of the estrous cycle and pregnancy.

PTGS1 Protein Überblick

Protein Überblick

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit PTGS1

  • prostaglandin-endoperoxide synthase 1 (PTGS1)
  • cyclooxygenase-1 (cox-1)
  • prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1)
  • prostaglandin-endoperoxide synthase 1 (Ptgs1)
  • prostaglandin-endoperoxide synthase 1 (ptgs1)
  • prostaglandin-endoperoxide synthase 1 S homeolog (ptgs1.S)
  • Cox-1 Protein
  • COX-3 Protein
  • cox1 Protein
  • COX3 Protein
  • PCOX1 Protein
  • PES-1 Protein
  • PGG/HS Protein
  • PGHS-1 Protein
  • PGHS1 Protein
  • PHS 1 Protein
  • PHS1 Protein
  • PTGHS Protein
  • Ptgs1 Protein
  • zCOX-1 Protein

Bezeichner auf Proteinebene für PTGS1

cyclooxygenase-1 , prostaglandin G/H synthase 1 , prostaglandin G/H synthase and cyclooxygenase , prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) , PGH synthase 1 , PGHS-1 , PHS 1 , prostaglandin H2 synthase 1 , prostaglandin-endoperoxide synthase 1 , cyclooxygenase 1 , COX-1 , cyclooxygenase 3 , Cox-1 , Cox-1b , prostaglandin endoperoxide synthase , cyclooxygenase

GENE ID SPEZIES
100034087 Equus caballus
100136038 Oncorhynchus mykiss
427752 Gallus gallus
464713 Pan troglodytes
698213 Macaca mulatta
100585600 Nomascus leucogenys
100009407 Oryctolagus cuniculus
19224 Mus musculus
24693 Rattus norvegicus
246226 Danio rerio
282022 Bos taurus
5742 Homo sapiens
443551 Ovis aries
403544 Canis lupus familiaris
397541 Sus scrofa
100037245 Xenopus laevis
Ausgewählte Anbieter für PTGS1 Proteine (PTGS1)
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