Poly A Specific Ribonuclease Proteine (PARN)

The protein encoded by PARN is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. Zusätzlich bieten wir Ihnen PARN Antikörper (68) und PARN Kits (13) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PARN 5073 O95453
Ratte PARN PARN 360464  
PARN 74108 Q8VDG3
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Top PARN Proteine auf antikoerper-online.de

Showing 8 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$860.20
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 11 Days
$411.40
Details
Hefe Human His tag   100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$484.00
Details
Escherichia coli (E. coli) Human GST tag,S tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$656.00
Details
Insect cells (Sf9) Human His tag   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$4,323.08
Details

PARN Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, , ,
Mouse (Murine)

Weitere Proteine zu Poly A Specific Ribonuclease (PARN) Interaktionspartnern

Human Poly A Specific Ribonuclease (PARN) Interaktionspartner

  1. Studies suggest that the effects of poly(A)-specific ribonuclease (PARN) mutations on telomere length are likely indirect and may lead to telomere shortening that less perfectly cosegregates with heterozygous mutations.

  2. Pulmonary fibrosis patients with mutations in telomerase reverse transcriptase (zeige TERT Proteine), telomerase RNA component, regulator of telomere elongation helicase 1 and poly(A)-specific ribonuclease were identified and clinical data were analysed. Genetic mutations in telomere related genes lead to a variety of interstitial lung disease diagnoses that are universally progressive.

  3. PARN polyadenylates the 3' end of telomerase RNA component (known as TERC or hTR (zeige F2R Proteine)), which serves as the template for telomerase reverse transcriptase (zeige TERT Proteine)-mediated telomere replication.

  4. PARN is a new component of the ribosome biogenesis machinery in human cells.

  5. provide evidence that PARN can also deadenylate the U6 and RMRP (zeige NME1 Proteine) RNAs without affecting their levels

  6. poly(A)-specific ribonuclease (PARN) participates in steps leading to 18S pre-rRNA maturation in human cells

  7. we found a polyadenylation-dependent 3' end maturation pathway for the human telomerase RNA that relies on the nuclear poly(A)-binding protein PABPN1 (zeige PABPN1 Proteine) and the poly(A)-specific RNase PARN.

  8. PARN increased telomerase RNA component levels by deadenylating telomerase RNA component, thereby limiting its degradation by EXOSC10 (zeige EXOSC10 Proteine).

  9. Large monoallelic mutations of PARN can cause developmental/mental illness. Biallelic PARN mutations cause severe bone marrow failure and central hypomyelination.

  10. results highlight the clinical significance of PARN and NOC on the survival in SCC (zeige CYP11A1 Proteine) diagnosed patients.

Mouse (Murine) Poly A Specific Ribonuclease (PARN) Interaktionspartner

  1. these data indicate that PARN modulates decay of a defined set of mRNAs in mammalian cells and implicate this deadenylase in coordinating control of genes required for cell movement.

  2. poly(A) polymerase (zeige PAPOLA Proteine) Gld2 (zeige PAPD4 Proteine), deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd (zeige NGDN Proteine)) are components of a dendritic CPEB (zeige CPEB1 Proteine)-associated polyadenylation apparatus

  3. Solution structures of the cap-binding domain of mouse PARN with and without the m(7)GpppG cap analog reveal a novel cap-binding mode.

  4. A modeled PARN, which shows that the RRM domain from one subunit and the R3H domain from the other subunit enclose the active site.

PARN Protein Überblick

Protein Überblick

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit PARN

  • poly(A)-specific ribonuclease L homeolog (parn.L)
  • poly(A)-specific ribonuclease (PARN)
  • poly(A)-specific ribonuclease (Parn)
  • poly(A)-specific ribonuclease (deadenylation nuclease) (parn)
  • poly(A)-specific ribonuclease (deadenylation nuclease) (Parn)
  • 1200003I18Rik Protein
  • DAN Protein
  • parn-A Protein
  • RGD1565449 Protein
  • xparn Protein
  • zgc:56067 Protein

Bezeichner auf Proteinebene für PARN

deadenylating nuclease , deadenylation nuclease , poly(A)-specific ribonuclease (deadenylation nuclease) , poly(A)-specific ribonuclease PARN , polyadenylate-specific ribonuclease

GENE ID SPEZIES
394409 Xenopus laevis
5073 Homo sapiens
479839 Canis lupus familiaris
524155 Bos taurus
360464 Rattus norvegicus
100172259 Pongo abelii
791461 Danio rerio
74108 Mus musculus
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