Plexin B1 Proteine (PLXNB1)

Receptor for SEMA4D. Zusätzlich bieten wir Ihnen Plexin B1 Antikörper (72) und Plexin B1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PLXNB1 235611 Q8CJH3
Ratte PLXNB1 PLXNB1 316009  
PLXNB1 5364 O43157
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Top Plexin B1 Proteine auf

Showing 4 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg 15 bis 18 Tage
Escherichia coli (E. coli) Maus T7 tag,His tag 100 μg 15 bis 18 Tage

PLXNB1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
Human ,

Weitere Proteine zu Plexin B1 (PLXNB1) Interaktionspartnern

Mouse (Murine) Plexin B1 (PLXNB1) Interaktionspartner

  1. These results demonstrate a novel physiological function for sema4D/plxnB1 signaling in retinal pigment epithelium phagocytosis.

  2. Plexin-B1 coordinates cell repolarization through RhoA-ROCK-mediated redistribution of Plexin-B1.

  3. Plexin-B1 and -B2 play redundant or compensatory roles during forebrain development to ensure proper neuronal production and neocortical expansion.

  4. Deletion of plexin-B1, the high affinity receptor for semaphorin 4D, significantly (one-way ANOVA; p < 0.001) reduced thrombus weight (- 40%) in oxidative venous thrombosis.

  5. Sema 4D/CD100 is not only a ligand for plexin B1 but also a direct signaling receptor in mediating Sema 4D/CD100-plexin B's biological functions.

  6. In ErbB-2-overexpressing murine breast cancer, ablation of Plexin-B1 genes strongly reduced metastases. Plexin-B1 has no effect on tumorigenesis or tumor growth but is required for metastasis of ErbB-2-dependent breast cancers in vivo.

  7. Semaphorin 4D-induced nitric oxide synthase (iNOS) and nitric oxide (NO) production are mediated through plexin-B1.

  8. a lack of plexin-B1 did not impact on cortical development in vivo

  9. LARG plays a critical role in plexin-B1 signaling to stimulate Rho activation and cytoskeletal reorganization.

  10. binding of Sema 4D to Plexin B1 stimulates the tyrosine kinase activity of Met

  11. Results suggest that plexin-A1 and B1 interact in the adult brain and transduce semaphorin 3A signaling in cooperation.

  12. Plexin signaling uncouples cell substrate-adhesion from cytoskeletal dynamics required for cell migration and axon extension.

  13. The mechanism of semaphorin D in the activation of the MAPK pathway via plexin-B1 is reported.

  14. A possible role for plexin-B1 in ovarian follicle growth and steroidogenesis, most likely via the granulosa cells, is suggested.

  15. In the ovarian follicle, the effect of Plexin-B1 is mediated by semaphorin-4D.

  16. PlexinB1 plays a redundant role in mouse development and it is not strictly required for tumour induced angiogenesis

  17. A loss of plexin-B1 expression in mice does not significantly impact the development of the nervous system.

  18. A functional role for CD100 antigen/Plxnb1 interactions in epithelial branching morphogenesis during organogenesis is reported.

  19. B-Raf/MKK/ERK provides a permissive environment for melanoma genesis by modulating plexin B1.

Human Plexin B1 (PLXNB1) Interaktionspartner

  1. Plexin-B1 level showed a significant positive correlation both with overall survival and disease free survival of Caucasian breast cancer patients

  2. Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins shows lack of binding specificity.

  3. The positive expression of both Sema4D and PlexinB1 was found to be an independent risk factor for a worse survival in colorectal cancer.

  4. Loss of plexin B1 expression might play a pivotal role in enhancing the metastatic potential of breast cancer cells.

  5. Plexin B1 expression was regulated by TMPRSS2-ERG fusion gene in prostate cancer.

  6. Plexin-B1 mediates RhoA/integrin alphavbeta3 involved in the PI3K/Akt pathway and SRPK1 to influence the growth of glioma cell, angiogenesis, and motility in vitro and in vivo.

  7. results show that Sema4D/plexin-B1 signaling promotes the translocation of androgen receptor to the nucleus and thereby enhances AR transcriptional activity

  8. Plexin-B1 induces cutaneous squamous cell carcinoma cell proliferation, migration, and invasion by interacting with Sema4D. Plexin-B1 might serve as a useful biomarker and/or as a novel therapeutic target for cSCC.

  9. Results show that decreased expression of Sema4D, plexin-B1 and -B2 was associated with local recurrence and poor prognosis of breast neoplasm.

  10. Dysregulation of the vascular endothelial growth factor and semaphorin ligand-receptor families in prostate cancer metastasis

  11. Blocking of CD100, plexin B1 and/or B2 in adhesion experiments have shown that both CD100 and plexins act as adhesion molecules involved in monocyte-endothelial cell binding.

  12. The Semaphorin 4D-Plexin-B1-RhoA signaling axis recruits pericytes and regulates vascular permeability through endothelial production of PDGF-B and ANGPTL4.

  13. Activation of endogenous plexin-B1 enhances cell migration and tumor invasiveness in prostate cancer cells.

  14. Data indicate that Rnd1 efficiently displaces Rac1 from its complex with Plexin-B1 but not vice versa.

  15. ErbB-2 overexpression in human breast & ovarian cancer cell lines leads to phosphorylation & activation of Plexin-B1. This was required for ErbB-2-dependent activation of RhoA & RhoC & promoted invasive behavior.

  16. PlexinB1 mutations block plexinB1-mediated signalling pathways that inhibit cell motility.

  17. evidence that Sema4D/Plexin-B1-mediated NF-kappaB activation and IL-8 production is critical in the generation a pro-angiogenic phenotype in endothelial cells

  18. Two crystal structures of the human Plexin-B1 cytoplasmic region in complex with a constitutively active RhoGTPase, Rac1, are reported.

  19. The binding of Sema4D to plexinB1 induced small GTPase Ras homolog gene family, member A activation and resulted in the phosphorylation of MAPK and Akt.

  20. plexin-B1, a target of miR-214, may function as an oncogene in human cervical cancer HeLa cells

Plexin B1 (PLXNB1) Protein Überblick

Protein Überblick

Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.

Genbezeichner und Symbole assoziert mit Plexin B1 Proteine (PLXNB1)

  • SET domain containing 5 (SETD5)
  • plexin B1 (PLXNB1)
  • plexin b1a (plxnb1a)
  • plexin B1 (Plxnb1)
  • 2900002G15Rik Protein
  • AU042020 Protein
  • im:7054247 Protein
  • mKIAA0407 Protein
  • PLEXIN-B1 Protein
  • PLXN5 Protein
  • SEP Protein
  • si:ch211-220i18.5 Protein
  • wu:fb83a09 Protein

Bezeichner auf Proteinebene für Plexin B1 Proteine (PLXNB1)

plexin B1 , plexin b1 , plexin-B1-like , plexin-B1 , plexin 5 , semaphorin receptor SEP

416046 Gallus gallus
460344 Pan troglodytes
561012 Danio rerio
709802 Macaca mulatta
100023271 Monodelphis domestica
100053891 Equus caballus
100078327 Ornithorhynchus anatinus
100342042 Oryctolagus cuniculus
100479690 Ailuropoda melanoleuca
100589890 Nomascus leucogenys
235611 Mus musculus
316009 Rattus norvegicus
5364 Homo sapiens
476636 Canis lupus familiaris
100522643 Sus scrofa
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