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Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho).
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CpG sites located in PHOSPHO1 gene showed differential methylation in association with lipid traits. Genetic variants in PHOSPHO1 gene were also associated with lipid profile.
DNA methylation (zeige HELLS Proteine) at the PHOSPHO1 locus cg02650017 in blood DNA was associated with a decreased risk for future type 2 diabetes.
REVIEW: role of bone-type tissue-nonspecific alkaline phosphatase (zeige ALPL Proteine) and PHOSPO1 in vascular calcification
Models of PHOSPHO2 (zeige PHOSPHO2 Proteine) and PHOSPHO1 suggest subtle differences in the charge distributions around the putative substrate entry site and in the location of potential H-bond donors.
The identification of a novel, alternatively spliced PHOSPHO1 transcript (PHOSPHO1-3a), was described.
Osteoclastic resorption of the uncalcified matrix in Phospho1 KO mice was attenuated compared with surrounding normally mineralised bone
These data support the involvement of phosphate transporter 1 (zeige SLC20A1 Proteine), hereafter referred to as Pi T-1, in the initiation of skeletal mineralization and provide compelling evidence that PHOSPHO1 function is involved in MV biogenesis
Deficiency in PHOSPHO1 exerts modifications in bone architecture that are transient and depend upon age.
ablation of the OPN (zeige SPP1 Proteine) gene, Spp1 (zeige SPP1 Proteine), leads to improvements in the skeletal phenotype in Phospho1(-/-) as they age
mineralization abnormalities of dentin; reduced overall mineralization with decreased matrix vesicle mineralization in the Phospho1(-/-) mice; almost complete absence of matrix vesicles in mice; further reduction in mineralization.
PHOSPHO1 plays a critical role in vascular smooth muscle cell mineralization.
Phospho1(-/-) bones are hypomineralized and, consequently, are softer and more flexible.
phospho1 has a role in initiation of skeletal calcification
The lack of PHOSPHO1 affected ATP hydrolysis via a secondary reduction in the levels of TNAP (zeige ALPL Proteine) in PHOSPHO1-deficient matrix vesicles.
PHOSPHO1 localization is restricted to mineralizing regions of bone and growth plate
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
phosphatase, orphan 1
, phosphatase, orphan 1 like
, probable phosphatase phospho1
, phosphoethanolamine/phosphocholine phosphatase
, putative phosphatase