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PAX4 is a member of the paired box (PAX) family of transcription factors.
Showing 10 out of 69 products:
Human Monoclonal PAX4 Primary Antibody für ELISA, WB - ABIN969341
Zhang, Xiao, Liu, Zhu, Wenhui, Li, Yuan, Wang: The association of the PAX4 gene with type 1 diabetes in Han Chinese. in Diabetes research and clinical practice 2008
Cow (Bovine) Polyclonal PAX4 Primary Antibody für WB - ABIN2779444
Zhang, Smyrk, Oliveira, Lohse, Zhang, Johnson, Lloyd: KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers. in The American journal of surgical pathology 2010
Human Polyclonal PAX4 Primary Antibody für ELISA, EIA - ABIN4343820
Haaland, Scaduto, Maldonado, Mansouri, Nalini, Iyer, Patel, Guthikonda, Hampe, Balasubramanyam, Metzker: A-beta-subtype of ketosis-prone diabetes is not predominantly a monogenic diabetic syndrome. in Diabetes Care 2009
Study identified the association of a PAX4 Asian-specific missense variant rs2233580 with type 2 diabetes in an exome-chip association analysis, supporting the involvement of PAX4 in the pathogenesis of type 2 diabetes.
Viability of beta-cell was reduced under glucotoxic stress condition for the cells overexpressing either PAX4 R192H or PAX4 P321H or both. Thus these PAX4 polymorphisms may increase T2D risk by defective transcription regulation of target genes and/or decreased beta-cell survival in high glucose condition.
PAX4 IVS7-1G>A contributes to the pathogenesis of diabetes in this maturity-onset diabetes of the young, type 9 family through beta-cell dysfunction
The PAX4 variant rs6467136 was associated with the therapeutic effect of rosiglitazone in Chinese T2DM patients.
PAX4-miR (zeige MLXIP Antikörper)-144/451-ADAMs axis regulates human epithelial cancer metastasis
These data suggest that acute PAX4 overexpression can reduce expression of aristaless related homeobox and glucagon (zeige GCG Antikörper) during embryonic stem cell differentiation resulting in improved numbers of unihormonal insulin (zeige INS Antikörper)-positive cells.
Tph1 (zeige TPH1 Antikörper) and increased EC cell number occurred before the onset of obesity and hyperleptinemi. In addition, leptin (zeige LEP Antikörper) deficiency was associated with reduced Pax4 mRNA, oral leptin (zeige LEP Antikörper) treatment enhanced both Tph1 (zeige TPH1 Antikörper) and Pax4 mRNA.
MAFA (zeige KLRG1 Antikörper) nuclear expression in pancreatic alpha and beta cells, and the percentage of alpha cells expressing PAX4 are altered in patients with type 2 diabetes.
PAX4 R192H polymorphism generated a protein with defect in transcriptional repressor activities on its target genes, which may lead to beta-cell dysfunction associated with maturity onset diabetes of the young and early onset-age of type 2 diabetes.
A1168C polymorphism in PAX4 gene may not play an essential role in the genetic susceptibility of the islet autoantibody-negative ketosis-prone diabetes in Chinese Han population.
Down-regulation of PAX4 or its target gene encoding the p97/VCP (zeige vcp Antikörper) ATPase (zeige DNAH8 Antikörper) reduced myofibril disassembly.
Ectopic expression of Pax4 in pancreatic delta cells results in beta-like cell neogenesis.
The coordinated regulation of distinct cellular pathways particularly related to ER homeostasis by PAX4 not achieved by the mutant variant PAX4R129W alleviates beta cell degeneration and protects against diabetes mellitus.
This work establishes the existence of a bona fide PAX4-enriched cell subpopulation nested within pancreatic islets that can expand in periods of increased functional demands, and exhibit improved viability in response to pathophysiological situations.
Pax4 expression is not sufficient to transduce pancreatic alpha cells into beta cells. Overexpression of Pax4 in alpha cells may not increase functional beta cell number in diabetic patients
Adult glucagon (zeige GCG Antikörper) producing cells can be converted into beta-like cells upon Pax4 misexpression.
RBM4 (zeige RBM4 Antikörper) promoted insulin (zeige INS Antikörper) gene expression by altering the isoform balance of the transcription factors Isl1 (zeige ISL1 Antikörper) and Pax4 via alternative splicing control.
these finding demonstrate that, downstream of Neurog3 (zeige NEUROG3 Antikörper), the specification of a subset of enteroendocrine subtypes relies on both Arx and Pax4, while others depend only on Arx or Pax4.
Pax4 protects adult islets from stress-induced apoptosis by suppressing selective nuclear factor-kappaB target genes while increasing Bcl-2 (zeige BCL2 Antikörper) levels.
Pax4 has a role in facilitating embryonic stem cell differentiation into the pancreatic lineage
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.
paired box gene 4
, paired box protein Pax-4
, paired domain gene 4
, paired box 4
, paired-box gene 4
, paired box protein Pax-4-like