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The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]).
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Mouse (Murine) Polyclonal POU2F1 Primary Antibody für WB - ABIN2780176
Tantin, Schild-Poulter, Wang, Haché, Sharp: The octamer binding transcription factor Oct-1 is a stress sensor. in Cancer research 2005
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Human Monoclonal POU2F1 Primary Antibody für ELISA, WB - ABIN519045
Sánchez, Palomino-Morales, Ortego-Centeno, Jiménez-Alonso, González-Gay, López-Nevot, Sánchez-Román, de Ramón, González-Escribano, Pons-Estel, DAlfonso, Sebastiani, Alarcón-Riquelme, Martín: Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus. in Human molecular genetics 2009
our results indicate that POU2F1 over-expression is positively associated with aggressive phenotypes and poor survival in patients with HCC (zeige FAM126A Antikörper), and POU2F1 regulated by AKT (zeige AKT1 Antikörper) pathway promotes HCC (zeige FAM126A Antikörper) aggressive phenotypes by regulating the transcription of EMT (zeige ITK Antikörper) genes.
A significant influence of OCT1 mRNA expression on the clinical outcome of the disease was observed.
Children with certain OCT1 genotypes have higher risk for respiratory depression and nausea and vomiting, postoperatively, following morphine administration.
High POU2F1 expression is associated with liver cancer.
THE results of this investigation demonstrate that genetic polymorphisms in the hepatic uptake transporter OCT1 affect the pharmacokinetics and efficacy of tramadol.
Hepatic distribution of metformin was significantly reduced after oral administration in individuals with genetic polymorphisms in OCT1.
hOCT1 mRNA expression may serve as a clinical biomarker of response to imatinib and could be useful to predict Imatinib mesylate therapy outcome of chronic myeloid leukemia (zeige BCL11A Antikörper) patients
ABCB1 (zeige ABCB1 Antikörper) and OCT1 mRNA expressions may present biological relevance to identify responder and non-responder patients to imatinib treatment
Our study demonstrates that the existence of Oct-1 isoforms which vary in length and sequence at the N-terminus of the protein, also contributes in surprising diversity of Oct-1 functions in transcription regulation.
HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region
identified Oct-1 (POU2f1), a POU transcription factor (zeige POU2F3 Antikörper), as a downstream target of Notch (zeige NOTCH1 Antikörper) signaling by microarray based screen
In embryonic stem cells, Oct1 co-occupies a specific set of targets with Oct4 (zeige POU5F1 Antikörper), but does not occupy differentially expressed developmental targets. Instead, Oct1 occupies these targets as cells differentiate and Oct4 (zeige POU5F1 Antikörper) declines.
At low oxLDL levels LOX-1 activates the protective Oct-1/SIRT1 pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 pathway.
Study conclude that pentamidine interacts with multiple transporters, is taken into brain endothelial cells by OCT1 transporter and is extruded into the blood by ATP-dependent mechanisms. These interactions along with the predominant presence of OCT1 in the luminal membrane of the BBB (zeige ALMS1 Antikörper) contribute to the limited entry of pentamidine into the brain.
These results suggest that Oct-1 and GATA-3 (zeige GATA3 Antikörper)/Oct-2 direct Th2 cytokine gene expression in a cooperative manner.
Findings indicate octamer transcription factor-1 (zeige HNF1A Antikörper) (Oct1) and Oct binding factor 1 (zeige POU2AF1 Antikörper) protein (OCA-B (zeige POU2AF1 Antikörper)) as central mediators of CD4 (zeige CD4 Antikörper)(+) T cell memory.
levels of microRNA-451 (miR (zeige MLXIP Antikörper)-451) are negatively regulated through the phosphorylation and inactivation of its direct transcriptional activator OCT1 by 5' AMP-activated protein kinase (zeige PRKAA2 Antikörper)
Oct1 mRNA expression was decreased in mice with both ob/ob and methionine/choline deficiency models of nonalcoholic steatohepatitis.
OCT1 is a driver of synbindin (zeige TRAPPC4 Antikörper)-mediated ERK (zeige EPHB2 Antikörper) signalling and a promising marker for the prognosis and molecular subtyping of gastric cancer.
studies implicate OCT1 as well as metformin in thiamine disposition, suggesting an intriguing and parallel mechanism for metformin and its major hepatic transporter in metabolic function.
Th17 lineage differentiation is restrained by the Th2 locus via interchromosomal associations organized by Oct-1 and CTCF (zeige CTCF Antikörper).
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993
POU class 2 homeobox 1
, POU domain, class 2, transcription factor 1
, Octamer-binding transcription factor-1
, octamer-binding protein 1
, octamer-binding transcription factor 1
, octamer-binding protein (Oct-1)
, octamer binding protein 1
, maternal transcription factor
, ubiquitous transcription factor