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The protein encoded by PHF8 is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. Zusätzlich bieten wir Ihnen PHF8 Antikörper (33) und PHF8 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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PHD zinc finger 8 protein (Phf8) knockout mice display normal brain development but impaired learning and memory, and compromised long-term potentiation (LTP (zeige SCP2 ELISA Kits)) in the hippocampus.
knockdown of pmaip1 (zeige PMAIP1 ELISA Kits) mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment.
PHF8 overexpression reversed cardiac dysfunction, hypertrophy and fibrosis upon pressure overload in PHF8 transgenic mice.
The gene knockdown of PHF8 in (zeige MBD2 ELISA Kits) mouse embryonic carcinoma P1 (zeige RARA ELISA Kits)9 cells impairs RA-induced neuronal differentiatio (zeige DLG3 ELISA Kits)n.
an important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate
Our data reveal novel mechanisms that underlie the regulation of PHF8 and KDM3A during NED and in CRPC, and support the candidacy of PHF8 as a therapeutic target in CRPC.
Thus, PHF8 forms a positive feedback loop with the MEK (zeige MAP2K1 ELISA Kits)/ERK (zeige EPHB2 ELISA Kits) pathway, and PHF8 knockdown enhances the lethality of PD184352 in ALL cells. In conclusion, this study identifies oncogenic functions of PHF8 in adult ALL and suggests a novel epigenetic strategy for disease intervention.
Knockdown or knockout of PHF8 by RNAi or CRISPR-Cas9 system reduced the activation of HIF1alpha (zeige HIF1A ELISA Kits).
USP7 promotes breast carcinogenesis by stabilizing PHF8 and upregulating cyclin A2 (zeige CCNA2 ELISA Kits). and the interaction between USP7 and PHF8 is augmented during DNA damage.
PHF8 reduces the H3K9me2 level at the E2F4 (zeige E2F4 ELISA Kits) transcriptional start site, demonstrating a direct function of PHF8 in endothelial E2F4 (zeige E2F4 ELISA Kits) gene regulation
PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1.
PHF8 promotes lung cancer cell growth and survival by regulating miR (zeige MLXIP ELISA Kits)-21.
knockdown of PHF8 led to a reduction in the number of migratory and invasive cells. Furthermore, downregulation of PHF8 attenuated the tumorigenicity of ESCC cells in vivo.
PHF8 is regulated by APC (zeige APC ELISA Kits)(cdc20 (zeige CDC20 ELISA Kits)) and plays an important role in the G2/M transition.
study identified the histone demethylase (zeige MBD2 ELISA Kits) PHF8 as a coactivator that is specifically recruited by RAR-alpha (zeige RARA ELISA Kits) fusions to activate expression of their downstream targets upon all-trans retinoic acid treatment in acute promyelocytic leukemia (zeige PML ELISA Kits)
PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene.
histone lysine demethylase PHF8
, jumonji C domain-containing histone demethylase 1F