Ornithine Decarboxylase 1 Proteine (ODC1)

ODC1 encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. Zusätzlich bieten wir Ihnen Ornithine Decarboxylase 1 Antikörper (326) und Ornithine Decarboxylase 1 Kits (64) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ODC1 4953 P11926
ODC1 24609 P09057
ODC1 18263 P00860
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Human His tag,T7 tag   50 μg Anmelden zum Anzeigen 4 Days
Escherichia coli (E. coli) Human GST tag Ornithine Decarboxylase 1 (ODC1) (AA 1-461), (full length) protein (GST tag) 1 mg Anmelden zum Anzeigen 60 bis 71 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Nematode His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Caenorhabditis elegans His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Trypanosoma brucei His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

ODC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , , ,
Rat (Rattus) ,
Mouse (Murine) ,

Weitere Proteine zu Ornithine Decarboxylase 1 (ODC1) Interaktionspartnern

Zebrafish Ornithine Decarboxylase 1 (ODC1) Interaktionspartner

  1. molecular cloning of species-specific enzyme and its antizyme-mediated degradation

Human Ornithine Decarboxylase 1 (ODC1) Interaktionspartner

  1. Extracellular polyamines induced proliferation and cancer cell migration by inducing ODC and SSAT expression, and the Akt1-mediated pathway.

  2. Ornithine decarboxylase (ODC) plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as high-grade prostate intraepithelial neoplasia (HGPIN).

  3. Findings suggest that targeting ornithine decarboxylase 1 (ODC1) could be an attractive option for molecular therapy of hepatocellular carcinoma (HCC).

  4. Binding of RS1-Reg to ODC1 inhibits the enzymatic activity at low intracellular glucose, which is blunted at high intracellular glucose.

  5. mechanistic study of the molecular interactions between antizyme inhibitor and its interacting proteins CCND1 and ornithine decarboxylase

  6. We earlier presented evidence for a physical interaction between ODC and SPR and we showed that RNAi-mediated knockdown of SPR expression significantly reduced native ODC enzyme activity and impeded Neuroblastoma cell proliferation.

  7. Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ornithine decarboxylase levels, leading to an increase of the polyamine content.

  8. High ODC expression is associated with Medulloblastoma.

  9. Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN).

  10. Data suggest that down-regulation of ODC (using siRNA or pharmacologic inhibitor) in bone marrow-derived mesenchymal stem cells results in reduced intracellular polyamines (putrescine, spermidine, and spermine) and enhanced osteogenesis.

  11. tumor ornithine decarboxylase level heterogeneity increased with increasing tumor malignancy

  12. The results suggested that the ODC gene might act as a prognostic factor for breast cancer and it could be a promising therapeutic target.

  13. BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue

  14. Akt activation by ODC+COX-2 over-expression.

  15. Authors identified SPR as a novel regulator of ODC enzyme activity and, based on clinical evidence, present a model in which SPR drives ODC-mediated malignant progression in neuroblastoma.

  16. ODC overexpression suppresses the expression of tumstatin, which may provide fundamental evidence for the combination of anti-angiogenic therapy and conventional therapy for cancer treatment.

  17. The results of this study suggest that specific genetic variants in a subset of glutamatergic (GRIN2B) and polyaminergic (ODC1) neurosystem genes may be of importance in certain suicidal subjects.

  18. There are five conserved residues in ODC.

  19. Based on the investigation of the polyamine metabolite pathway, these data establish that the downstream metabolites of ornithine are increased, potentially implicating ornithine decarboxylase activity in AD pathology.

  20. Overexpression of antizyme (AZ), an ornithine decarboxylase (ODC) inhibitory protein, suppressed ERalpha expression, suggesting that ODC plays an important role in regulation of ERalpha expression.

Xenopus laevis Ornithine Decarboxylase 1 (ODC1) Interaktionspartner

  1. Translation of ODC is therefore integral to cytoplasmic maturation, protecting metaphase II oocytes from reactive oxygen species-induced apoptosis.

Mouse (Murine) Ornithine Decarboxylase 1 (ODC1) Interaktionspartner

  1. Findings indicated that ornithine decarboxylase (ODC1) was involved in attenuating the inflammatory response upon stimulation of macrophages, making it a potential therapeutic target for inflammatory diseases.

  2. We demonstrate that ornithine decarboxylase (ODC) regulates M1 activation during Helicobacter pylori and Citrobacter rodentium infection. Deletion of Odc in macrophages resulted in increased inflammation and decreased bacterial persistence in mouse models. The enhanced M1 response was due to alterations in histone modifications, resulting in changes in chromatin structure and up-regulated transcription.

  3. these data support the hypothesis that TTP plays a role in the post-transcriptional regulation of the ODC mRNA transcript.

  4. Ornithine decarboxylase (ODC) plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as high-grade prostate intraepithelial neoplasia (HGPIN).

  5. the Myc-ODC axis plays a critical role in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant

  6. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.

  7. Androgens act via the AR to upregulate Odc1 in skeletal muscle myoblasts, and Odc1 promotes myoblast proliferation and delays differentiation.

  8. the immunosuppression promoted by increased epidermal ODC is mediated by a reduction in cytokine levels, which suppresses dendritic cell migration and reduces immune cell infiltration to the site of hapten application

  9. HuR plays a causative role in ODC up-regulation during nonmelanoma skin cancer development by binding to and stabilizing the ODC transcript.

  10. Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation

  11. In B16-F1 cells HGF increased AP-1 activity and the mRNA expression of various AP-1 subunits. HGF-induced transcription of mouse ODC was largely due to triggering of AP-1 pathway.

  12. The preovulatory rise is required for progesterone secretion by the corpus luteum

  13. cell constituents required for mODC degradation are conserved between animals and fungi, and that both mammalian and fungal ODC are subject to proteasome-mediated proteolysis by ubiquitin-independent mechanisms

  14. gene expression regulation by testosterone in mouse kidney

  15. Proteasome initiates degradation of this native enzyme at the C terminus.

  16. The role of ODC in the Citrobacter rodentium model of colitis was studied. ODC was induced in the colon during the infection. Inhibition of ODC exacerbated the colitis.

  17. elevated ODC values found in the ovary of immature and adult mice play a relevant function in ovarian physiology

  18. de novo suprabasal induction of ODC activity in adult mouse skin activates keratinocytes and stimulates vascularization in the dermal layer in a manner similar to skin undergoing wound healing.

  19. c-Myc is an important mediator of macrophage activation and may contribute to the mucosal inflammatory response to pathogens such as H. pylori by its effect on ornithine decarboxylase

  20. Odc is a critical Myc transcription target that regulates checkpoints that guard against tumorigenesis and is an effective target for cancer chemoprevention.

Ornithine Decarboxylase 1 (ODC1) Protein Überblick

Protein Überblick

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.

Genbezeichner und Symbole assoziert mit ODC1

  • Ornithine decarboxylase 1 (Odc1)
  • ornithine decarboxylase 1 (odc1)
  • ornithine decarboxylase 1 (ODC1)
  • ornithine decarboxylase (odc)
  • diaminopimelate decarboxylase (RR_RS04895)
  • ornithine decarboxylase (ASA_RS06380)
  • Orn/DAP/Arg decarboxylase 2 domain-containing protein (odc)
  • Diaminopimelate decarboxylase (odc)
  • Ornithine decarboxylase (odc)
  • ornithine decarboxylase (LOC100232922)
  • ornithine decarboxylase 1 (Odc1)
  • ornithine decarboxylase 1 L homeolog (odc1.L)
  • ornithine decarboxylase, structural 1 (Odc1)
  • Ornithine decarboxylase (odc-1)
  • CG8721 Protein
  • CHUNP6922 Protein
  • DDBDRAFT_0204020 Protein
  • DDBDRAFT_0237755 Protein
  • DDB_0204020 Protein
  • DDB_0237755 Protein
  • Dmel\\CG8721 Protein
  • dodc1 Protein
  • fc54f04 Protein
  • fi06d08 Protein
  • Odc Protein
  • ODC1 Protein
  • odc1-a Protein
  • odc2 Protein
  • wu:fc54f04 Protein
  • wu:fi06d08 Protein
  • xODC1 Protein
  • xodc2 Protein

Bezeichner auf Proteinebene für ODC1

ornithine decarboxylase 1 , CG8721-PA , Odc1-PA , ornithine decarboxylase , group IV decarboxylase , Ornithine decarboxylase , Ornitine decarboxylase , ODC 1 , xODC1

35766 Drosophila melanogaster
114426 Danio rerio
448028 Xenopus (Silurana) tropicalis
459027 Pan troglodytes
553919 Lotus japonicus
695625 Macaca mulatta
2866337 Bartonella quintana str. Toulouse
3129917 Haloarcula marismortui ATCC 43049
4944153 Saccharopolyspora erythraea NRRL 2338
4995583 Aeromonas salmonicida subsp. salmonicida A449
5723008 Chlamydomonas reinhardtii
8622878 Dictyostelium discoideum AX4
9448557 Corynebacterium pseudotuberculosis FRC41
9700620 gamma proteobacterium HdN1
10843230 Corynebacterium ulcerans BR-AD22
100027936 Monodelphis domestica
100232922 Vitis vinifera
100303479 Saccoglossus kowalevskii
100404336 Callithrix jacchus
100435590 Pongo abelii
100463572 Ailuropoda melanoleuca
100567639 Anolis carolinensis
100581966 Nomascus leucogenys
414408 Sus scrofa
4953 Homo sapiens
24609 Rattus norvegicus
100717513 Cavia porcellus
281365 Bos taurus
421937 Gallus gallus
475666 Canis lupus familiaris
379859 Xenopus laevis
18263 Mus musculus
179079 Caenorhabditis elegans
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