One Cut Homeobox 1 Proteine (ONECUT1)

ONECUT1 encodes a member of the Cut homeobox family of transcription factors. Zusätzlich bieten wir Ihnen One Cut Homeobox 1 Antikörper (56) und One Cut Homeobox 1 Kits (23) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ONECUT1 15379 O08755
ONECUT1 25231 P70512
ONECUT1 3175 Q9UBC0
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,309.17
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ONECUT1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Rat (Rattus)

Human

Weitere Proteine zu One Cut Homeobox 1 (ONECUT1) Interaktionspartnern

Mouse (Murine) One Cut Homeobox 1 (ONECUT1) Interaktionspartner

  1. These results suggest that Oc1 and Pdx1 cooperate prior to their divergence, in pancreatic progenitors, to allow for proper differentiation and functional maturation of beta cells.

  2. Expression of motor neuron effector genes is maintained by transient enhancers bound by Isl1/Lhx3 in nascent motor neurons and Isl1/Onecut1 in maturing hypaxial motor neurons.

  3. Data show that growth hormone (GH)/lipopolysaccharides (LPS) co-treatment enhanced hepatocyte nuclear factor 6 (Hnf6) expression with corresponding attenuation of apoptosis in WT-derived hepatocytes, but not in KO hepatocytes.

  4. HNF6 binding was sex independent at a majority of binding sites, and HNF6 peaks were frequently associated with cobinding by multiple other liver transcription factors, consistent with HNF6 playing a global regulatory role in both male and female liver.

  5. with Lmx1a to promote ventral midbrain neural stem cells differentiation into dopamine neuron through Wnt1-Lmx1a pathway.

  6. Onecut1 and Onecut2 have roles in operating downstream of Pax6 to regulate horizontal cell development

  7. similar to Onecut1, Onecut2 is also necessary for the formation of normal numbers of horizontal cells in the developing retina.

  8. identified downstream genes of Oc1 and Oc2 that shows that the onecut factors suppress the production of the late cell type, rods, indicating that the two factors contribute to the competence of retinal progenitor cells for early retinal cell fates

  9. Sex-dependent growth hormone secretion patterns affect the expression of HNF6 in liver.

  10. Liver cell plasticity is competent for regeneration of intrahepatic bile duct independent of Notch signaling via Rbpj and Hnf6.

  11. in Hnf6-/- mice, the organization of Purkinje cells became abnormal during a second phase of their development.

  12. Insight on the role of HNF6 in pancreatic cancer development could lead to its use as a biomarker for early detection and prognosis.

  13. Findings suggest that Onecut1 suppresses MafA gene expression through the Foxa2-binding site.

  14. Let-7b, miR-495, and their targets constitute a gene network that is required to establish and maintain pancreatic acinar cell differentiation. Let-7b and miR-495 repress HNF6 and are expressed in developing acini.

  15. this study showed that Onecut1 is essential for horizontal cell genesis and retinal integrity in mice.

  16. Onecut1 suppresses rod photoreceptor genesis.

  17. HNF-6 controls in spinal motor neurons a genetic program that coordinates the formation of hindlimb neuromuscular junctions

  18. HNF6 and Sox9 are new biomarkers of pancreatic acinar-to-ductal metaplasia and constitute candidate targets for preventive treatment in cases when acinar-to-ductal metaplasia may lead to cancer.

  19. Onecut1 and Onecut2 are expressed in both developing and mature horizontal cells of the retina.

  20. HNF-6 and Notch signaling interact in vivo to control expression of downstream mediators essential to the normal development of the intrahepatic biliary system.

Human One Cut Homeobox 1 (ONECUT1) Interaktionspartner

  1. Reduced HNF6 expression is associated with metastasis of cholangiocarcinoma.

  2. HNF6 is a novel host factor that can restrict hepatitis B virus replication via both transcriptional and posttranscriptional mechanisms.

  3. The negative correlation between HNF6 expression and pancreatic cancer progression suggests that HNF6 maintains pancreatic epithelial homeostasis, and that its loss contributes to the progression from intraepithelial neoplasms to ductal adenocarcinoma.

  4. HNF6 plays an important role in the gene regulation of CYP3A4 during development from the fetal period to the postnatal period.

  5. HNF6 inhibits EMT, cell migration, and invasive growth through a mechanism involving the transcriptional activation of p53.

  6. Mutations at the -5/-6 site of the F9 promotor account for the majority of hemophilia B Leyden cases and disrupt the binding of ONECUT1 and ONECUT2.

  7. HNF6 and Sox9 are new biomarkers of pancreatic acinar-to-ductal metaplasia and constitute candidate targets for preventive treatment in cases when acinar-to-ductal metaplasia may lead to cancer.

  8. Hepatocyte nuclear factor 6 is one of the liver-enriched transcription factors, it utilizes the bipartite onecut-homeodomain sequence to localize to the nuclear compartment and bind specific DNA sequences of numerous target gene promoters

  9. functional knockdown of FOXA2 recovered HNF6 activity and inhibited growth of tumor-cells and may possibly represent a novel therapeutic target in primary and secondary liver malignancies

  10. HNF6 has a role as a coactivator protein to potentiate the transcriptional activity of another liver factor, FoxA2

  11. These findings define a precursor cellular stage of the embryonic pancreas and place Hnf1beta in a genetic hierarchy that regulates the generation of pancreatic endocrine cells.

  12. identifed systematically the genes occupied by the transcriptional regulators HNF1alpha, HNF4alpha, and HNF6, together with RNA polymerase II in human liver and pancreatic islets

  13. HNF6 protein stability is controlled by CBP acetylation

  14. A comparision of gene expression patterns induced by hepatic nuclear factors, HNF6, HNF4alpha and HNF1beta, in a pancreatic beta-cell line.

  15. HNF6 DNA binding is selectively abrogated through lack of post-translational modification and interaction with FOXA2. Targeting of FOXA2 and HNF6 may therefore enable mechanism-based therapy for colorectal liver metastases

  16. ONECUT1 expression is lost in pancreatic cancer cells, suggesting a tumor suppressor function in this malignancy.

  17. Results suggest that HNF-6 is a novel target of small heterodimer partner in the regulation of gluconeogenesis.

Zebrafish One Cut Homeobox 1 (ONECUT1) Interaktionspartner

  1. findings identify vps33b is a novel downstream target gene of the hnf6/vhnf1 pathway that regulates bile duct development in zebrafish

One Cut Homeobox 1 (ONECUT1) Protein Überblick

Protein Überblick

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit One Cut Homeobox 1 Proteine (ONECUT1)

  • one cut domain, family member 1 (Onecut1)
  • one cut homeobox 1 (Onecut1)
  • one cut homeobox 1 (ONECUT1)
  • one cut homeobox 1 (onecut1)
  • D9Ertd423e Protein
  • Hfh12 Protein
  • HNF-6 Protein
  • HNF-6a Protein
  • HNF6 Protein
  • HNF6A Protein
  • Hnf6b Protein
  • OC-1 Protein
  • oc1 Protein
  • onecut1l Protein
  • zgc:65904 Protein
  • zgc:77450 Protein

Bezeichner auf Proteinebene für One Cut Homeobox 1 Proteine (ONECUT1)

HNF-3/forkhead homolog 12 , hepatic nuclear factor 6 , hepatocyte nuclear factor 6 , one cut homeobox 1 , HNF-6 , one cut domain family member 1 , one cut domain, family member 1 , hepatocyte nuclear factor 6, alpha , hepatocyte nuclear factor 6 alpha , hnf-6 , hnf6 , one cut domain, family member 1, like

GENE ID SPEZIES
15379 Mus musculus
25231 Rattus norvegicus
3175 Homo sapiens
503584 Bos taurus
393545 Danio rerio
487558 Canis lupus familiaris
100723740 Cavia porcellus
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