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Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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NPAT links E2F to the activation of S-phase-specific histone gene transcription.
Data indicate that the CDK2/cyclin E/p220(NPAT)/HINFP/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis.
Cpn10 has a role in the spatial regulation of NPAT signaling
The conserved C-terminal domain shared by FLASH, YARP, and Mute recognizes the C-terminal sequence of NPAT orthologues, thus acting as a signal targeting proteins to histone locus bodies.
Genetic variants of NPAT-ATM and AURKA are associated with an individual early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy
NPAT is thus far the first gene implicated in nodular lymphocyte predominant Hodgkin lymphoma predisposition.
NPAT is essential for histone mRNA 3' end processing and recruits CDK9 to replication-dependent histone genes.
Results characterize the functional signals required for NPAT localization to the cell nucleus.
the ability of p220 to promote S phase is independent of its ability to promote histone H4 transcription and p220 may link cyclin E/Cdk2 to multiple independent downstream functions
OCA-S, the multicomponent Oct-1 coactivator, intercts with NPAT.
p220 is an essential downstream component of the cyclin E/Cdk2 signaling pathway and functions to coordinate multiple elements of the G1/S transition.
NPAT, together with CUL5 and PPP2R1B, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL.
NPAT recruits the TRRAP-Tip60 complex to histone gene promoters to coordinate the transcriptional activation of multiple histone genes during the G(1)/S-phase transition
HiNF-P/P220NPAT regulates expression of nonhistone targets that influence competency for cell cycle progression.
Only the number of FLASH/NPAT histone gene locus bodies correlates with ploidy and only these organelles appear to be regulated during the cell cycle.
Results suggest that cyclin-dependent kinase inhibitors selectively control stimulation of the histone H4 gene promoter by the p220(NPAT)/HiNF-P complex.
The subnuclear organization of histone gene regulatory proteins and 3' end processing factors (NPAT/LSM10) of normal somatic and embryonic stem cells is compromised in selected human cancer cell types.
Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells.
Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes (By similarity).
, nuclear protein in the AT region
, nuclear protein, ataxia-telangiectasia locus
, protein NPAT-like
, nuclear protein of the ATM locus
, nuclear protein of the ataxia telangiectasia mutated locus