Neuroglobin Proteine (NGB)

NGB encodes an oxygen-binding protein that is distantly related to members of the globin gene family. Zusätzlich bieten wir Ihnen Neuroglobin Antikörper (97) und Neuroglobin Kits (66) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NGB 58157 Q9NPG2
NGB 64242 Q9ER97
NGB 85382 Q99JA8
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Showing 10 out of 22 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$814.00
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Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Anmelden zum Anzeigen 11 Days
$411.40
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Schimpanse His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,333.83
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Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,333.83
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Hefe Rhesusaffen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,333.83
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,333.83
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,333.83
Details

NGB Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , , ,
Mouse (Murine)
,
Rat (Rattus) ,

Am meisten referenzierte Neuroglobin Proteine

  1. Human Neuroglobin Protein expressed in Wheat germ - ABIN1312525 : Powers: p53-mediated apoptosis, neuroglobin overexpression, and globin deposits in a patient with hereditary ferritinopathy. in Journal of neuropathology and experimental neurology 2006 (PubMed)

Weitere Proteine zu Neuroglobin (NGB) Interaktionspartnern

Human Neuroglobin (NGB) Interaktionspartner

  1. Neuroglobin functions as an important modulator of the Wnt/beta-Catenin and NFkappaB signaling pathway through direct interaction with Dishevelled-1.

  2. This study demonstrated that serum NGB levels were significantly associated with 6-month unfavorable outcomes, indicating that Ngb can play a role in predicting 6-month unfavorable outcomes.

  3. Results show that the expression of NGB in glioma is grade related and is negatively regulated at the transcriptional level by PPARgamma suggesting an important role of NGB in glioma progression.

  4. The authors demonstrate that Glu53, Glu60, and Glu118 of human Ngb are crucial for both the neuroprotective activity and interaction with Gi. Moreover, they show that Lys46, Lys70, Arg208, Lys209, and Lys210 residues of Gi are important for binding to human Ngb.

  5. Ngb-H64Q-CCC binds CO about 500 times more strongly than hemoglobin, which could be useful in detecting and eliminating carbon monoxide poisoning

  6. these results highlight the involvement of ERa activation and of E2/ERa-dependent NGB upregulation in the insensitivity of MCF-7 to paclitaxel. These novel findings could have important implications in the development of targeted therapeutics for overcoming paclitaxel insensitivity in ERa-positive human breast cancer

  7. Knockdown of GATA-2 caused NGB expression to drop dramatically, indicating GATA-2 as an essential transcription factor for the activation of NGB expression via binding to a novel distal regulatory element of NGB.

  8. analysis of how the interaction of hydrogen sulfide with human neuroglobin is muted by a distal ligand

  9. NO oxidation kinetics at physiological NO concentrations. The use of a polarized electrode to efficiently interconvert the ferric (Fe(3+)) and ferrous (Fe(2+)) forms of an immobilized NGB showed that the disulfide bridge both defines the kinetics of NO dioxygenase activity and regulates appearance of the free ferrous deoxy-NGB, which is the redox active form of the protein in contrast to oxy-NGB.

  10. Taken together, this work support the first evidence that Ngb can be potentially used as a promising biomarker and target for novel treatment of human glioma

  11. The cochlear nuclei and superior olivary complex (SOC) also express considerable amounts of Ngb. Within the human SOC, many medial superior olive neurons, and scattered neurons in the LSO, were Ngb-immunoreactive

  12. Study characterized the presence of Ngb in the human cochlea

  13. Data show that the mean peak serum neuroglobin and Nogo-A concentrations were both significantly higher in patients with an unfavorable outcome at 6 months after traumatic brain injury (TBI).

  14. Findings suggest a control model for neuroglobin's anti-apoptotic activity under physiological conditions. While in normoxic conditions, its activity is maintained at low level, an immediate transition to an hypoxic situation increases it drastically.

  15. The review summarizes the recent experimental findings, mainly focusing on the mechanisms of Ngb's protection and induction during ischemic/hypoxic conditions and it roles in astrocytes, tumors, as well as in neurite outgrowth. [review]

  16. Neuroglobin player role in estrogen receptor alpha-positive cancer cell viability.

  17. a mechanism for redox control of human Ngb (hNgb) activity

  18. 17beta-estradiol-induced NGB up-regulation could act as an oxidative stress sensor, which does not oppose to the pro-apoptotic 17beta-estradiol effect in ER beta-containing colon cancer cells unless a rise of oxidative stress occurs.

  19. first X-ray structure of wild-type human neuroglobin is reported at 1.74 A resolution

  20. Glu60 of human Ngb is a crucial residue for its GDI and neuroprotective activities

Mouse (Murine) Neuroglobin (NGB) Interaktionspartner

  1. This is the first report demonstrating a similar pattern of Ngb expression during disease progression in the brains of R6/2 mice.

  2. NGB proved to act cytoprotectively during MI in the acute setting while this effect was less pronounced in the atherosclerosis model.

  3. Study showed that in Neuroglobin (Ngb) knockout mice, distortion-product otoacoustic emissions thresholds were moderately augmented in the range of 5-18kHz. Results suggest that the lack of NgB, results in only marginal deficits in hearing ability.

  4. Ngb-H64Q-CCC binds CO about 500 times more strongly than hemoglobin, which could be useful in detecting and eliminating carbon monoxide poisoning

  5. Ngb can bind to mitochondrial complex III subunit Cyc1, leading to suppression of oxygen-glucose deprivation -mediated complex III activity.

  6. Reduction of Ngb expression in mouse retina after optic nerve injury.Ngb role in neuroregeneration in mice after optic nerve injury.

  7. Findings provide evidence for the loss of globin-linked neuroprotection to be linked to Alzheimer's disease angiopathogenesis, while raising the possibility of REST/ NRSF being an upstream regulator.

  8. Ngb expression is limited to the subpopulation of type I spiral ganglion cells, those which innervate inner hair cells, while the subpopulation of type II spiral ganglion cells which innervate the outer hair cells do not express Ngb. The cochlear nuclei and superior olivary complex (SOC) also express considerable amounts of Ngb.

  9. Ngb functions as a metabolic regulator and enhances cellular anabolism through the inhibition of AMPK signaling.

  10. Data show that the neuroglobin (Ngb) protein was downregulated in the retinal ganglion cells after optic nerve injury.

  11. Overexpression of neuroglobin reduced sensorimotor deficits following TBI. An endogenous increase in neuroglobin expression occurs during the subacute period. Increasing neuroglobin expression during the acute period after TBI may improve recovery.

  12. reflect lesser perturbations produced by acute inhalation of combustion smoke in the Ngb overexpressing mouse, suggesting that Ngb mitigates mitochondrial dysfunction and neurotoxicity and raises the threshold of smoke inhalation-induced brain injury

  13. A critical role for neuroglobin is demonstrated via its differential interaction with phosphatase and tensin homolog (PTEN) and Akt during neurite induction.

  14. Neuroglobin overexpression resulted in a significant reduction in infarct volume 24 hours after brain ischemia.

  15. Ngb overexpression can inhibit oxygen-glucose deprivation-induced mitochondria permeability transition opening in primary cultured mouse cortical

  16. CREB may also mediate transcriptional regulation of neuroglobin gene.

  17. Ngb deficiency neither affected the level of Melanopsin and Tyrosine Hydroxylase proteins nor the intactness of PACAP-positive retinohypothalamic projections in the suprachiasmatic nucleus.

  18. This study demonistrated that Ngb over-expression reduced traumatic lesion volume.

  19. mitochondria distribution of Ngb is clearly associated with and may contribute to Ngb's neuroprotection.

  20. VEGF stimulated Ngb expression in a VEGFR2/Flk1 receptor-dependent manner, whereas Ngb overexpression suppressed expression of VEGF.

Pig (Porcine) Neuroglobin (NGB) Interaktionspartner

  1. Constitutive expression levels of neuroglobin in neonatal brain cells may explain mild neuronal injury after 60 min. of deep hypothermic circulatory arrest.

Zebrafish Neuroglobin (NGB) Interaktionspartner

  1. The zebrafish Neuroglobin can catalyze the reduction of nitrite to nitric oxide with a broad range of reaction rate constants.

  2. Data show that the neuroglobin (Ngb) protein was upregulated in the amacrine cells after optic nerve injury.

  3. Chimeric Myoglobin has a cell-membrane-penetrating activity similar to zebrafish Ngb.

  4. Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin-like function of this protein in facilitated oxygen diffusion

  5. both zebrafish and chimeric ZHHH Ngb can penetrate cell membranes in the absence of Chariot

Rabbit Neuroglobin (NGB) Interaktionspartner

  1. Ngb overexpression may have potential therapeutic benefits for both reducing secondary damages and improving the outcomes after traumatic spinal cord injury

Neuroglobin (NGB) Protein Überblick

Protein Überblick

This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions.

Genbezeichner und Symbole assoziert mit Neuroglobin Proteine (NGB)

  • neuroglobin (NGB)
  • neuroglobin (Ngb)
  • neuroglobin (ngb)
  • neuroglobin L homeolog (ngb.L)
  • ngb Protein

Bezeichner auf Proteinebene für Neuroglobin Proteine (NGB)

neuroglobin

GENE ID SPEZIES
58157 Homo sapiens
64242 Mus musculus
85382 Rattus norvegicus
414438 Sus scrofa
414920 Bos taurus
428896 Gallus gallus
442944 Canis lupus familiaris
443260 Ovis aries
467518 Pan troglodytes
594898 Xenopus (Silurana) tropicalis
641331 Macaca mulatta
641332 Monodelphis domestica
734191 Xenopus laevis
100000711 Danio rerio
100008868 Oryctolagus cuniculus
100379566 Cavia porcellus
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