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NGB encodes an oxygen-binding protein that is distantly related to members of the globin gene family. Zusätzlich bieten wir Ihnen Neuroglobin Antikörper (95) und Neuroglobin Kits (66) und viele weitere Produktgruppen zu diesem Protein an.
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Human Neuroglobin Protein expressed in Wheat germ - ABIN1312525
Powers: p53-mediated apoptosis, neuroglobin overexpression, and globin deposits in a patient with hereditary ferritinopathy. in Journal of neuropathology and experimental neurology 2006
Neuroglobin functions as an important modulator of the Wnt (zeige WNT2 Proteine)/beta-Catenin (zeige CTNNB1 Proteine) and NFkappaB (zeige NFKB1 Proteine) signaling pathway through direct interaction with Dishevelled-1 (zeige DVL1 Proteine).
This study demonstrated that serum NGB (zeige GTPBP4 Proteine) levels were significantly associated with 6-month unfavorable outcomes, indicating that Ngb (zeige GTPBP4 Proteine) can play a role in predicting 6-month unfavorable outcomes.
Results show that the expression of NGB (zeige GTPBP4 Proteine) in glioma is grade related and is negatively regulated at the transcriptional level by PPARgamma (zeige PPARG Proteine) suggesting an important role of NGB (zeige GTPBP4 Proteine) in glioma progression.
The authors demonstrate that Glu53, Glu60, and Glu118 of human Ngb (zeige GTPBP4 Proteine) are crucial for both the neuroprotective activity and interaction with Gi. Moreover, they show that Lys46, Lys70, Arg208, Lys209, and Lys210 residues of Gi are important for binding to human Ngb (zeige GTPBP4 Proteine).
Ngb-H64Q-CCC binds CO about 500 times more strongly than hemoglobin, which could be useful in detecting and eliminating carbon monoxide poisoning
these results highlight the involvement of ERa activation and of E2/ERa-dependent NGB (zeige GTPBP4 Proteine) upregulation in the insensitivity of MCF-7 to paclitaxel. These novel findings could have important implications in the development of targeted therapeutics for overcoming paclitaxel insensitivity in ERa-positive human breast cancer
Knockdown of GATA-2 (zeige GATA2 Proteine) caused NGB (zeige GTPBP4 Proteine) expression to drop dramatically, indicating GATA-2 (zeige GATA2 Proteine) as an essential transcription factor for the activation of NGB (zeige GTPBP4 Proteine) expression via binding to a novel distal regulatory element of NGB (zeige GTPBP4 Proteine).
analysis of how the interaction of hydrogen sulfide (zeige SQRDL Proteine) with human neuroglobin is muted (zeige MUTED Proteine) by a distal ligand
NO oxidation kinetics at physiological NO concentrations. The use of a polarized electrode to efficiently interconvert the ferric (Fe(3+)) and ferrous (Fe(2+)) forms of an immobilized NGB (zeige GTPBP4 Proteine) showed that the disulfide bridge both defines the kinetics of NO dioxygenase activity and regulates appearance of the free ferrous deoxy-NGB (zeige GTPBP4 Proteine), which is the redox active form of the protein in contrast to oxy (zeige GCG Proteine)-NGB (zeige GTPBP4 Proteine).
Taken together, this work support the first evidence that Ngb (zeige GTPBP4 Proteine) can be potentially used as a promising biomarker and target for novel treatment of human glioma
This is the first report demonstrating a similar pattern of Ngb expression during disease progression in the brains of R6/2 mice.
NGB proved to act cytoprotectively during MI in the acute setting while this effect was less pronounced in the atherosclerosis model.
Study showed that in Neuroglobin (Ngb) knockout mice, distortion-product otoacoustic emissions thresholds were moderately augmented in the range of 5-18kHz. Results suggest that the lack of NgB, results in only marginal deficits in hearing ability.
Ngb can bind to mitochondrial complex III subunit Cyc1 (zeige CYC1 Proteine), leading to suppression of oxygen-glucose deprivation -mediated complex III activity.
Reduction of Ngb expression in mouse retina after optic nerve injury.Ngb role in neuroregeneration in mice after optic nerve injury.
Findings provide evidence for the loss of globin-linked neuroprotection to be linked to Alzheimer's disease angiopathogenesis, while raising the possibility of REST/ NRSF (zeige REST Proteine) being an upstream regulator.
Ngb expression is limited to the subpopulation of type I spiral ganglion cells, those which innervate inner hair cells, while the subpopulation of type II spiral ganglion cells which innervate the outer hair cells do not express Ngb. The cochlear nuclei and superior olivary complex (SOC (zeige UBXN11 Proteine)) also express considerable amounts of Ngb.
Ngb functions as a metabolic regulator and enhances cellular anabolism through the inhibition of AMPK (zeige PRKAA1 Proteine) signaling.
Data show that the neuroglobin (Ngb) protein was downregulated in the retinal ganglion cells after optic nerve injury.
Constitutive expression levels of neuroglobin in neonatal brain cells may explain mild neuronal injury after 60 min. of deep hypothermic circulatory arrest.
The zebrafish Neuroglobin can catalyze the reduction of nitrite to nitric oxide with a broad range of reaction rate constants.
Data show that the neuroglobin (Ngb) protein was upregulated in the amacrine cells after optic nerve injury.
Chimeric Myoglobin (zeige MB Proteine) has a cell-membrane-penetrating activity similar to zebrafish Ngb.
Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin (zeige MB Proteine)-like function of this protein in facilitated oxygen diffusion
both zebrafish and chimeric ZHHH Ngb can penetrate cell membranes in the absence of Chariot
Ngb overexpression may have potential therapeutic benefits for both reducing secondary damages and improving the outcomes after traumatic spinal cord injury
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions.