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Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). Zusätzlich bieten wir Ihnen NPR1 Antikörper (88) und NPR1 Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.
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Data suggest that signaling via ANP (zeige NPPA ELISA Kits)/ANPR (atrial natriuretic factor/ANP (zeige NPPA ELISA Kits) receptor (zeige PPP5C ELISA Kits)) in vascular endothelial cells activates PAK4 (p21-activated kinase 4 (zeige PAK4 ELISA Kits)) and CCM2 (cerebral cavernous malformation 2 (zeige CCM2 ELISA Kits) protein), resulting in phosphorylation of MLC (myosin light chain), cytoskeletal reorganization, and cell spreading; kinase homology domain of ANPRA (guanylyl cyclase-A) activates downstream targets of ANP (zeige NPPA ELISA Kits)/ANPR signaling.
After ligand binding, NPRA is rapidly internalized and trafficked from the cell surface into endosomes, Res and lysosomes, with concurrent generation of intracellular cyclic GMP (zeige NT5C2 ELISA Kits) in HEK (zeige EPHA3 ELISA Kits)-293 cells.
Data suggest up-regulation of NPRA in skeletal muscle (SM) correlates with whole-body insulin sensitiv (zeige INS ELISA Kits)ity; NPRA is down-regulated in SM in obese subjects compared to normal controls; NPRA in SM is up-regulated in response to diet-induced weight loss.
In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation
NPRA was detected in E11.5 cardiac progenitor cells.
Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A/-B activator.
High NPR1 expression is associated with esophageal squamous cell carcinomas.
Molecular dynamics analysis indicated decreases in the values of Van (zeige TNIP1 ELISA Kits) der (zeige GDF3 ELISA Kits) Waals, electrostatic energy and potential energy of NPRB (zeige NPR2 ELISA Kits)/Vasonatrin peptide compared to NPRA/Vasonatrin peptide.
ACNP stimulated both human natriuretic peptide receptors (NPRs), NPRA and NPRB (zeige NPR2 ELISA Kits), as potent as their native ligands in receptor transfected cells.
human ventricular cardiomyocytes express low levels of GC-A and GC-A in cardiomyocytes from failing human hearts is refractory to ANP (zeige NPPA ELISA Kits) stimulation.
KLF10 and atrial natriuretic peptide (zeige NPPA ELISA Kits)/NPRA in exerting influences on chronic pulmonary disease pathogenesis
Treatment of the haplotype Npr1(+/-) mice with histone deacetylase (zeige HDAC1 ELISA Kits) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (zeige HDAC1 ELISA Kits)/2, NF-kappaB (zeige NFKB1 ELISA Kits) (p65 (zeige NFkBP65 ELISA Kits)), and STAT1 (zeige STAT1 ELISA Kits).
Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.
The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis.
Conclude that postnatal cardiac hyperplasia in mice with global GC-A (zeige GUCA1A ELISA Kits) inactivation is provoked by systemic alterations rather than direct regulation of cardiac myocyte proliferation.
Data (including data from studies in knockout mice) suggest expression of ANP (zeige NPPA ELISA Kits)/BNP/GC-A (zeige GUCA1A ELISA Kits) (atrial natriuretic peptide (zeige NPPA ELISA Kits), brain natriuretic peptide (zeige BNP ELISA Kits), and guanylyl cyclase-A) is important in embryonic neovascularization and organogenesis.
Suggest that the FQQI motif is essential for the internalization and subcellular trafficking of NPRA during the hormone signaling process in intact mesangial cells.
Data suggest activation of skeletal muscle (SM) Npra is important for maintenance of long-term insulin (zeige INS ELISA Kits) sensitivity; up-regulation of Npra signal transduction in SM (that was reduced by obesity) prevents glucose intolerance and diabetes type 2.
these findings define a novel epigenetic regulatory mechanism that governs Npr1 gene transcription.
Npr1 represses the expression of cardiac proinflammatory mediators, hypertrophic markers, and NF-kappaB/AP-1-mediated mechanisms, which seem to be associated in an Npr1 gene-dose-dependent manner
We identified a rice mutant in the Kitaake genetic background with a frameshift mutation in crk10; this mutant also displays a compromised immune response highlighting the important role of crk10. We also show that elevated levels of NH1 expression lead to enhanced CRK10 expression and that the rice TGA2.1 protein binds to the CRK10 promoter.
Green tissue-specific expression of Arabidopsis thaliana NPR1 is an effective strategy for controlling the sheath blight pathogen (Rhizoctonia solani) in rice. The present work in rice can be extended to other crop plants severely damaged by the pathogen.
The results revealed a tight correlation between sequential salicylic acid (SA) and sic acid (ABA) signaling and dynamic changes in NPR1 protein levels and NPR1-dependent transcription in plant immune responses.
Crosstalk between nitric oxide and glutathione is integral to the NPR1-dependent defense signaling pathway.
The authors show that sumoylation of NPR1 by SUMO3 (zeige SUMO3 ELISA Kits) activates defense gene expression by switching NPR1's association with the WRKY transcription repressors to TGA (zeige TBX1 ELISA Kits) transcription activators.
Altogether, our results indicate that AR156 can induce SAR by the SA-signaling pathways in an NPR1-dependent manner and involves multiple PTI components.
NPR1-dependent salicylic acid signaling is not involved in the elevated carbon dioxide-induced heat shock tolerance.
NPR1-dependent salicylic acid (SA) signalling is central to the salt and oxidative stress tolerance in Arabidopsis.
MPK6-mediated WRKY6 and Trx h5 transcriptional activation co-regulated the expression of the NPR1 gene and the monomerization of NPR1 protein, allowing it to enter the nucleus, thereby promoting salicylic acid-induced leaf senescence.
AtNPR1, AtGA2, and AtPR-5, encoding specific components involved in salicylic acid regulation, synthesis, and signaling, are overexpressed in soybean roots, resistance to soybean cyst nematode is enhanced.
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994
, atrial natriuretic peptide receptor 1
, atrial natriuretic peptide receptor type A
, atrionatriuretic peptide receptor A
, guanylate cyclase A
, natriuretic peptide A type receptor
, natriuretic peptide receptor A
, atrial natriuretic peptide A-type receptor
, atrial natriuretic peptide receptor A
, natriuretic peptide receptor 1
, aatriuretic peptide receptor A
, guanylyl cyclase beta 1, soluable
, natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
, Nppa receptor
, guanylyl cyclase-A