NUAK Family, SNF1-Like Kinase, 2 Proteine (NUAK2)

Stress-activated kinase involved in tolerance to glucose starvation. Zusätzlich bieten wir Ihnen NUAK Family, SNF1-Like Kinase, 2 Antikörper (78) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NUAK2 81788 Q9H093
NUAK2 74137 Q8BZN4
Ratte NUAK2 NUAK2 289419 Q66HE5
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Showing 6 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Insektenzellen Human His-GST 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$1,502.67
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Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$363.67
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Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
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NUAK2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu NUAK Family, SNF1-Like Kinase, 2 (NUAK2) Interaktionspartnern

Human NUAK Family, SNF1-Like Kinase, 2 (NUAK2) Interaktionspartner

  1. Data (including data from studies in knockout and transgenic mice) suggest that NUAK2/SNARK is involved in both adipose inflammation and energy metabolism in adipocytes; additionally, genome-wide association studies suggest that 2 SNPs in NUAK2/SNARK (rs4682880, rs4682676) are associated with obesity in women.

  2. miR143 inhibited the proliferation, migration and invasion of the glioblastoma cells by degrading NUAK2 in glioblastoma.

  3. Sucrose non-fermenting AMPK related kinase/Pentraxin 3 combined role in immunometabolic signaling and DNA damage response is proposed to accelerate cardiovascular complications in systemic lupus erythematosus patients

  4. NUAK2 silencing and inactivation of the PI3K pathway efficiently controlled CDK2 expression, whereas CDK2 inactivation specifically abrogated the growth of NUAK2-amplified and PTEN-deficient melanoma cells.

  5. The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-beta signaling.

  6. Activation of AMP-activated protein kinase protects the integrity of the blood-brain barrier by suppressing the induction of NADPH oxidase-derived superoxide anions.

  7. Considers possible roles of NUAK2 in tumorigenesis in general and suggest that NUAK2 has pivotal roles in acral melanomagenesis.

  8. MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP (myosin phosphatase Rho-interacting protein) and the inducible kinase NUAK2

  9. This study further supports the importance of NUAK2 in cancer development and tumor progression, while AMPK has antioncogenic properties.

  10. Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.

  11. SNARK is an NF-kappaB-regulated anti-apoptotic gene that contributes to the tumor-promoting activity of CD95 in apoptosis-resistant tumor cells

  12. These data suggests different phosphorylation and regulation of MYPT1 activity by NUAK2.

  13. EBV LMP1 upregulated the expression of SNARK; SNARK expression increased drug resistance in response to doxorubicin increased of cancer cell survival

  14. The nuclear localizing SNARK altered transcriptome profiles and a considerable part of these alterations were canceled by the mutation of NLS, suggesting the ability of SNARK to modulate gene expression dependent on its nuclear localization.

  15. Skeletal muscle SNARK expression is increased in human obesity, and in response to metabolic stressors, but not type 2 diabetes. Partial SNARK depletion failed to modify either glucose or lipid metabolism.

  16. This study describes the cloning and characterization of the rat SNARK homolog, mapping of the human SNARK gene to 1q32, and a potential functional role as mediator of the cellular response to metabolic stress.

Mouse (Murine) NUAK Family, SNF1-Like Kinase, 2 (NUAK2) Interaktionspartner

  1. Using liver cancer as a model, NUAK2 was identified as an essential mediator of YAP-driven hepatomegaly and tumorigenesis in vivo.

  2. Data (including data from studies in knockout and transgenic mice) suggest that Nuak2/Snark is involved in both adipose inflammation and energy metabolism in white/brown adipocytes; Nuak2/Snark appears to regulate thermogenesis in brown adipocytes.

  3. These findings reveal a critical role for SNARK in myocyte survival and the maintenance of muscle mass with age.

  4. NUAK1 and NUAK2 complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.

  5. Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.

  6. Obesity was a risk factor for colorectal tumorigenesis in Snark(+/-) mice model.

NUAK Family, SNF1-Like Kinase, 2 (NUAK2) Protein Überblick

Protein Überblick

Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity).

Genbezeichner und Symbole assoziert mit NUAK2

  • NUAK family kinase 2 (NUAK2)
  • NUAK family, SNF1-like kinase, 2 (Nuak2)
  • NUAK family kinase 2 (Nuak2)
  • 1200013b22rik Protein
  • mKIAA0537 Protein
  • Omphk2 Protein
  • Snark Protein
  • UV126 Protein

Bezeichner auf Proteinebene für NUAK2

NUAK family SNF1-like kinase 2 , SNF1/AMP activated protein kinase , SNF1/AMP kinase-related kinase , omphalocele kinase 2 , SNF1/AMP-activated protein kinase

GENE ID SPEZIES
81788 Homo sapiens
74137 Mus musculus
488570 Canis lupus familiaris
518632 Bos taurus
289419 Rattus norvegicus
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