NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 Proteine (NPC1L1)

The protein encoded by NPC1L1 is a multi-pass membrane protein. Zusätzlich bieten wir Ihnen NPC1L1 Antikörper (56) und NPC1L1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NPC1L1 237636  
Ratte NPC1L1 NPC1L1 432367 Q6T3U3
NPC1L1 29881 Q9UHC9
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 15 bis 17 Tage
$1,201.11
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NPC1L1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)
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Human ,
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Weitere Proteine zu NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) Interaktionspartnern

Pig (Porcine) NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) Interaktionspartner

  1. We therefore propose that cholesterol is absorbed by NPC1L1 acting as a membrane transporter and that NPC1L1 is internalized to an endosomal compartment to reduce the absorption of cholesterol.

Mouse (Murine) NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) Interaktionspartner

  1. The present study demonstrated that OPN deficiency reduced intestinal absorption of cholesterol by suppressing the expression of NPC1L1, thus protecting mice from cholesterol gallstone formation.

  2. Decreased mRNA levels of HNF4alpha and SREBP2 in mice could be involved in the reduction in NPC1L1 expression.

  3. NPC1L1 knockout protects against colitis-associated tumorigenesis.

  4. demonstrate that Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter, plays a central role in intestinal VK uptake and modulates the anticoagulant effect of warfarin. In

  5. NPC1L1 may suppress gluconeogenesis by inhibition of FoxO1 pathways.

  6. DNA methylation in the promoter region of the NPC1L1 gene appears to be a major mechanism underlying differential expression of NPC1L1 along the length of the gastrointestinal tract.

  7. cholesterol and tocopherol uptakes share common pathways in cell culture models, but display different in vivo absorption patterns associated with distinct contributions of SR-BI and NPC1L1

  8. The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1.

  9. Glucose appears to directly modulate NPC1L1 expression via transcriptional mechanisms and the involvement of phosphatase-dependent pathways.

  10. hepatitis c virus entry factor

  11. the mechanism of cholesterol sensing by NPC1L1 and proposes a mechanism for selective cholesterol absorption

  12. Cdc42 controls the cholesterol-regulated transport and localization of NPC1L1, and plays a role in cholesterol absorption.

  13. These findings demonstrated a direct role of hepatic NPC1L1 in regulating biliary cholesterol excretion and hepatic/blood cholesterol levels, and unequivocally established hepatic NPC1L1 as a target of ezetimibe.

  14. The results of this study indicated a general presynaptic functional impairment in the NPC1(-/-) neurons and such defects were not dependent of glial cells.

  15. flotillins have a role in NPC1L1-mediated cholesterol uptake and NPC1L1-flotillins-postive cholesterol-enriched membrane microdomains are involved in the mechanism for efficient cholesterol absorption

  16. NBD-cholesterol absorption proceeds through an NPC1L1-independent and ezetimibe-insensitive sterol absorption mechanism.

  17. increasing dietary cholesterol restores diet-induced weight gain in mice deficient in NPC1L1-dependent cholesterol absorption.

  18. NPC1L1 deficiency in mice prevents high-fat diet-induced fatty liver by reducing hepatic lipogenesis

  19. expression is enriched in the small intestine and is in the brush border membrane of enterocytes; plays a critical role in the absorption of intestinal cholesterol

  20. Niemann-Pick C1 Like 1 (NPC1L1) is required for intestinal uptake of both cholesterol and phytosterols and plays a major role in cholesterol homeostasis

Human NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) Interaktionspartner

  1. The variants of NPC1L1studied here had minor influence on serum noncholesterol sterolsand cholesterol metabolism.

  2. The results obtained from liver-specific NPC1L1 transgenic mouse (L1-Tg) crossed with LDLR-/- mouse indicated no feedback mechanism to inhibit NPC1L1 function in liver and hepatic expression of NPC1L1 correlated with VLDL secretion in hypercholesterolemia state.

  3. Lifelong, genetic inhibition of NPC1L1, mimicking treatment with ezetimibe, does not associate with risk of cancer.

  4. Due to their high affinity for the N-terminal domain of NPC1L1, black and cowpea bean peptides produced in the digestive track have the potential to disrupt interactions between NPC1L1 and membrane proteins that lead to cholesterol absorption

  5. These experiments demonstrate that cholesterol uptake by NPC1L1 does not require endocytosis; moreover, ezetimibe interferes with NPC1L1's cholesterol adsorption activity without blocking NPC1L1 internalization in RH7777 cells.

  6. Novel sequencing techniques are detecting rare variants with larger effect sizes (eg, NPC1L1) , which may further improve on Cardiovascular disease risk prediction.

  7. The results demonstrate that NPC1L1 recognizes alpha-tocopherol via its N-terminal domain and mediates alpha-tocopherol uptake through the same mechanism as cholesterol absorption.

  8. Simultaneously, these data indicate that R174H, V177I and V1284L NPC1L1 variations in high or low LDL-C individuals may not directly influence cholesterol absorption by NPC1L1.

  9. The results of this study identified the association between genetic susceptibility of the NPC1L1 gene and HCV infection, as well as biochemical characteristics of HCV-infected persons in Yunnan, China.

  10. exposure to LDL-C-lowering genetic variants in or near NPC1L1 and other genes was associated with a higher risk of type 2 diabetes. These data provide insights into potential adverse effects of LDL-C-lowering therapy.

  11. Detailed analysis of the role of NPC1L1 mutations in an exceptional responder to ezetimibe. The results point to a complex set of events in which the combined mutations were shown to affect cholesterol uptake in the presence of ezetimibe. Proteomic analysis suggests that the exceptional response may also lie in the nature of interactions with cytosolic proteins.

  12. Study suggests that the G allele of the NPC1L1 polymorphism g1679C>G may be a positive marker of gallstone formation risk.

  13. To study whether human NPC1L1 gene is regulated transcriptionally by LRH-1, we have analyzed evolutionary conserved regions (ECRs) in HepG2 cells.

  14. No significant association between investigated NPC1L1 variants and risk of coronary atherosclerosis could be observed.

  15. Results show that genetic variation in NPC1L1 is associated with a reduction in risk of IVD, with a corresponding reduction in LDL cholesterol, but with a concomitant increased risk of gallstone disease

  16. The frequencies of NPC1L1 polymorphisms in Chinese Hans are comparable to Japanese population but totally different from Caucasians, African-Americans and Hispanic individuals

  17. demonstrate that Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter, plays a central role in intestinal VK uptake and modulates the anticoagulant effect of warfarin. In

  18. Lipid-lowering response to ezetimibe is not impacted by the NPC1L1 polymorphisms studied in Chilean hypercholesterolemic subjects.

  19. NPC1L1-mediated cholesterol absorption is a major determinant of blood levels of apolipoprotein B-containing atherogenic lipoproteins

  20. The effect of lower LDL-C on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both is approximately the same per unit lower LDL-C and log-linearly proportional to the absolute exposure to lower LDL-C.

NPC1L1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit NPC1L1

  • NPC1 like intracellular cholesterol transporter 1 (NPC1L1)
  • NPC1 like 1 (npc1l1)
  • NPC1-like 1 (npc1l1)
  • NPC1 like intracellular cholesterol transporter 1 (Npc1l1)
  • 9130221N23Rik Protein
  • Gm243 Protein
  • NPC1L1 Protein
  • NPC11L1 Protein

Bezeichner auf Proteinebene für NPC1L1

NPC1-like 1 , NPC1 (Niemann-Pick disease, type C1, gene)-like 1 , Niemann-Pick C1-like protein 1 , Niemann-Pick C1-like 1 protein , Niemann-Pick C1-like protein 1-like , Niemann-Pick disease, type C1 , Niemann-Pick disease, type C1-like 1

GENE ID SPEZIES
463381 Pan troglodytes
539550 Bos taurus
610398 Canis lupus familiaris
699235 Macaca mulatta
100009042 Oryctolagus cuniculus
100030165 Monodelphis domestica
100458187 Pongo abelii
100478497 Ailuropoda melanoleuca
100487339 Xenopus (Silurana) tropicalis
100515982 Sus scrofa
100590536 Nomascus leucogenys
100616532 Danio rerio
237636 Mus musculus
432367 Rattus norvegicus
29881 Homo sapiens
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