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MMRN2 encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. Zusätzlich bieten wir Ihnen Multimerin 2 Antikörper (30) und Multimerin 2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Results provide evidence identifying MMRN2 as a key molecule in regulating endothelial cell (EC) function and demonstrate that, during the angiogenic stimulation, its expression is controlled both transcriptionally and post-translationally by MMP9 (zeige MMP9 ELISA Kits) for efficient EC sprouting.
Data identify MMRN2 as a specific ligand for CD93 (zeige CD93 ELISA Kits). CD93 (zeige CD93 ELISA Kits) and MMRN2 are co-expressed in the blood vessels of various tumors. Moreover, disruption of the CD93 (zeige CD93 ELISA Kits)-MMRN2 interaction reduced endothelial cell adhesion and migration. Site-directed mutagenesis identified different residue hotspots either directly or indirectly involved in the binding and propose a molecular model in which the coiled-coil domain of MMRN2 is engaged.
These findings identify novel protein interactions involving CLEC14A (zeige CLEC14A ELISA Kits), CD93 (zeige CD93 ELISA Kits) and CD248 (zeige CD248 ELISA Kits) with MMRN2 as targetable components of vessel formation
Results suggest that CLEC14A (zeige CLEC14A ELISA Kits)-MMRN2 binding has a role in inducing sprouting angiogenesis during tumor growth, which has the potential to be manipulated in future antiangiogenic therapy design.
CLEC14A (zeige CLEC14A ELISA Kits) is a matrix component which binds to MMRN2 in the process of endothelial cells transformation in tumor angiogenesis.
MMRN2 as a crucial player in the regulation of EC function, neo-angiogenesis and hence tumor growth
Mmrn2 interacts with anthrax protective antigen.
This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6.
, elastin microfibril interfacer 3
, EMILIN-like protein EndoGlyx-1
, elastin microfibril interface located protein 3
, endoGlyx-1 p125/p140 subunit