anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Antikörper

Mouse (Murine) Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Interaktionspartner

1. These interactions are required for SRC-induced activation of VAV and the subsequent engagement of a JIP1-tethered JNK signaling module.

2. Phosphorylation of KLC1 at Thr466 increased in aged brains, and JIP1 binding to kinesin-1 decreased, suggesting that APP transport is impaired by aging. Authors conclude that phosphorylation of KLC1 at Thr466 regulates the velocity of transport of APP by kinesin-1 by modulating its interaction with JIP1b.

3. It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.

4. Enhanced fast-velocity and efficient high-frequency APP anterograde transport observed in neurons are mediated by novel roles of JIP1b.

5. a simple yet modular mechanism for JIP1 scaffold assembly in mammals

6. There is a collaborative relationship between JIP1 and AKT that is required for axon growth and can be regulated by changes in neuronal activity.

7. identify plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 activation in CD8(+) T cells.

8. The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP transport in neurons.

9. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic beta cell death

10. JIP1 forms a trimetric complex with RBP-Jk and Notch1-IC, prevents physical association between Notch1-IC and RBP-Jk, sequesters RBP-JK in the cytoplasm, and suppresses the Notch1 signaling pathway.

11. Data suggest that JIP1-mediated JNK activation plays a critical role in metabolic stress regulation of the JNK signaling pathway.

12. JIP1b can directly modulate APP metabolism by interacting with the APP cytoplasmic domain, independent of its regulation of the JNK signaling cascade.

13. JIP-1 targets MKP-7 to dephosphorylate JNK.

14. The transient focal ischemic insult produced by middle cerebral artery occlusion (MCAO) strongly activated JNK in brain of jip1(+/+), jip1(+/-), and jip1(-/-) mice.

15. signaling network organized commonly by JIP1 and JSAP1 regulates the axon guidance in the developing brain.

16. the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP

17. POSH and JIPs directly associate with one another to form a multiprotein complex, PJAC (POSH-JIP apoptotic complex), that includes all of the known kinase components of the pathway.

18. IB1/JIP-1 monomers and dimers may differ in compartmental localization and thus function as a scaffold protein of the JNK signaling cascade in the cytoplasm or as a transcription factor in nuclei.

19. JIP scaffold proteins are critically required for normal NMDA receptor function.

20. This study shows that before primary cortical neurons become polarized, JIP1 specifically localizes to a single neurite and that after axonal specification,it accumulates in the emerging axon.

Human Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Interaktionspartner

1. extensive biochemical characterization of the KLC:JIP1 interaction, as well as identification of potential KLC1-binding partners, improves the understanding of how this growing family of cargos is recruited to kinesin1 by KLC1.

2. All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients.

3. analysis of the role of JIP1 in APP transport; knockdown of JIP1 did not affect either amyloid precursor protein transport or amyloid-beta peptide production

4. Data show that small GTPase RALA regulates formation of a JIP1 (C-Jun-amino-terminal-interacting protein 1) scaffold complex to propagate JNK signaling toward FOXO4 (forkhead box O transcription factor) in response to reactive oxygen species (ROS).

5. In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.

6. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic beta cell death

7. Data suggest that caspase 3-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK signalling during apoptotic cell death.

8. Data show that mechanical stress of urothelial cells activates in vivo JNK, as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 may be directly regulated by the AP-1 complex.

9. role in promoting transcription of amyloid beta protein precursor

10. results suggest that JIP-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP, and that the JNK signaling pathway may regulate the phosphorylation of this cargo protein through the JIP-1b scaffold

11. Promoter variant is associated with Alzheimer's disease.

12. JIP1 may act as an Akt1 scaffold, which regulates the enzymatic activity of Akt1 and can exert signaling effects independent of JNK activity

13. JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing

14. JIP-1 only facilitated (but is not required for) phosphorylation of Amyloid beta protein precursor but not of the two other family members APLP1 (amyloid precursor-like protein 1) and APLP2

15. stability is modulated by intracellular calcium

16. Growth control of prostate cancer cells can be mediated through JNK/c-Jun pathway, but androgen responsiveness can be independent of this pathway; androgen independence in progressive prostate cancer may not occur through activation of this pathway.

17. High IGF II expression was followed by high expression of JIP-1 in testicular neoplasms.

18. IB1/JIP-1 participates to the neuronal phenotype of the human LNCaP cells and is a regulator of JNK signaling pathway

19. JIP1 and JIP3, have a cross-talk that leads to the regulation of the ASK1-SEK1-JNK signal during glucose deprivation; cross-talk between JIP3 and JIP1 is mediated through SEK1-JNK2 and Akt1.

20. Altogether, our data demonstrate that Akt1 participates in a negative regulatory feedback loop by interacting with the JIP1 scaffold protein.