anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Antikörper

Mouse (Murine) Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Interaktionspartner

1. Phosphorylation of KLC1 (zeige KLC1 Antikörper) at Thr466 increased in aged brains, and JIP1 binding to kinesin-1 decreased, suggesting that APP (zeige APP Antikörper) transport is impaired by aging. Authors conclude that phosphorylation of KLC1 (zeige KLC1 Antikörper) at Thr466 regulates the velocity of transport of APP (zeige APP Antikörper) by kinesin-1 by modulating its interaction with JIP1b.

2. It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK (zeige MAPK8 Antikörper) signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.

3. Enhanced fast-velocity and efficient high-frequency APP (zeige APP Antikörper) anterograde transport observed in neurons are mediated by novel roles of JIP1b.

4. a simple yet modular mechanism for JIP1 scaffold assembly in mammals

5. There is a collaborative relationship between JIP1 and AKT (zeige AKT1 Antikörper) that is required for axon growth and can be regulated by changes in neuronal activity.

6. identify plenty of SH3 (POSH (zeige SH3RF1 Antikörper)) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 (zeige MAPK8 Antikörper) activation in CD8 (zeige CD8A Antikörper)(+) T cells.

7. The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP (zeige APP Antikörper) transport in neurons.

8. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (zeige MAP3K11 Antikörper) interaction with JIP1 scaffold protein (zeige HOMER1 Antikörper) in cytokine-induced pancreatic beta cell death

9. JIP1 forms a trimetric complex with RBP-Jk (zeige RBPJ Antikörper) and Notch1 (zeige NOTCH1 Antikörper)-IC, prevents physical association between Notch1 (zeige NOTCH1 Antikörper)-IC and RBP-Jk (zeige RBPJ Antikörper), sequesters RBP-JK (zeige RBPJ Antikörper) in the cytoplasm, and suppresses the Notch1 (zeige NOTCH1 Antikörper) signaling pathway.

10. Data suggest that JIP1-mediated JNK (zeige MAPK8 Antikörper) activation plays a critical role in metabolic stress regulation of the JNK (zeige MAPK8 Antikörper) signaling pathway.

Human Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Interaktionspartner

1. All binary complexes (KLC1 (zeige KLC1 Antikörper):APP (zeige APP Antikörper), KLC1 (zeige KLC1 Antikörper):JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 (zeige KLC1 Antikörper) and JIP1 may take part in APP (zeige APP Antikörper) transport in Alzheimer's disease patients.

2. analysis of the role of JIP1 in APP (zeige APP Antikörper) transport; knockdown of JIP1 did not affect either amyloid precursor protein (zeige APP Antikörper) transport or amyloid-beta peptide production

3. Data show that small GTPase (zeige RACGAP1 Antikörper) RALA (zeige rala Antikörper) regulates formation of a JIP1 (C-Jun (zeige JUN Antikörper)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (zeige MAPK8 Antikörper) signaling toward FOXO4 (zeige FOXO4 Antikörper) (forkhead box O (zeige FOXO Antikörper) transcription factor) in response to reactive oxygen species (ROS (zeige ROS1 Antikörper)).

4. In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.

5. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (zeige MAP3K11 Antikörper) interaction with JIP1 scaffold protein (zeige HOMER1 Antikörper) in cytokine-induced pancreatic beta cell death

6. Data suggest that caspase 3 (zeige CASP3 Antikörper)-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK (zeige MAPK8 Antikörper) signalling during apoptotic cell death.

7. Data show that mechanical stress of urothelial cells activates in vivo JNK (zeige MAPK8 Antikörper), as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 (zeige GJB2 Antikörper) may be directly regulated by the AP-1 (zeige FOSB Antikörper) complex.

8. results suggest that JIP (zeige SMAD4 Antikörper)-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP (zeige APP Antikörper), and that the JNK (zeige MAPK8 Antikörper) signaling pathway may regulate the phosphorylation of this cargo protein through the JIP (zeige SMAD4 Antikörper)-1b scaffold

9. JIP1 may act as an Akt1 (zeige AKT1 Antikörper) scaffold, which regulates the enzymatic activity of Akt1 (zeige AKT1 Antikörper) and can exert signaling effects independent of JNK (zeige MAPK8 Antikörper) activity

10. JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing