Protein Überblick

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Genbezeichner und Symbole assoziert mit MAPK8IP1

• mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1) Antikörper
• mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1) Antikörper

• IB1 Antikörper
• Jip-1 Antikörper
• JIP1 Antikörper
• Mapk8ip Antikörper
• mjip-2a Antikörper
• Alle Synonyme
• PRKM8IP Antikörper
• Skip Antikörper

Bezeichner auf Proteinebene für MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1 , c-Jun-amino-terminal kinase-interacting protein 1-like , C-Jun-amino-terminal kinase-interacting protein 1 , IB-1 , JNK MAP kinase scaffold protein 1 , JNK-interacting protein 1 , islet-brain-1 , mitogen activated protein kinase 8 interacting protein 1 , mitogen-activated protein kinase 8-interacting protein 1 , protein kinase, mitogen-activated 8 interacting protein , JIP-1-related protein , JRP , mitogen activated protein kinase 8 interacting protein , PRKM8 interacting protein , islet-brain 1 , islet brain 1