Mesoderm Development Candidate 2 (MESDC2) ELISA Kits

Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Zusätzlich bieten wir Ihnen MESDC2 Antikörper (49) und MESDC2 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
MESDC2 23184 Q14696
MESDC2 67943 Q9ERE7
MESDC2 308796 Q5U2R7
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Top MESDC2 ELISA Kits auf antikoerper-online.de

Showing 5 out of 10 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human
  96 Tests Anmelden zum Anzeigen 31 bis 41 Tage
$734.80
Details
Maus < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
$810.17
Details
Ratte < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
$810.17
Details
Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,029.60
Details
Huhn
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,095.60
Details

Weitere ELISA Kits für MESDC2 Interaktionspartner

Human Mesoderm Development Candidate 2 (MESDC2) Interaktionspartner

  1. Mesd C-terminal region constitutes the major LRP5 (zeige LRP5 ELISA Kits)/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer

  2. Results indicate that Mesd is a universal inhibitor of Wnt (zeige WNT2 ELISA Kits)/LRP (zeige RPSA ELISA Kits) signaling on the cell surface.

  3. Results provide evidence that MESD functions as a general LRP (zeige RPSA ELISA Kits) chaperone and suggest that the Mesd phenotype results from both signaling and endocytic defects resulting from misfolding of multiple LRP (zeige RPSA ELISA Kits) receptors.

  4. Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/LRP6 (zeige LRP5 ELISA Kits).

  5. a high bone mass mutant LRP5 (zeige LRP5 ELISA Kits)(G171V), has subtly reduced Dkk1 (zeige DKK1 ELISA Kits) binding, and, in contrast to LRP5 (zeige LRP5 ELISA Kits), no enhancement of binding with MesD

  6. as a result of (12;15)(q13;q25)translocation, the SUMO/Sentrin-specific protease 1 (zeige SENP1 ELISA Kits) gene (SENP1 (zeige SENP1 ELISA Kits)) on chromosome 12 and the embryonic polarity-related mesoderm development gene (MESDC2) on chromosome 15 are disrupted and fused

  7. Mesd and LRP6 (zeige LRP6 ELISA Kits) modulate Wnt (zeige WNT2 ELISA Kits) signaling.

Mouse (Murine) Mesoderm Development Candidate 2 (MESDC2) Interaktionspartner

  1. Mescd2 binds to Lrp4 (zeige CORIN ELISA Kits) and regulates Lrp4 (zeige CORIN ELISA Kits) surface expression in myotubes.

  2. Mesd C-terminal region constitutes the major LRP5 (zeige LRP5 ELISA Kits)/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer

  3. The region 45-184 of MESD is essential and sufficient to act as a molecular chaperone (zeige HSP90AA1 ELISA Kits) for the low-density lipoprotein receptor (LDLR (zeige LDLR ELISA Kits)) family.

  4. We show that MESD contains a central folded domain flanked by unstructured regions required to facilitate maturation of LRP6 (zeige LRP6 ELISA Kits). Enforced expression of human MESD promotes the secretion of soluble minireceptors derived from LRP6 (zeige LRP6 ELISA Kits).

  5. Functional analyses of the Lrp6 (zeige LRP6 ELISA Kits) rs mutant showed decreased targeting to plasma membrane because of reduced interaction with Mesoderm development (Mesd), a chaperone for Lrp6 (zeige LRP6 ELISA Kits), leading to impaired Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling

  6. Secondary structure prediction using chemical shift data indicates that MESD(12-155) contains four a-helices and five b-sheets.

  7. Mesd not only blocks binding of Dickkopf (zeige DKK1 ELISA Kits) (DKK)-1 (zeige DKK1 ELISA Kits) and sclerostin (zeige SOST ELISA Kits) proteins to low-density lipoprotein receptor (zeige LDLR ELISA Kits)-related protein (LRP (zeige LRP1 ELISA Kits))5 (zeige LRP5 ELISA Kits) and LRP6 (zeige LRP6 ELISA Kits) but also inhibits Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling in LRP5 (zeige LRP5 ELISA Kits)- or LRP6 (zeige LRP6 ELISA Kits)- expressing cancer cells.

  8. Together our results show that in addition to serving as a folding chaperone, Mesd can function as a receptor antagonist by inhibiting ligand binding to mature LRP6 (zeige LRP6 ELISA Kits).

MESDC2 Antigen-Profil

Beschreibung des Gens

Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway (By similarity).

Genbezeichner und Symbole assoziert mit MESDC2

  • mesoderm development LRP chaperone (MESD) Antikörper
  • mesoderm development LRP chaperone L homeolog (mesd.L) Antikörper
  • mesoderm development candidate 2 (CpipJ_CPIJ010816) Antikörper
  • mesoderm development candidate 2 (Tsp_04045) Antikörper
  • mesoderm development LRP chaperone (mesd) Antikörper
  • mesoderm development LRP chaperone (Mesd) Antikörper
  • mesoderm development candidate 2 (MESDC2) Antikörper
  • 2210015O11Rik Antikörper
  • AW537813 Antikörper
  • BOCA Antikörper
  • mesd Antikörper
  • MESDC2 Antikörper
  • MGC115616 Antikörper
  • mKIAA0081 Antikörper
  • msd Antikörper
  • zgc:158636 Antikörper

Bezeichner auf Proteinebene für MESDC2

mesoderm development candidate 2 , Mesoderm development candidate 2 , LDLR chaperone MESD , mesoderm development protein , renal carcinoma antigen NY-REN-61 , mesoderm development candiate 2

GENE ID SPEZIES
453586 Pan troglodytes
488765 Canis lupus familiaris
712993 Macaca mulatta
734603 Xenopus laevis
6043369 Culex quinquefasciatus
10904464 Trichinella spiralis
100135217 Xenopus (Silurana) tropicalis
100157638 Sus scrofa
100174652 Pongo abelii
23184 Homo sapiens
67943 Mus musculus
308796 Rattus norvegicus
514610 Bos taurus
415475 Gallus gallus
791222 Danio rerio
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