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associates with tyrosine-phosphorylated proteins to link the receptor with its substrate in the plasma membrane [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen MAGI3 Antikörper (16) und viele weitere Produktgruppen zu diesem Protein an.
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Our findings lend support to a genetic basis for modulation of intestinal epithelial barrier in IBD, and we have identified MAGI3 as a new candidate gene for IBD.
The altered mRNA isoform, called MAGI3(pPA (zeige PPA1 Proteine)), produces a truncated protein that acts in a dominant-negative manner to prevent full-length MAGI3 from interacting with the YAP (zeige YAP1 Proteine) oncoprotein, thereby relieving YAP (zeige YAP1 Proteine) inhibition and promoting malignant transformation of human mammary epithelial cells.
Results identify MAGI3 as a novel tumor suppressor and provide insight into the pathogenesis of glioma.
Expression levels of MAGI3 and PTEN were significantly downregulated in gliomas.
MAGI-3 competes with NHERF-2 (zeige SLC9A3R2 Proteine) to negatively regulate LPA2 (zeige LPAR2 Proteine) receptor signaling in colon cancer cells.
Oncogenic human papillomavirus E6 proteins target the MAGI-2 (zeige MAGI2 Proteine) and MAGI-3 proteins for degradation [MAGI-2 (zeige MAGI2 Proteine), MAGI-3]
In epithelial cells, MAGI-3 was localized with ZO-1 (zeige TJP1 Proteine) and cingulin at tight junctions, whereas in primary cultured astrocytes it was found in E-cadherin (zeige CDH1 Proteine)-based cell-cell contacts and in focal adhesion sites.
These results demonstrate that MAGI-3 interacts directly with LPA(2 (zeige LPAR2 Proteine)) and regulates the ability of LPA(2 (zeige LPAR2 Proteine)) to activate Erk (zeige EPHB2 Proteine) and RhoA (zeige RHOA Proteine).
All of the E6 genes from different HPV types displayed similar abilities to mediate the degradation of both p53 (zeige TP53 Proteine) and MAGI-3
MAGI-3 has a role in efficient trafficking of TGFalpha to the cell surface in polarized epithelial cells.
associates with tyrosine-phosphorylated proteins to link the receptor with its substrate in the plasma membrane
, membrane-associated guanylate kinase inverted 3
, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
, membrane-associated guanylate kinase-related (MAGI-3)
, scaffolding protein SLIPR
, scaffolding-like protein
, membrane-associated guanylate kinase-related 3