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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Zusätzlich bieten wir Ihnen Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Antikörper (366) und Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Kits (164) und viele weitere Produktgruppen zu diesem Protein an.
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Estrogen-related receptor gamma (ERRgamma (zeige ESRRG Proteine)) overexpression in chondrocytes directly upregulates matrix metalloproteinase (MMP)-3 and MMP13 (zeige MMP13 Proteine), which are known to play crucial roles in cartilage destruction in osteoarthritis (OA).
MMP3 contributes to the pathogenesis of ARDS by affecting the pulmonary inflammatory response in female mice in relevant models of lung injury.
endogenously secreted chemerin (zeige RARRES2 Proteine) plays an autocrine/paracrine role in white adipose tissue, identifying chemerin (zeige RARRES2 Proteine) as a therapeutic target to modulate adipose remodelling.
Overexpression of Mmp3 in 3T3-L1 preadipocytes inhibited differentiation. High fat diet-induced obesity downregulates adipocyte MMP3 expression to trigger adipogenesis, and adipocyte TIMP4 (zeige TIMP4 Proteine) may modulate this process to regulate hyperplastic vs. hypertrophic adipose tissue expansion, fat distribution, and metabolic health in a sex- and depot-dependent manner.
Matrix metalloprotease (zeige ADAMTS7 Proteine) 3 (MMP3), an endogenous neuronal activator of microglia, increased cytokine release from YAC128 microglia compared to wildtype microglia. We found elevated MMP levels in Huntington's Disease (HD) CSF (zeige CSF2 Proteine), and MMP levels correlate with disease severity in HD. These data support a novel role for MMPs and microglial activation in HD pathogenesis.
These results indicate that periodic induction, via use of an eye drop, of AAV-mediated secretion of MMP-3 into aqueous humour could have therapeutic potential for those cases of glaucoma that are sub-optimally responsive to conventional pressure-reducing medications.
Data show that loss of loss of matrix metalloproteinase-3 (MMP-3) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 (zeige CPT1B Proteine) and (C-X-C motif) ligand 1 (CXCL1 (zeige CXCL1 Proteine)).
Mmp3-knockout mice maintained higher arterial oxygenation compared to wild-type mice in a model of acute lung injury.
NMP4 (zeige ZNF384 Proteine) deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL (zeige TNFSF11 Proteine) and MMP-3 mRNA.
MMP-3 produced in blood vessel endothelial cells after spinal cord injury serves as an endogenous molecule for microglial activation followed by p38MAPK (zeige MAPK14 Proteine) activation and proNGF production
study to explore the relationship between 2 polymorphisms (MMP-1 (zeige MMP1 Proteine)-755 T/G [rs498186] and MMP-3 A/C [rs632478]) and disc degeneration; a significant association was found between the MMP-3 polymorphism and disc degeneration; the homozygote CC was associated with an increased risk of disc degeneration compared with the AA genotype
Higher serum MMP-3 levels in knee osteoarthritis reflect disease "generalization".
Report a positive correlation between glomerular filtration rate and MMP-3 activity in diabetic patients.
The maternal and fetal MMP3 gene polymorphisms may be strong genetic markers of preeclampsia, occurring either individually or together.
2G allele of MMP-1 (zeige MMP1 Proteine), C allele of MMP-2 (zeige MMP2 Proteine) and 5A/6A genotype of MMP-3 are associated with susceptibility and disease progression of type 2 diabetic nephropathy
MMP-1 (zeige MMP1 Proteine) genotype may accelerate the development of HIV-associated neurocognitive disorder (HAND) whereas MMP3 -1612 5A5A genotype may reduce the risk of pathogenesis of HAND.
Preliminary studies indicate that baseline MMP3 and TIMP3 (zeige TIMP3 Proteine) concentrations are associated with patient survival and disease-free time
MMP-3 (Lys45Glu) polymorphisms associate with obesity risk and its severity.
Data suggest that serum matrix metalloproteinase-3 (MMP-3) and the 7-joint ultrasound score (US7) scores could both effectively reflect disease activity and therapeutic responses in patients with moderate to severe rheumatoid arthritis (RA).
results demonstrated that measurement of MMP-3 could become a marker of disease activity in rheumatoid arthritis patients
The present study was aimed to determine the association between metalloproteinase 3 (MMP3), transforming growth factor beta 1 (TGFbeta1 (zeige TGFB1 Proteine)) and collagen type X alpha I (COL10A1 (zeige COL10A1 Proteine)) gene polymorphisms with traits related to leg weakness in pigs.
the identification of MMP1 (zeige MMP1 Proteine) and MMP10 (zeige MMP10 Proteine) genes in swine is reported.
contribution of MMPs to the inflammatory breakdown of the blood-CSF (zeige CSF2 Proteine) barrier in vitro
Results indicate that leukemia inhibitory factor (LIF (zeige LIF Proteine)) and Oncostatin M (zeige OSM Proteine) increase the expression of MMP-1 (zeige MMP1 Proteine), MMP-3, and TIMP-1 (zeige TIMP1 Proteine) several fold, and that their expression is reduced to basal levels in the presence of the LIF (zeige LIF Proteine) antagonist MH35-BD.
Compromised autophagy may be related to the osteoarthritis progression; JNK (zeige MAPK8 Proteine) and p38 (zeige MAPK14 Proteine) MAPKs up-regulate MMP3 and down-regulate autophagy.
chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.
Ulinastatin (zeige AMBP Proteine) effectively inhibited the increased expression of MMP-2 (zeige MMP2 Proteine), MMP-3, and iNOS (zeige NOS2 Proteine) in degenerated NP cells induced by IL-1beta (zeige IL1B Proteine) in vitro.
Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma (zeige PPARG Proteine) in atherosclerotic rabbits.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
, matrix metalloproteinase 3
, matrix metalloproteinase-3
, stromelysin 1
, PTR1 protein
, matrix metalloproteinase 3 (stromelysin 1, progelatinase)
, metalloproteinase 3 receptor
, matrix metallopeptidase 3 (stromelysin 1, progelatinase)
, matrix metalloproteinase 10 (stromelysin 2)