Matrix Metallopeptidase 11 (Stromelysin 3) Proteine (MMP11)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Zusätzlich bieten wir Ihnen MMP11 Antikörper (140) und MMP11 Kits (40) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MMP11 4320 P24347
MMP11 17385 Q02853
MMP11 25481 Q499S5
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Showing 10 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,744.22
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Escherichia coli (E. coli) Ratte His tag,S tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$864.00
Details
Escherichia coli (E. coli) Human His-GST 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 50 μg Anmelden zum Anzeigen 6 bis 9 Tage
$409.86
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$560.00
Details
Escherichia coli (E. coli) Maus His tag   100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$672.00
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,076.33
Details
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,081.83
Details
Escherichia coli (E. coli) Human His-GST   50 μg Anmelden zum Anzeigen 11 bis 12 Tage
$515.20
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$554.33
Details

MMP11 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human
,
Mouse (Murine) ,

Rat (Rattus) ,
,

Weitere Proteine zu Matrix Metallopeptidase 11 (Stromelysin 3) (MMP11) Interaktionspartnern

Human Matrix Metallopeptidase 11 (Stromelysin 3) (MMP11) Interaktionspartner

  1. Authors evaluated the expression of known targets of miR (zeige MLXIP Proteine)-125a and found that sirtuin-7 (zeige SIRT7 Proteine), matrix metalloproteinase-11, and c-Raf (zeige RAF1 Proteine) were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR (zeige MLXIP Proteine)-125a.

  2. Results revealed that MMP-11 high expression in oral squamous cell carcinoma (OSCC) samples can predict the progression, especially lymph node metastasis, and the survival of OSCC patients.

  3. A new prognostic model for HR-/HER2 (zeige ERBB2 Proteine)+ breast cancer based on the expression of MMP11 and CD2 (zeige CD2 Proteine) was developed and the distant metastasis-free survival for patients in the high-risk group according to our model was significantly lower than that for those in the low-risk group.

  4. HMGA1 (zeige HMGA1 Proteine) and MMP-11 may play a key role in the proliferation and progression of skin tumors in humans.

  5. These results demonstrated that miR (zeige MLXIP Proteine)-145 has an inhibitory role in TNBC malignancy by targeting MMP11 and Rab27a (zeige RAB27A Proteine), which might be potential therapeutic and diagnostic targets for TNBC.

  6. the data demonstrate that miR125a5p functions as a tumor suppressor gene and serves an important role in inhibiting osteosarcoma cell migration, invasion and EMT (zeige ITK Proteine) by targeting MMP11.

  7. MMP-11 overexpression is associated with aggressive tumor phenotype and unfavorable clinical outcome in urothelial carcinomas.

  8. Our study established that high serum levels of MMP-11 are associated with poor clinical outcome and may serve as a prognostic biomarker in colon cancer patients.

  9. Overexpression of MMP-11 was discovered in sera of cancer patients compared with normal control group as well as in multiple tumor tissue specimens, such as gastric cancer, breast cancer, and pancreatic cancer. At present, some evidence supports that MMP-11 may work as a significant tumor biomarker for early detection of cancer, tumor staging, prognostic analysis, monitoring recurrence [review]

  10. Matrix metalloproteinase 11 has a role in degenerating intervertebral disc disease

Mouse (Murine) Matrix Metallopeptidase 11 (Stromelysin 3) (MMP11) Interaktionspartner

  1. Strikingly, MMP11 overexpression protects against type 2 diabetes while Mmp11-/- mice exhibit hallmarks of metabolic syndrome.

  2. Results show that MMP-11 has a paracrine function during mammary gland development that might be harnessed to promote tumor progression, exposing a new link between development and malignancy.

  3. point-out the paradoxical role of MMP11 in favoring the onset and growth of lung metastases but limiting lung foci number, and inhibiting the cancer cell dissemination to other organs

  4. investigation of a potential role of MMP-11 in adipose tissue development

  5. The increased levels of ST-3 in the thymus may be due to the presence of macrophages responsible for clearance of apoptotic cells

  6. downregulated by deglycosylation of CD147 in hepatocarcinoma cells

  7. These data together provide compelling evidence into the function of MMP-11 and suggest that MMP-11 act as a tumor lymphatic metastasis-associated gene.

  8. These findings reveal that the tumor biological marker CD147 functionally mediates MMP-11, VEGF-A (zeige VEGFA Proteine) expression and tumor lymphatic metastasis.

  9. Mmp11 exhibits collagenolytic function against collagen VI under normal conditions.

  10. Our study describes the identification of MMP11 as a novel broadly expressed tumor associated antigen as target candidate for cancer immunotherapy.

Xenopus laevis Matrix Metallopeptidase 11 (Stromelysin 3) (MMP11) Interaktionspartner

  1. Transgenic tadpoles were prepared with an elastase promoter driving either the ST3 gene or the constitutively active form of Notch (zeige NOTCH1 Proteine) (IC).

  2. analysis of substrate specificity for stromelysin-3: alpha1-PI is unlikely to be a physiological substrate

  3. ST3 regulates cell fate and tissue morphogenesis through direct or indirect extracellular matrix remodeling

  4. Laminin receptor precursor cleavage by ST3 plays a role in both physiological and pathological processes.

  5. thyroid hormone (zeige PTH Proteine) regulation of Xenopus laevis Stromelysin-3 is mediated by a DNA element in the first intron

  6. Mutational analysis of the cleavage of the cancer-associated laminin receptor by stromelysin-3 reveals the contribution of flanking sequences to site recognition and cleavage efficiency.

  7. ST3 expression, in the absence of T3 hormone, caused significant muscle cell death in the tail of premetamorphic transgenic tadpoles

MMP11 Protein Überblick

Protein Überblick

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

Genbezeichner und Symbole assoziert mit MMP11

  • matrix metallopeptidase 11 (MMP11)
  • matrix metallopeptidase 11 (Mmp11)
  • matrix metallopeptidase 11 L homeolog (mmp11.L)
  • SL-3 Protein
  • ST3 Protein
  • Stmy3 Protein

Bezeichner auf Proteinebene für MMP11

MMP-11 , stromelysin III , stromelysin-3 , SL-3 , matrix metalloproteinase 11 , matrix metalloproteinase-11 , stromelysin 3 , Matrix metalloproteinase 11 (stromelysin 3) , ST3 , gene 14

GENE ID SPEZIES
4320 Homo sapiens
17385 Mus musculus
100101604 Oryctolagus cuniculus
25481 Rattus norvegicus
486408 Canis lupus familiaris
100153503 Sus scrofa
539109 Bos taurus
100713229 Cavia porcellus
379501 Xenopus laevis
Ausgewählte Anbieter für MMP11 Proteine (MMP11)
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