Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase Proteine (MGAT1)

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Zusätzlich bieten wir Ihnen Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase Antikörper (95) und Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase Kits (13) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MGAT1 4245 P26572
MGAT1 17308 P27808
Ratte MGAT1 MGAT1 81519 Q09325
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Showing 5 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Hefe Arabidopsis thaliana His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,243.17
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Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,254.17
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MGAT1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,
Mouse (Murine)
,

Weitere Proteine zu Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) Interaktionspartnern

Human Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) Interaktionspartner

  1. In this study we showed that the activation of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway culminates in the upregulation of MGAT1 enzyme both at transcriptional and post-transcriptional levels. We also showed that overexpression of the beta-catenin (zeige CTNNB1 Proteine) gene (CTNNB1 (zeige CTNNB1 Proteine)) increased the promoter activity of MGAT1.

  2. The presence of the rs4285184 polymorphism of the MGAT1 gene increased the risk for developing body fat associated with obesity in the Mexican population.

  3. MGAT1 is downregulated in peripheral blood mononuclear cells of galactosaemia patients.

  4. The authors show here that the luminal domain of GnT1IP-L contains its MGAT1 inhibitory activity.

  5. UDP-galactose (zeige B4GALT1 Proteine) (SLC35A2 (zeige SLC35A2 Proteine)) and UDP-N-acetylglucosamine (zeige MGAT4B Proteine) (SLC35A3 (zeige SLC35A3 Proteine)) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats).

  6. The IL2RA (zeige IL2RA Proteine) and IL7RA (zeige IL7R Proteine) variants had univariate association in MS and T1D, whereas the MGAT1 and CTLA-4 (zeige CTLA4 Proteine) variants associated with only MS or T1D, respectively.

  7. analysis of suppression of cancer progression by MGAT1 shRNA knockdown

  8. Genetic variants downstream MGAT1 seem to influence susceptibility to obesity. Moreover, these genetic variants affect the levels of serum unsaturated fatty acids and Delta desaturase indices, variables previously shown to correlate with obesity.

  9. The analysis enabled us to identify a new candidate gene, MGAT1, associated with weight in women.

Mouse (Murine) Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) Interaktionspartner

  1. The MGAT1 interacts with DGAT2 (zeige DGAT2 Proteine), which serves to synergistically increase the TAG biosynthesis and LD expansion, leading to enhancement of lipid accumulation in the liver and fat.

  2. this study shows that loss of O-GlcNAc transferase blocks T cell progenitor renewal, malignant transformation and peripheral T cell clonal expansion

  3. Inhibition of hepatic Mogat1 (zeige MOGAT1 Proteine) improves hepatic metabolic abnormalities without attenuating liver inflammation and injury.

  4. Data from transgenic mice suggest that a lack of complex N- and O-glycans impairs early embryo development and viability in vivo leading to delayed implantation and embryo loss; Mgat1 and C1galt1 are required for embryo development and implantation.

  5. analysis of suppression of cancer progression by MGAT1 shRNA knockdown

  6. the MGAT1 pathway induced by hepatic PPARgamma (zeige PPARG Proteine) is critically important in the development of hepatic steatosis during diet-induced obesity

  7. Mgat1 mutant oocytes had an altered zona pellucida (ZP) that was thinner than the control ZP, and they did not possess complex N-glycans

  8. analysis of developmental and nutritional regulation of monoacylglycerol lipase (zeige MGLL Proteine) and monoacylglycerol acyltransferase

Fruit Fly (Drosophila melanogaster) Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) Interaktionspartner

  1. MGAT1-dependent N-glycosylation shapes the synaptomatrix carbohydrate environment and endogenous lectin localization within this domain, to modulate retention of trans-synaptic signaling ligands driving synaptic scaffold recruitment during synaptogenesis.

  2. show that knockdown of Mgat1 in the central nervous system (CNS) of wild-type flies decreases locomotor activity and life span.

  3. beta1,2-N-acetylglucosaminyltransferase I-dependent N-glycans are required for locomotory activity, life span, and brain development in Drosophila

Cow (Bovine) Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) Interaktionspartner

  1. N-acetylglucosaminyltransferase I activity in the oviduct may contribute to the induction of glycosylation and thereby contributing to the provision of the optimal microenvironment for fertilization and early development of the embryos.

Arabidopsis thaliana Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) Interaktionspartner

Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) Protein Überblick

Protein Überblick

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene.

Genbezeichner und Symbole assoziert mit MGAT1

  • mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT1)
  • mannoside acetylglucosaminyltransferase 1 (Mgat1)
  • Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 1 (Mgat1)
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat1)
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase S homeolog (mgat1.S)
  • alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (LOC410105)
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (mgat1)
  • Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (mgat1)
  • alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (CGL1)
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase a (mgat1a)
  • CG13431 Protein
  • CGL Protein
  • COMPLEX GLYCAN LESS Protein
  • COMPLEX GLYCAN LESS 1 Protein
  • Dmel\\CG13431 Protein
  • dMGAT1 Protein
  • F20D10.360 Protein
  • F20D10_360 Protein
  • GB16928 Protein
  • GlcNAc-TI Protein
  • GlcNAcT1 Protein
  • GLCT1 Protein
  • GLYT1 Protein
  • GNT-1 Protein
  • GNT-I Protein
  • GNTI Protein
  • MGAT Protein
  • Mgat-1 Protein
  • MGAT1 Protein
  • N-ACETYLGLUCOSAMINYLTRANSFERASE I Protein
  • zgc:66030 Protein

Bezeichner auf Proteinebene für MGAT1

N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I , alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase , glcNAc-T I , GNT-I , CG13431-PA , Mgat1-PA , N-acetylglucosaminyltransferase I , MGAT1 gene for N-acetylglucosaminyltransferase , mannoside acetylglucosaminyltransferase 1 , alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase , UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I , mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase , Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

GENE ID SPEZIES
4245 Homo sapiens
17308 Mus musculus
37323 Drosophila melanogaster
81519 Rattus norvegicus
379038 Xenopus laevis
410105 Apis mellifera
462340 Pan troglodytes
491674 Canis lupus familiaris
496815 Xenopus (Silurana) tropicalis
534248 Bos taurus
707375 Macaca mulatta
100009521 Oryctolagus cuniculus
100172524 Pongo abelii
100196739 Salmo salar
100583691 Nomascus leucogenys
829981 Arabidopsis thaliana
393649 Danio rerio
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