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Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Zusätzlich bieten wir Ihnen MAEL Kits (6) und MAEL Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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MAEL promoter hypermethylation may have a role in de-repression of LINE-1 in human hypospermatogenesis
Report found that Mael is activated in proliferating cancer cells, where it serves to maintain genetic stability. Its depletion results in an increase in reactive oxygen species, followed by apoptosis or senescence.
Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR (zeige MLXIP Antikörper)-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1 (zeige MTSS1 Antikörper).
Study demonstrated that MAEL interacts with Snail (zeige SNAI1 Antikörper) and inhibit E-cadherin (zeige CDH1 Antikörper) promoter activity. MAEL is an oncogene (zeige RAB1A Antikörper) that plays an important role in the development and progression of colon cancer.
Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 (zeige PABPC1 Antikörper) in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs (zeige FBN1 Antikörper).
Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt (zeige AKT1 Antikörper)/GSK-3beta/Snail (zeige SNAI1 Antikörper) signaling.
These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation (zeige HELLS Antikörper).
MAEL HMG (zeige SSRP1 Antikörper)-box domain may contribute to MAEL function in selective processing of retrotransposon RNA into piRNAs.
an important role for Mael in early oogenesis and during germ-cell differentiation from embryonic stem cells
This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of transposable elements (TEs (zeige TES Antikörper)) and identifies the initiation of meiosis as an important step in (TE) control in the male germline.
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage (By similarity).
cancer/testis antigen 128
, maelstrom homolog
, protein maelstrom homolog
, spermatogenesis associated 35