anti-Maelstrom Spermatogenic Transposon Silencer (MAEL) Antikörper

Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Zusätzlich bieten wir Ihnen MAEL Kits (6) und MAEL Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MAEL 84944 Q96JY0
MAEL 98558 Q8BVN9
MAEL 364039  
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Top anti-MAEL Antikörper auf antikoerper-online.de

Showing 10 out of 11 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 4 bis 8 Tage
$522.50
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, WB Immunocytochemistry/Immunofluorescence: MAEL Antibody [NBP1-77139] - Immunofluorescence of Maelstrom in HeLa cells with Maelstrom antibody at 20 ug/mL. Western Blot: MAEL Antibody [NBP1-77139] - HeLa cell lysate with MAEL antibody at 1 ug/mL. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$488.73
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: MAEL Antibody - Immunohistochemical staining of human testis shows moderate cytoplasmic positivity in cells in seminiferous ducts. 100 μL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ELISA, ICC, WB Immunocytochemical staining of HeLa cells with MAEL polyclonal antibody at 5 ug/mL dilution. Western blot analysis of HeLa cells with MAEL polyclonal antibody at 1 ug/mL dilution. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$356.00
Details
Human Kaninchen Unkonjugiert IC, IF, ELISA, WB   100 μg Anmelden zum Anzeigen 11 bis 16 Tage
$587.71
Details
Human Kaninchen HRP ELISA   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$412.19
Details
Human Kaninchen FITC ELISA   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$412.19
Details
Human Kaninchen Biotin ELISA   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$412.19
Details
Human Kaninchen Unkonjugiert ELISA, IHC   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$412.19
Details

Weitere Antikörper gegen MAEL Interaktionspartner

Human Maelstrom Spermatogenic Transposon Silencer (MAEL) Interaktionspartner

  1. Four sterility-related genes, including BOLL, DDX4, HORMAD1, and MAEL, were found to have increased methylation at CpGs of the promoter regions and decreased mRNA expressions in nonobstructive azoospermia and hypospermatogenesis (HS) testis and are believed to be associated with HS.

  2. MAEL promoter hypermethylation may have a role in de-repression of LINE-1 in human hypospermatogenesis

  3. Report found that Mael is activated in proliferating cancer cells, where it serves to maintain genetic stability. Its depletion results in an increase in reactive oxygen species, followed by apoptosis or senescence.

  4. Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1.

  5. Study demonstrated that MAEL interacts with Snail and inhibit E-cadherin promoter activity. MAEL is an oncogene that plays an important role in the development and progression of colon cancer.

  6. Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs.

  7. Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3beta/Snail signaling.

  8. These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation.

Mouse (Murine) Maelstrom Spermatogenic Transposon Silencer (MAEL) Interaktionspartner

  1. MAEL HMG-box domain may contribute to MAEL function in selective processing of retrotransposon RNA into piRNAs.

  2. an important role for Mael in early oogenesis and during germ-cell differentiation from embryonic stem cells

  3. Authors provide evidence of functional significance of these complexes in Mael129 knockout mice that exhibit spermiogenic arrest with acrosome and flagellum malformation.

  4. This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of transposable elements (TEs) and identifies the initiation of meiosis as an important step in (TE) control in the male germline.

MAEL Antigen-Profil

Protein Überblick

Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage (By similarity).

Genbezeichner und Symbole assoziert mit MAEL

  • maelstrom spermatogenic transposon silencer (MAEL) Antikörper
  • maelstrom spermatogenic transposon silencer (Mael) Antikörper
  • 4933405K18Rik Antikörper
  • AU019877 Antikörper
  • CT128 Antikörper
  • RGD1309333 Antikörper
  • RP11-102C16.1 Antikörper
  • SPATA35 Antikörper

Bezeichner auf Proteinebene für MAEL

cancer/testis antigen 128 , maelstrom homolog , protein maelstrom homolog , spermatogenesis associated 35

GENE ID SPEZIES
84944 Homo sapiens
98558 Mus musculus
364039 Rattus norvegicus
541073 Bos taurus
100048945 Sus scrofa
Ausgewählte Anbieter für anti-MAEL (MAEL) Antikörper
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