anti-Maelstrom Spermatogenic Transposon Silencer (MAEL) Antikörper

Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Zusätzlich bieten wir Ihnen MAEL Kits (6) und MAEL Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Gen	GeneID	UniProt
MAEL	84944	Q96JY0
MAEL	98558	Q8BVN9
MAEL	364039

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Top anti-MAEL Antikörper auf antikoerper-online.de

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Katalog Nr.	Reaktivität	Wirt	Konjugat	Applikation	Menge	Anbieter	Lieferzeit	Preis	Details
ABIN5554985	Human	Kaninchen	Unkonjugiert	EIA, WB	0.1 mg	Anmelden zum Anzeigen	8 bis 11 Tage	$474.10	Details
ABIN4332347	Human	Kaninchen	Unkonjugiert	ELISA, ICC, IF, WB	0.1 mg	Anmelden zum Anzeigen	8 bis 11 Tage	$485.88	Details
ABIN5953053	Human	Kaninchen	Unkonjugiert	IHC, IHC (p)	100 μL	Anmelden zum Anzeigen	10 bis 13 Tage	$491.63	Details
ABIN478261	Human	Kaninchen	Unkonjugiert	ELISA, WB	100 μg	Anmelden zum Anzeigen	7 bis 9 Tage	$551.83	Details
ABIN5582906	Human	Kaninchen	Unkonjugiert	ELISA, ICC, WB	100 μg	Anmelden zum Anzeigen	11 bis 12 Tage	$355.73	Details
ABIN2305565	Human	Kaninchen	Unkonjugiert	IC, IF, ELISA, WB	100 μg	Anmelden zum Anzeigen	11 bis 16 Tage	$578.29	Details
ABIN6073986	Human	Kaninchen	HRP	ELISA	100 μg	Anmelden zum Anzeigen	11 bis 18 Tage	$412.19	Details
ABIN6073987	Human	Kaninchen	FITC	ELISA	100 μg	Anmelden zum Anzeigen	11 bis 18 Tage	$412.19	Details
ABIN6073988	Human	Kaninchen	Biotin	ELISA	100 μg	Anmelden zum Anzeigen	11 bis 18 Tage	$412.19	Details
ABIN6073985	Human	Kaninchen	Unkonjugiert	ELISA, IHC	100 μg	Anmelden zum Anzeigen	11 bis 18 Tage	$412.19	Details

Weitere Produktkategorien zu MAEL Antikörper

Weitere Antikörper gegen MAEL Interaktionspartner

Human Maelstrom Spermatogenic Transposon Silencer (MAEL) Interaktionspartner

MAEL promoter hypermethylation may have a role in de-repression of LINE-1 in human hypospermatogenesis
Report found that Mael is activated in proliferating cancer cells, where it serves to maintain genetic stability. Its depletion results in an increase in reactive oxygen species, followed by apoptosis or senescence.
Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR (zeige MLXIP Antikörper)-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1 (zeige MTSS1 Antikörper).
Study demonstrated that MAEL interacts with Snail (zeige SNAI1 Antikörper) and inhibit E-cadherin (zeige CDH1 Antikörper) promoter activity. MAEL is an oncogene (zeige RAB1A Antikörper) that plays an important role in the development and progression of colon cancer.
Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 (zeige PABPC1 Antikörper) in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs (zeige FBN1 Antikörper).
Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt (zeige AKT1 Antikörper)/GSK-3beta/Snail (zeige SNAI1 Antikörper) signaling.
These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation (zeige HELLS Antikörper).

Mouse (Murine) Maelstrom Spermatogenic Transposon Silencer (MAEL) Interaktionspartner

MAEL HMG (zeige SSRP1 Antikörper)-box domain may contribute to MAEL function in selective processing of retrotransposon RNA into piRNAs.
an important role for Mael in early oogenesis and during germ-cell differentiation from embryonic stem cells
This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of transposable elements (TEs (zeige TES Antikörper)) and identifies the initiation of meiosis as an important step in (TE) control in the male germline.

MAEL Antigen-Profil

Protein Überblick

Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage (By similarity).

Genbezeichner und Symbole assoziert mit MAEL

maelstrom spermatogenic transposon silencer (MAEL) Antikörper
maelstrom spermatogenic transposon silencer (Mael) Antikörper

4933405K18Rik Antikörper
AU019877 Antikörper
CT128 Antikörper
RGD1309333 Antikörper
RP11-102C16.1 Antikörper
SPATA35 Antikörper

Bezeichner auf Proteinebene für MAEL

cancer/testis antigen 128 , maelstrom homolog , protein maelstrom homolog , spermatogenesis associated 35

GENE ID	SPEZIES
84944	Homo sapiens
98558	Mus musculus
364039	Rattus norvegicus
541073	Bos taurus
100048945	Sus scrofa

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