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Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Zusätzlich bieten wir Ihnen MAEL Kits (6) und MAEL Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Four sterility-related genes, including BOLL, DDX4, HORMAD1, and MAEL, were found to have increased methylation at CpGs of the promoter regions and decreased mRNA expressions in nonobstructive azoospermia and hypospermatogenesis (HS) testis and are believed to be associated with HS.
MAEL promoter hypermethylation may have a role in de-repression of LINE-1 in human hypospermatogenesis
Report found that Mael is activated in proliferating cancer cells, where it serves to maintain genetic stability. Its depletion results in an increase in reactive oxygen species, followed by apoptosis or senescence.
Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1.
Study demonstrated that MAEL interacts with Snail and inhibit E-cadherin promoter activity. MAEL is an oncogene that plays an important role in the development and progression of colon cancer.
Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs.
Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3beta/Snail signaling.
These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation.
MAEL HMG-box domain may contribute to MAEL function in selective processing of retrotransposon RNA into piRNAs.
an important role for Mael in early oogenesis and during germ-cell differentiation from embryonic stem cells
Authors provide evidence of functional significance of these complexes in Mael129 knockout mice that exhibit spermiogenic arrest with acrosome and flagellum malformation.
This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of transposable elements (TEs) and identifies the initiation of meiosis as an important step in (TE) control in the male germline.
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage (By similarity).
cancer/testis antigen 128
, maelstrom homolog
, protein maelstrom homolog
, spermatogenesis associated 35