MYST Histone Acetyltransferase 2 (MYST2) ELISA Kits

Human MYST Histone Acetyltransferase 2 (MYST2) Interaktionspartner

1. results indicate that the N-terminal region of JADE1 functions as a platform that brings together the catalytic HBO1 subunit with its cognate H3-H4 substrate for histone acetylation

2. acts in concert with SNF2H-ACF1 to make the chromosome structure more accessible to canonical nucleotide excision repair factors

3. Hbo1 is another ERalpha coactivator that ubiquitinates ERalpha

4. Histone acetyltransferase binding to ORC1 (HBO1) is upregulated in bladder cancer.

5. The results demonstrate some connections between KAT7 upregulated in RA SFs and RA progression and present the inhibition of KAT7 activity as a novel therapeutic target for interfering RA disease.

6. Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2 have been presented.

7. KAT7-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1-mediated heterochromatin invasion into centromeres.

8. the possible binding sites and biological functions of HBO1, were identified.

9. Data show that HTLV-1 basic leucine zipper (bZIP) factor (HBZ) represses p53 activity by direct inhibition of the histone acetyltransferase (HAT) activity of p300/CBP and the HAT activity of HBO1: [HBZ]

10. This study demonstrates that CRL4(DDB2) is a novel ubiquitin ligase of HBO1.

11. Taken together, MYST2 is a repressed growth suppressor in AML mediating reduced acetylation of histone 4 at residue 5 and is associated with inferior AML patient survival.

12. Myst2-mediated histone acetylation may be required for recruitment of Oct4 to the Nanog promoter

13. Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1-JADE1 shuttling during organ regeneration.

14. Hbo1 modulated transcription by estrogen receptor-alpha. Hbo1 contributes to degradation of ER-alpha by ubiquitination through lysine 48.

15. HBO1, but not SRC-2, expression was reduced in testes of patients with androgen insensitivity syndromes compared to normal testes.

16. Phosphorylated Hbo1 expression is associated with breast cancer.

17. alternate choice of subunits associated with HBO1 can switch its specificity between H4 and H3 tails

18. Gemcitabine resistance is dependent on Plk1-mediated phosphorylation of Orc2 and Hbo1.

19. Modulation of Fbxw15 levels was able to differentially regulate histone H3K14 acetylation and cellular proliferation by altering HBO1 levels.

20. The protein domains required for the assembly and function of HBO1/ING complexes were shown. Multiple PHD finger domains in different subunits bound the histone H3 N-terminal tail with a specificity towards lysine 4 methylation.

Pig (Porcine) MYST Histone Acetyltransferase 2 (MYST2) Interaktionspartner

1. MYST2 gene was cloned; results demonstrated that 2872G > A substitution was significantly associated with the litter size of all parities in Large White sows and Landrace sows

Mouse (Murine) MYST Histone Acetyltransferase 2 (MYST2) Interaktionspartner

1. The data provides a useful resource for exploring Myst2 and Niam essential cellular functions and should contribute to deeper understanding of organism early development and survival as well as cancer.

2. a nonredundant role for KAT7 in the maintenance of Histone h 3 lusine 14 acetylation, which is intimately linked with the ability to develop a normal immune system, is reported.

3. These results indicate that BRPF3 forms a functional tetrameric complex with HBO1 but is not required for mouse development and survival

4. Taken together, MYST2 is a repressed growth suppressor in AML mediating reduced acetylation of histone 4 at residue 5

5. Brd1-mediated Hbo1 activity is crucial for efficient activation of CD8 expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 enhancers.

6. Myst2-mediated histone acetylation may be required for recruitment of Oct4 to the Nanog promoter

7. Modulation of Fbxw15 levels was able to differentially regulate histone H3K14 acetylation and cellular proliferation by altering HBO1 levels.

8. The Hbo1-Brd1 complex is the major H3K14 HAT required for transcriptional activation of erythroid developmental regulator genes.

9. the primary role of HBO1 in development is that of a transcriptional activator, which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development

10. reveal a direct regulatory connection between p53-responsive stress signaling and Hbo1-dependent chromatin pathways

11. FAD24 controls DNA replication by recruiting HBO1 to origins of DNA replication and is required for MCE during adipocyte differentiation.