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C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.. Zusätzlich bieten wir Ihnen Killer Cell Lectin-Like Receptor Subfamily F, Member 2 Proteine (2) und viele weitere Produktgruppen zu diesem Protein an.
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NKp65 utilizes a hemi-immunoreceptor tyrosine-based activation motif -like motif for cellular activation that requires Syk, although Syk appears not to be recruited to NKp65.
Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65
structure explains the exceptionally high affinity of the NKp65-KACL interaction compared with other cell-cell interaction pairs, which may compensate for the monomeric nature of NKp65 to achieve cell activation
Keratinocytes express KACL and are capable of stimulating NKp65-expressing cells in a KACL-dependent manner.
C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.
activating coreceptor NKp65 , killer cell lectin-like receptor subfamily F member 2 , lectin-like receptor F2