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The protein encoded by KRT13 is a member of the keratin gene family.
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this study reports that KRT13 plays a directive role in prostate cancer bone, brain, and soft tissue metastases
Keratin 13 gene is epigenetically suppressed during TGFB1 (zeige TGFB1 ELISA Kits)-induced epithelial-mesenchymal transition in a human keratinocyte cell line.
Four rare missense variants were identified (ACTBL2 (zeige ACTBL2 ELISA Kits) rs73757391 (5q11.2), BTD (zeige BTD ELISA Kits) rs200337373 (3p25.1), KRT13 rs150321809 (17q21.2) and MC2R (zeige MC2R ELISA Kits) rs104894658 (18p11.21)), but only MC2R (zeige MC2R ELISA Kits) rs104894668 had a large effect size (OR = 9.66).
KRT13 expression is associated with poor prognosis at multiple stages of disease progression
Loss of CK13 expression is associated with invasive oral squamous cell carcinoma.
Low KRT13 mRNA expression is associated with oral squamous cell carcinoma.
Decreased KRT13 was associated with Esophageal Squamous Cell Carcinoma.
Our data provide mechanistic insights into the epigenetic silencing of KRT13 genes in OSCC cells and might be useful for the development of diagnostic markers and novel therapeutic approaches against OSCCs.
The immunofluorescent staining pattern of Wnt1 (zeige WNT1 ELISA Kits) and CK7 (zeige KRT7 ELISA Kits) as well as Wnt1 (zeige WNT1 ELISA Kits) and CK13 was consistent with IHC results. Thus, in pleomorphic adenoma, Wnt (zeige WNT2 ELISA Kits) is involved in tumor cell differentiation of peripheral columnar cells forming solid nests
Immunoexpression of CK13 and CK17 (zeige KRT17 ELISA Kits) in light green-stained superficial cells was associated with more severe morphological atypia in tongue squamous cell carcinoma
denervation caused an increase of Keratin (Krt)13 expression around taste buds
K13 cooperates with Myc (zeige MYC ELISA Kits) to promote lymphoma through elevated NF-kappaB (zeige NFKB1 ELISA Kits).
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants\; however, not all variants have been described.
, cytokeratin 13
, keratin, type I cytoskeletal 13
, type I keratin KA13
, 47 kDa cytokeratin
, keratin complex 1, acidic, gene 13