KIAA0226 Proteine (KIAA0226)

Negatively regulates endocytic trafficking. Zusätzlich bieten wir Ihnen KIAA0226 Antikörper (60) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
KIAA0226 9711 Q92622
Maus KIAA0226 KIAA0226 100502698 Q80U62
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 2 bis 3 Tage
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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KIAA0226 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,

Weitere Proteine zu KIAA0226 Interaktionspartnern

Human KIAA0226 Interaktionspartner

  1. Rubicon thus functions as an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion.

  2. HCV, by differentially inducing the expression of Rubicon and UVRAG (zeige UVRAG Proteine), temporally regulated the autophagic flux to enhance its replication.

  3. This study demonistrated that KIAA0226 mutation impairs Rubicon endosomal localization

  4. New DNA sequencing technologies are enabling us to investigate the whole or large targeted proportions of the genome in a rapid, affordable, and comprehensive way. Exome and targeted sequencing rundataxin genes causing ataxia.

  5. Rubicon may thus be pivotal to generating an optimal intracellular immune response against microbial infection.

  6. Rubicon differentially targets signaling complexes, depending on environmental stimuli, and may function to coordinate various immune responses against microbial infection.

  7. Rubicon and PLEKHM1 (zeige PLEKHM1 Proteine) specifically and directly interact with Rab7 (zeige RAB7B Proteine) via their RH domain; this interaction is critical for their function; show Rubicon but not PLEKHM1 (zeige PLEKHM1 Proteine) uniquely regulates membrane trafficking via simultaneously binding both Rab7 (zeige RAB7B Proteine) and PI3-kinase (zeige PIK3CA Proteine)

  8. a critical role of the Rubicon RUN domain in PI3KC3 and autophagy regulation

  9. Rubicon serves as a previously unknown Rab7 (zeige RAB7B Proteine) effector to ensure the proper progression of the endocytic pathway.

  10. we report the identification of a family with three children affected with a new form of recessive ataxia, which we suggest naming 'Salih ataxia', and of a frameshift mutation of KIAA0226 (rundataxin) that segregates with the disease

Mouse (Murine) KIAA0226 Interaktionspartner

  1. Rubicon specifically interacts with the interferon (zeige IFNA Proteine) regulatory factor (IRF (zeige TRIM63 Proteine)) association domain (IAD) of IRF3 (zeige IRF3 Proteine), and this interaction leads to inhibition of the dimerization of IRF3 (zeige IRF3 Proteine), which negatively regulates interferon (zeige IFNA Proteine)-mediated antiviral response.

  2. Rubicon deficiency enhances autophagic flux in the heart and protects mice from lethality and reduction in stroke volume induced by LPS (zeige TLR4 Proteine).

  3. Data indicate that Rubicon (Kiaa0226) and NOX2 (gp91phox (zeige CYBB Proteine)) are involved in microtubule-associated protein (zeige SPAG5 Proteine) LC3 (zeige MAP1LC3A Proteine)-associated phagocytosis.

  4. Beclin 1 (zeige BECN1 Proteine) and its binding proteins orchestrate the precise function of the class III PI(3 (zeige PI3 Proteine))K in regulating autophagy at multiple steps.

  5. Two Beclin 1 (zeige BECN1 Proteine) associated proteins, Atg14L and Rubicon, were identified.

KIAA0226 Protein Überblick

Protein Überblick

Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity.

Genbezeichner und Symbole assoziert mit KIAA0226 Proteine (KIAA0226)

  • RUN and cysteine rich domain containing beclin 1 interacting protein (RUBCN)
  • KIAA0226 (KIAA0226)
  • RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein (Rubcn)
  • 5330403K09 Protein
  • Kiaa0226 Protein
  • mKIAA0226 Protein
  • Rubicon Protein

Bezeichner auf Proteinebene für KIAA0226 Proteine (KIAA0226)

KIAA0226 , RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein , RUN domain protein as Beclin 1-interacting and cysteine-rich containing , baron , beclin-1 associated RUN domain containing protein , run domain Beclin-1 interacting and cystein-rich containing protein , run domain Beclin-1 interacting and cysteine-rich containing protein , rundataxin

GENE ID SPEZIES
424920 Gallus gallus
460971 Pan troglodytes
9711 Homo sapiens
100502698 Mus musculus
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