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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Zusätzlich bieten wir Ihnen IL27 Kits (53) und IL27 Proteine (22) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 164 products:
Mouse (Murine) Monoclonal IL27 Primary Antibody für ICS, Neut - ABIN2689756
Hall, Silver, Hunter: The immunobiology of IL-27. in Advances in immunology 2012
Show all 7 Pubmed References
Mouse (Murine) Polyclonal IL27 Primary Antibody für WB - ABIN1043831
Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002
Mouse (Murine) Monoclonal IL27 Primary Antibody für WB - ABIN1043835
Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Mouse (Murine) Monoclonal IL27 Primary Antibody für FACS - ABIN4896017
Yoshida, Yoshimi, Yoshii, Kim, Dey, Xiong, Munasinghe, Yazawa, ODonovan, Maximova, Sharma, Zhu, Wang, Morse, Ozato: The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. in Immunity 2014
Human Monoclonal IL27 Primary Antibody für CyTOF, FACS - ABIN4900122
Seyerl, Kirchberger, Majdic, Seipelt, Jindra, Schrauf, Stöckl: Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. in European journal of immunology 2010
this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1 (zeige IL27RA Antikörper)) on fetal membranes in cases of preterm birth
results indicate that elevated IL-27 strongly correlates with EOS (zeige IKZF4 Antikörper) and may provide additional diagnostic value along with PCT (zeige UROD Antikörper).
serum interleukin-27 and interleukin-35 concentrations in patients with Guillain-Barre syndrome
Expression of IL-27 in the serum was markedly increased in patients with sepsis-induced myo (zeige IRF6 Antikörper)cardial dysfunction compared with that in controls.
IL-27 significantly inhibited the M2 macrophages polarization and dampened the proliferation, migration and metastasis of pancreatic cancer cells and as well enhanced the efficacy of gemcitabine.
IL-27 increased NLRP3 (zeige NLRP3 Antikörper) inflammasome activation in monocytes with enhanced release of IL-1 beta (zeige IL1B Antikörper).
this study shows that interleukin 27 is up-regulated in patients with active inflammatory bowel disease
IL-27 polymorphisms might play a protective role for the development of ulcerative colitis in the Mexican population
Nrf2 (zeige GABPA Antikörper) Induces IL-17D (zeige IL17D Antikörper) to mediate tumor and virus surveillance.
IL-27 stimulation activated STAT1 (zeige STAT1 Antikörper) and STAT3 (zeige STAT3 Antikörper) in HeLa and T98G cells, suggesting that IL-27 engages the STAT1 (zeige STAT1 Antikörper)/3 pathway, which then leads to the upregulation of IL-6 (zeige IL6 Antikörper), IP-10 (zeige CXCL10 Antikörper), and MIG (zeige CXCL9 Antikörper)
TTP (zeige ZFP36 Antikörper), encoded by Zfp36 (zeige ZFP36 Antikörper), degrades p28 (zeige GSTO1 Antikörper) to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.
these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1 (zeige TXNRD1 Antikörper)-like cells in celiac disease
endogenous levels of IL-27 affected the oncogenic properties of mutant p53 (zeige TP53 Antikörper) in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.
Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin (zeige LTF Antikörper).
Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS (zeige TLR4 Antikörper) injection compared with control specimens.
these findings highlight critical roles for IFN-gamma (zeige IFNG Antikörper) and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation
IL-27-induced Sca-1 (zeige Ly6a Antikörper)(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (zeige EOMES Antikörper) and Blimp1 (zeige PRDM1 Antikörper).
found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (zeige IL6 Antikörper) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27
We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.
These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interluekin 27
, interleukin 27
, interleukin 27 p28 subunit