anti-Interleukin 1 Receptor-Like 1 (IL1RL1) Antikörper

Mouse (Murine) Interleukin 1 Receptor-Like 1 (IL1RL1) Interaktionspartner

1. Results indicate that IL-33/ST2 signaling is functionally present in primary sensory neurons and contributes to pruritus in poison ivy ACD. Blocking IL-33/ST2 signaling may represent a therapeutic approach to ameliorate itch and skin inflammation related to poison ivy allergic contact dermatitis.

2. CLOCK temporally gates mast cell responses to IL-33 (zeige IL33 Antikörper) via regulation of ST2 (zeige SULT2A1 Antikörper) expression. Our findings provide novel insights into IL-33 (zeige IL33 Antikörper)/mast cell-associated physiology and pathologies.

3. an increased prevalence in neonatal mortality was observed in litters from dams lacking ST2

4. Taken together, the data demonstrate a critical role of MyD88 (zeige MYD88 Antikörper) in DCs and of IL-33 (zeige IL33 Antikörper) signaling via ST2 (zeige SULT2A1 Antikörper) in MC903-induced Atopic dermatitis (AD). These data suggest that IL-33 (zeige IL33 Antikörper)/IL-33R may be a therapeutic target of AD.

5. Heligmosomoides polygyrus Alarmin Release Inhibitor (HpARI) prevents binding of active interleukin-33 (IL-33 (zeige IL33 Antikörper)) to the IL-33 (zeige IL33 Antikörper) receptor.

6. this study shows that ST2 (zeige SULT2A1 Antikörper) regulates early IL-13 (zeige IL13 Antikörper) production in fungus-induced allergic airway inflammation

7. mice deficient in the receptor for IL-33 (zeige IL33 Antikörper) (Il1rl1-/-) demonstrated enhanced lung clearance of Aspergillus fumigatus

8. This stuidy shown that the mRNA expression of IL-33 and ST2 receptors is increased in the CNS of Rocio virus-infected WT mice and that ST2(-/-) mice showed increased susceptibility to infection.

9. Liver Treg cells show a high expression of ST2 (zeige SULT2A1 Antikörper), a cellular receptor for tissue alarmin IL-33 (zeige IL33 Antikörper), which is strongly upregulated in the liver of infected mice. These results illustrate the importance of IL-33 (zeige IL33 Antikörper) in the suppressive function of liver Treg cells during Cytomegaloviruses (CMVs) infection.

10. these studies establish a basal defect in eosinophilopoiesis in IL-33 (zeige IL33 Antikörper)- and ST2 (zeige SULT2A1 Antikörper)-deficient mice and a mechanism whereby IL-33 (zeige IL33 Antikörper) supports eosinophils by driving both systemic IL-5 (zeige IL5 Antikörper) production and the expansion of IL-5Ralpha-expressing precursor cells

Human Interleukin 1 Receptor-Like 1 (IL1RL1) Interaktionspartner

1. Foxp3 (zeige FOXP3 Antikörper)(+) cells in the brains of Multiple sclerosis patients predominantly produce interleukin-10 (IL-10 (zeige IL10 Antikörper)) and show high expression of the IL-33 (zeige IL33 Antikörper) receptor ST2 (zeige SULT2A1 Antikörper).

2. In patients with stable mild to moderate chronic heart failure with reduced ventricular ejection fraction, a single measurement of sST2 (zeige SSTR2 Antikörper) protein and glucose were independent variables for hospitalization due to worsening CHF over a 1-year follow-up period.

3. present study highlights significant associations between ST2 and inflammatory bowel disease.

4. Data show that interleukin-2 receptor alpha (zeige IL2RA Antikörper), tumor necrosis factor receptor 1 (zeige TNFRSF1A Antikörper), serum STimulation-2 (IL1RL1 gene product), and regenerating islet-derived 3-alpha (zeige REG3A Antikörper) were significantly associated with non-relapse mortality.

5. Serum IL-33 (zeige IL33 Antikörper) and sST2 (zeige SSTR2 Antikörper) levels, and CD4 (zeige CD4 Antikörper)+ST2L+ expression in peripheral blood mononuclear cells are closely associated with HIV-1 infection and immune reconstitution in patients received highly-active antiretroviral therapy.

6. Elevated levels of sST2 (zeige SSTR2 Antikörper) concentration in stable coronary heart disease patients may independently predict short- and long-term risk for fatal CVD events and total mortality but not non-fatal CVD events.

7. Patients with severe aortic valve stenosis present elevated sST2 (zeige SSTR2 Antikörper) levels. Left ventricular global longitudinal strain resulted the only independent predictor of sST2 (zeige SSTR2 Antikörper) levels.

8. The Il1RL1 rs950880 AA homozygote is an independent predictor of all-cause mortality in coronary artery disease and peripheral arterial disease patients.

9. In a cohort of hypertensive heart failure subjects, soluble ST2 correlates significantly with indicators of right ventricular function.

10. Data provide evidence that increased IL-33/ST2 levels in patients with chronic kidney disease are an indicator of increased inflammation, impaired endothelial functions, and cardiovascular events.