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IFI6 was first identified as one of the many genes induced by interferon.
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Consequent to its localisation on inner-mitochondrial membrane, mtROS were higher in G1P3-expressing cells (MCF-7G1P3). This study identified that G1P3-induced mtROS have a direct role in migratory structure formation and nuclear gene expression to promote breast cancer cell metastasis.
Data suggest that p7 is a critical immune evasion protein that suppresses the antiviral interferon (zeige IFNA ELISA Kits) function by counteracting the function of IFI6-16.
In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1 (zeige GBP1 ELISA Kits), TLR3 (zeige TLR3 ELISA Kits), OAS1 (zeige OAS1 ELISA Kits), EIF2AK2 (zeige EIF2AK2 ELISA Kits), HLA-E (zeige HLAE ELISA Kits), IFI6, and STAT1 (zeige STAT1 ELISA Kits), showed higher expression in the islet core compared with the peri (zeige PLIN1 ELISA Kits)-islet area containing the surrounding immune cells
In conclusion, over-expression of IFI6 promotes hepatitis C virus RNA replication and rescues the interferon alpha (zeige IFNA ELISA Kits)-mediated anti-hepatitis C virus activity.
IFI6 inhibits HCV entry by impairing EGFR (zeige EGFR ELISA Kits) mediated CD81 (zeige CD81 ELISA Kits)/CLDN1 (zeige CLDN1 ELISA Kits) interactions. This may be relevant to other virus entry processes employing EGFR (zeige EGFR ELISA Kits).
Here we elucidate G1P3, a survival protein induced by interferons (IFNs), as a target of estrogen signaling and a contributor to poor outcomes in estrogen receptor (zeige ESR1 ELISA Kits)-positive (ER(+)) breast cancer.
PRINS regulates G1P3, a gene with anti-apoptotic effects in keratinocytes. siRNA-mediated inhibition of PRINS gene resulted in altered cell morphology and gene expression alterations.
G1P3 protein may have function as a cell survival protein by inhibiting mitochondrial-mediated apoptosis
Respiratory syncytial virus upregulated the mRNA expression of chemokines CC and CXC and interfered with type alpha/beta interferon (zeige IFNA ELISA Kits)-inducible gene expression by upregulation of MG11 (zeige SAMHD1 ELISA Kits) and downregulation of G1P3.
IFN-alpha2b induced the expression of G1P3 and antagonized the TRAIL induced apoptosis in myeloma suggesting that either the deregulated or the induced expression of G1P3 could lead to apoptosis resistance in tumor cells.
This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described.
interferon alpha-inducible protein 6
, interferon, alpha-inducible protein clone IFI-6-16
, interferon-induced protein 6-16