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Members of the Ikaros (ZNFN1A1\; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]..
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this study reports that IL-6 actively suppressed Eos mRNA and protein expression through miR-17
Ikaros (zeige IKZF1 ELISA Kits) may not be a conventional activator or repressor of defined sets of genes, but may sharpen the dynamic range of gene expression changes during developmental transitions
Eos is redundant for regulatory T cell function but plays an important role in IL-2 (zeige IL2 ELISA Kits) and IL-17 (zeige IL17A ELISA Kits) production by CD4 (zeige CD4 ELISA Kits)+ conventional T cells.
Data indicate that miR-17 promotes TH17 differentiation by repressing target Ikaros Family Zinc Finger 4 (IKZF4).
We show that reprogramming is controlled by downregulation of the transcription factor Eos (Ikzf4), an obligate corepressor for Foxp3 (zeige FOXP3 ELISA Kits).
Data suggest that Eos, MITF (zeige MITF ELISA Kits), and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitor cells.
study identified Eos as a critical mediator of Foxp3 (zeige FOXP3 ELISA Kits)-dependent gene silencing in CD4 (zeige CD4 ELISA Kits)+ regulatory T cells (Tregs); Eos interacts directly with Foxp3 (zeige FOXP3 ELISA Kits) and induces chromatin modifications that result in gene silencing in Tregs
IKZF4 polymorphism (rs1701704) was strongly associated with insulin (zeige INS ELISA Kits) autobody positivity at the time of type 1 diabetes diagnosis
Members of the Ikaros (ZNFN1A1\; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.
ikaros family zinc finger protein 4
, zinc finger protein Eos
, zinc finger protein, subfamily 1A, 4 (Eos)
, zinc finger protein, subfamily 1A, 4
, zinc finger transcription factor Eos