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The product of GNLY is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation.
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Human GNLY ELISA Kit für Sandwich ELISA - ABIN455256
Park, Choi, Park, Lee, Sung, Park, Kim, Choi, Jung, Kim: Pretreatment serum level of 15-kDa granulysin might have a prognostic value in patients with diffuse large B cell lymphoma. in Acta haematologica 2011
These results suggest that the 15 kDa granulysin exhibits a novel mechanism in bacteria killing in a way that's different from most antimicrobial peptides.
Decreased blood granulysin at the protein level, is linked to the immunological condition of latent tuberculosis infection.
Carbamate pesticides significantly reduced the intracellular levels of perforin (zeige PRF1 ELISA Kits), GrA (zeige NR3C1 ELISA Kits), GrB, Gr3 (zeige PRLHR ELISA Kits)/K, and GRN (zeige GRN ELISA Kits) in NK-92CI cells.
serum GNLY is closely associated with the clinical characteristics of nasopharyngeal carcinoma and may be a potential biomarker for nasopharyngeal carcinoma
GNLY delivers Gzms into three protozoan parasites (Trypanosoma cruzi, Toxoplasma gondii and Leishmania major), in which the Gzms generate superoxide and inactivate oxidative defense enzymes to kill the parasite.
Studies indicate that cytotoxic mechanisms mediated by granulysin and TRAIL (TNF-related apoptosis inducing ligand (zeige TNFSF10 ELISA Kits)) seem to be less secondary effects on normal tissues.
High Granulysin expression is associated with Cutaneous T Cell Lymphoma and Sezary Syndrome.
A three-way interaction between SNPs in HLA-DQ and GNLY was identified in terms of HBV clearance.
GNLY-expressing lymphocytes, probably attracted by IL-15 (zeige IL15 ELISA Kits), not only participate partially in myocardial cell apoptosis, but also hasten resolution of cardiac leukocyte infiltration in patients with myocardial infarction.
Serum granulysin levels were significantly elevated in both acute and chronic alopecia areata patients.
Intercaruncular epithelium granulysin may play important roles in the establishment and maintenance of gestation during normal pregnancy.
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
, T-cell activation protein 519
, T-lymphocyte activation gene 519
, lymphocyte-activation gene 2
, lymphokine LAG-2