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Gp120 Proteine

80 Treffer:

Gp120 (Gp120) (AA 36-507) (Active) protein (His tag) Protein

Gp120 Spezies: Human Immunodeficiency Virus (HIV) Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed 4
Produktnummer ABIN2181170
$286.00
Zzgl. Versandkosten $45.00
100 μg (More quantities available)
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 2 bis 3 Werktagen

Gp120 (Gp120) (AA 36-511) protein (His tag) Protein

Gp120 Spezies: Human Immunodeficiency Virus (HIV) Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Produktnummer ABIN2181174
$286.00
Zzgl. Versandkosten $45.00
100 μg (More quantities available)
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 2 bis 3 Werktagen

Gp120 (Gp120) (AA 34-506) (Active) protein (His tag) Protein

Gp120 Spezies: Human Immunodeficiency Virus (HIV) Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN2181172
$385.00
Zzgl. Versandkosten $45.00
100 μg (More quantities available)
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 Werktagen

Gp120 (Gp120) (AA 29-503), (Extracellular Domain) protein (His tag) Protein

Gp120 Spezies: Human Immunodeficiency Virus (HIV) Wirt: Human Cells Recombinant > 95 % as determined by SDS-PAGE SDS
Pubmed 2
Produktnummer ABIN2650304
$581.16
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 13 Werktagen

Gp120 (Gp120) (AA 36-507) (Active) protein (His tag,AVI tag,Biotin) Protein

Gp120 Spezies: Human Immunodeficiency Virus (HIV) Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN5954901
$1,518.00
Zzgl. Versandkosten $45.00
200 μg (More quantities available)
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 Werktagen

Gp120 (Gp120) (AA 32-504) protein (His tag) Protein

Gp120 Spezies: Human Immunodeficiency Virus (HIV) Wirt: Human Cells Recombinant > 90 % as determined by SDS-PAGE. SDS
Produktnummer ABIN2007116
$581.16
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 13 Werktagen

Gp120 (Gp120) (AA 31-509) protein (His tag) Protein

Gp120 Spezies: Human Immunodeficiency Virus (HIV) Wirt: Human Cells Recombinant > (83.7+6.7)% as determined by SDS-PAGE. SDS
Produktnummer ABIN2215532
$581.16
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 13 Werktagen

Gp120 (Gp120) (AA 31-494), (Extracellular Domain) protein (His tag) Protein

Gp120 Spezies: Human Immunodeficiency Virus (HIV) Wirt: Human Cells Recombinant > 85 % as determined by SDS-PAGE. SDS
Produktnummer ABIN2215533
$581.16
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 13 Werktagen

Gp120 (Gp120) (AA 30-509) protein (His tag) Protein

Gp120 Spezies: Human Immunodeficiency Virus (HIV) Wirt: Human Cells Recombinant > (85.5+6.2) % as determined by SDS-PAGE. SDS
Produktnummer ABIN2215535
$581.16
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 13 Werktagen

Gp120 (Gp120) (AA 38-527), (Extracellular Domain) protein (His tag) Protein

Gp120 Spezies: Human Immunodeficiency Virus (HIV) Wirt: Human Cells Recombinant > 90 % as determined by SDS-PAGE. SDS
Produktnummer ABIN2650367
$581.16
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 13 Werktagen
  • Typ Protein
    • Protein
  • Target Gp120
    • Gp120
    • Hemagglutinin (HA)
    • Hemoglobin beta (HBB)
    • Ribosome Binding Factor A (RBFA)
    • Triosephosphate Isomerase 1 (TPI1)
    • S-Adenosyl-Methionine Synthase (METK)
    • Hemoglobin, alpha 1 (HBA1)
    • Myoglobin (MB)
    • Tumor Necrosis Factor alpha (TNF alpha)
    • Thymidylate Kinase (Tmk)
    • Lipoyl synthase (lipA)
    • Growth Hormone 1 (GH1)
    • Interferon gamma (IFNG)
    • Aspartate Carbamoyltransferase (PYRB)
    • Phenylalanyl-tRNA Synthetase, alpha Subunit (FARSA)
    • Uracil-DNA Glycosylase (UNG)
    • Malate Dehydrogenase (MDH)
    • Phosphoglucosamine Mutase (GLMM)
    • SARS-CoV-2 Spike
    • Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1)
    • phosphatidylserine Decarboxylase (PISD)
    • Cysteinyl-tRNA Synthetase 2, Mitochondrial (Putative) (CARS2)
    • tRNA Methyltransferase 5 (TRMT5)
    • Queuine tRNA-Ribosyltransferase 1 (QTRT1)
    • Interleukin 6 (IL6)
    • Interleukin 2 (IL2)
    • Cytochrome C, Somatic (CYCS)
    • Interleukin 4 (IL4)
    • CD40 Ligand (CD40LG)
    • Porphobilinogen Deaminase (HEMC)
    • Plasminogen Activator Inhibitor 1 (SERPINE1)
    • Superoxide Dismutase 1, Soluble (SOD1)
    • Epidermal Growth Factor Receptor (EGFR)
    • 1-(5-Phosphoribosyl)-5-[(5-Phosphoribosylamino)methylideneamino] Imidazole-4-Carboxamide Isomerase (APG10)
    • Interleukin 10 (IL10)
    • Interleukin 8 (IL8)
    • Interleukin 1, beta (IL1B)
    • Prolactin (PRL)
    • Vascular Endothelial Growth Factor A (VEGFA)
    • Adenosylhomocysteinase (AHCY)
    • Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2)
    • Ferrochelatase, HEMH (HEMH)
    • Thymidylate Synthase (THYA)
    • SARS-CoV-2 Spike S1
    • Uracil Phosphoribosyltransferase (UPP)
    • beta-2-Microglobulin (B2M)
    • Thymidine Kinase 1, Soluble (TK1)
    • Insulin-Like Growth Factor 1 (IGF1)
    • Programmed Cell Death 1 (PDCD1)
    • Ribonuclease, RNase A Family, 1 (Pancreatic) (RNASE1)
    Please use search to find more...
  • Anwendung
    • ELISA
    • Western Blotting (WB)
    • Immunogen (Imm)
    • SDS-PAGE (SDS)
  • Reaktivität
    • Human Immunodeficiency Virus (HIV)
    • Simian Immunodeficiency Virus (SIV)
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Wirt
    • HEK-293 Cells
    • Human Cells
    • Human
  • Bindungsspezifität
    • Clade B
    • Clade A
    • Clade C
    • AA 35-501
    • Extracellular Domain
    • AA 36-507
    • AA 18-533
    • AA 21-523
    • AA 22-513
    • AA 23-501
    • AA 23-509
    • AA 23-533
    • AA 24-515
    • AA 27-513
    • AA 28-501
    • AA 28-505
    • AA 28-506
    • AA 29-479
    • AA 29-501
    • AA 29-503
    • AA 29-506
    • AA 29-507
    • AA 29-514
    • AA 30-495
    • AA 30-498
    • AA 30-499
    • AA 30-502
    • AA 30-503
    • AA 30-506
    • AA 30-509
    • AA 30-513
    • AA 30-514
    • AA 30-523
    • AA 31-494
    • AA 31-497
    • AA 31-499
    • AA 31-500
    • AA 31-502
    • AA 31-503
    • AA 31-504
    • AA 31-508
    • AA 31-509
    • AA 31-511
    • AA 31-524
    • AA 31-528
    • AA 31-530
    • AA 32-504
    • AA 32-505
    • AA 32-512
    • AA 32-513
    Please use search to find more...
  • Konjugat
    • Unkonjugiert
    • His tag
    • His tag,AVI tag,Biotin
  • Protein-Typ
    • Recombinant
  • Format
    • Liquid
    • Lyophilized
  • Biologische Aktivität
    • Active

Gp120 Protein Überblick

Protein Überblick

The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). {ECO:0000250}. Surface protein gp120 (SU) may target the virus to gut- associated lymphoid tissue (GALT) by binding host ITGA4/ITGB7 (alpha-4/beta-7 integrins), a complex that mediates T-cell migration to the GALT. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T- cell depletion is believed to be the major insult to the host immune system leading to AIDS (By similarity). {ECO:0000250}. The surface protein gp120 is a ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses. These interactions allow capture of viral particles at mucosal surfaces by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they take up antigen, process it, and present it to T-cells following migration to lymphoid organs. SIV subverts the migration properties of dendritic cells to gain access to CD4+ T-cells in lymph nodes. Virus transmission to permissive T-cells occurs either in trans (without DCs infection, through viral capture and transmission), or in cis (following DCs productive infection, through the usual CD4-gp120 interaction), thereby inducing a robust infection. In trans infection, bound virions remain infectious over days and it is proposed that they are not degraded, but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the viral infectious potential during DCs' migration from the periphery to the lymphoid tissues. On arrival at lymphoid tissues, intact virions recycle back to DCs' cell surface allowing virus transmission to CD4+ T-cells. Virion capture also seems to lead to MHC-II-restricted viral antigen presentation, and probably to the activation of SIV-specific CD4+ cells (By similarity). {ECO:0000250}. The transmembrane protein gp41 (TM) acts as a class I viral fusion protein. Under the current model, the protein has at hairpin intermediate state, and post-fusion hairpin state. During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Complete fusion occurs in host cell endosomes. The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity). {ECO:0000250}. The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface. {ECO:0000250}. The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo- galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity). {ECO:0000250}.

Genbezeichner und Symbole assoziert mit Gp120 Proteine (Gp120)

  • envelope protein (env) Antikörper

Bezeichner auf Proteinebene für Gp120 Proteine (Gp120)

Env polyprotein

GENE ID SPEZIES
1490007 Simian immunodeficiency virus

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