anti-Glucosidase beta 2 (GBA2) Antikörper

Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. Zusätzlich bieten wir Ihnen GBA2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GBA2 230101 Q69ZF3
GBA2 298399  
GBA2    
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Top anti-GBA2 Antikörper auf antikoerper-online.de

Showing 3 out of 3 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ELISA, IF, WB Western Blot (WB) analysis of specific cells using Glucosidase IIbeta Polyclonal Antibody. 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Human Kaninchen Unkonjugiert ELISA, IF, WB   200 μL Anmelden zum Anzeigen 12 bis 14 Tage
$438.90
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Human Kaninchen Unkonjugiert ELISA, WB   50 μL Anmelden zum Anzeigen 11 bis 16 Tage
$412.19
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GBA2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Mouse (Murine)


Rat (Rattus)


Human


Weitere Antikörper gegen GBA2 Interaktionspartner

Mouse (Murine) Glucosidase beta 2 (GBA2) Interaktionspartner

  1. sphingosine, the cytotoxic metabolite accumulating in Gaucher cells through the action of GBA2, directly binds to GBA2 and inhibits its activity.

  2. GBA2 is particularly abundant in Purkinje cells (PCs), one of the most affected neuronal populations in NPC (zeige NPC1 Antikörper) disease.

  3. glucosylceramide accumulation in GBA2 knockout-mice alters cytoskeletal dynamics due to a more ordered lipid organization in the plasma membrane. Similar cytoskeletal defects were observed in male germ and Sertoli cells from GBA2 knockout-mice.

  4. the deletion of Gba2 significantly rescues the type 1 Gaucher disease clinical phenotype.

  5. redefine GBA2 activity as the beta-glucosidase that is sensitive to inhibition by N-butyldeoxygalactonojirimycin.

  6. GBA2 is localized at the ER and Golgi, which puts GBA2 in a key position for a lysosome-independent route of glucosylceramide-dependent signaling.

  7. The repression of IL-6 (zeige IL6 Antikörper)/STAT3 (zeige STAT3 Antikörper) signalling pathway seems to be one of the mechanisms for the delay of liver regeneration in GBA2-deficient mice.

  8. GBA1 (zeige GBA Antikörper) and GBA2 activities had characteristic differences between the studied fibroblast, liver and brain samples.

  9. The coiled-coil structure of LIMP-2 (zeige SCARB2 Antikörper) is required for its interaction with beta-glucocerebrosidase (zeige GBA Antikörper).

  10. L-type calcium channel blockers have the ex vivo effects of increasing GCase (zeige GBA Antikörper) activity and protein in mouse fibroblasts

GBA2 Antigen-Profil

Protein Überblick

Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O- glucosides, however, the relevance of such activity is unclear in vivo.

Genbezeichner und Symbole assoziert mit GBA2

  • glucosidase beta 2 (Gba2) Antikörper
  • glucosylceramidase beta 2 (Gba2) Antikörper
  • F630034E04 Antikörper

Bezeichner auf Proteinebene für GBA2

NLGase , beta-glucocerebrosidase 2 , beta-glucosidase 2 , bile acid , glucosidase, beta (bile acid) 2 , glucosylceramidase 2 , non-lysosomal glucosylceramidase , bile acid beta-glucosidase

GENE ID SPEZIES
230101 Mus musculus
298399 Rattus norvegicus
Ausgewählte Anbieter für anti-GBA2 (GBA2) Antikörper
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